Defeating Dementia

What You Can Do to Prevent Alzheimer's and Other Forms of Dementia

Richard Furman

• Publisher: Revell
• Year: 2018
• Print ISBN: 9780800728045
• eBook ISBN: 9781493412570
• Topic: Medicine
• Subtopic: Neurology

Dementia. It's one of the most dreaded conditions we face as we age. Many people claim they would rather be diagnosed with cancer than dementia or Alzheimer's. What many don't realize is that dementia is not a forgone conclusion as we get older. Our own lifestyle choices and habits can have a significant impact--for good or ill--on our chances of developing the disease. And that means there's hope.Drawing from the latest medical research, Dr. Richard Furman helps readers understand dementia and Alzheimer's and shows them how to make three powerful lifestyle changes that can help decrease the probability of developing this disease. He explains how eating the right foods, exercising, and sustaining an ideal weight can dramatically reduce the likelihood of developing dementia in the first place, and even how it can slow the progression of the disease in someone who has already received a diagnosis.

Part 1: Understanding Dementia

1
What Is Dementia?

Dementia Defined

If you had mentioned “dementia” to Mrs. Dell, she would not have known exactly what you were talking about. She had heard of Alzheimer’s disease but didn’t realize that Alzheimer’s is a type of dementia.

Dementia is a condition in which the brain gradually loses its ability to think and remember clearly. It involves a decline in memory or other thinking skills—such as judgment, orientation, comprehension, and language—that affects a person’s ability to carry out everyday activities. Whenever nerve cells in the brain are significantly damaged, the result is eventually dementia.

Dementia begins with damage to a number of nerve cells followed by initial symptoms beginning to show. As more nerve cells are damaged and eventually die, more symptoms occur, and the individual starts having more difficulty with memory and the ability to think clearly. Their behavior also begins to change. No one notices these symptoms at first, but as more brain cells die, the symptoms become more noticeable. Eventually, one’s ability to carry out daily activities becomes so impaired that someone else has to assist them in their everyday routines. This is the point at which a person is given the diagnosis of dementia. Perhaps the person first loses the ability to drive to the store. Then they are unable to perform basic functions such as dressing themselves or walking or eating without assistance. Eventually, they become bedridden and require care around the clock. Dementia is fatal, but the sad part of dementia is that life is gone long before death arrives. An article published in the medical journal Annals of Internal Medicine explains the definition of dementia best. Dementia is characterized by a change in memory, plus judgment, orientation, comprehension, or language, that is severe enough to interfere with daily life. We will cover the three stages of Alzheimer’s shortly and you will see that the term dementia corresponds with the beginning of the third stage of Alzheimer’s. When a person’s memory or reasoning or thought or understanding or awareness gets to the point of interfering with their daily life, from that point on, the process will be called Alzheimer’s dementia.

One other word you will see frequently mentioned in these medical reports is the word cognition. That word is used in the evaluation of mental testing of Alzheimer’s that relates to the participant’s memory, awareness of what is going on around them, comprehension and understanding of instructions, or their reasoning in making good decisions. The tests that are given to evaluate whether the Alzheimer’s is progressing or not is a measure of cognition. As your cognition worsens, so does the degree of Alzheimer’s progress.

Alzheimer’s Dementia

I have had people ask if a particular person had Alzheimer’s or dementia. One individual told me that both his grandfather and father lost their memory and ended up bedridden and dependent on others. He said his grandfather had dementia and his father had Alzheimer’s. They were different diseases in his thinking. If you say someone has Alzheimer’s, most people have a picture in mind of what is going on with that individual. They have known people with Alzheimer’s, have seen such people in movies, or have read books about such people. But if you were to tell the same people that someone has dementia, the picture that comes to mind is not nearly as clear. Most people are not sure what dementia is, and many think dementia and Alzheimer’s are different disease processes. The fact is that Alzheimer’s is a form of dementia. We will cover the three stages of Alzheimer’s later, and you will see that dementia corresponds with the third stage of Alzheimer’s.

Alzheimer’s dementia is the most common form of dementia. Alzheimer’s dementia is a complex entity. From a medical standpoint, we do not yet know what the initial step in the process is or what exactly causes Alzheimer’s dementia to get worse. We do know there are two basic markers within the brains of Alzheimer’s patients. These two protein products are called beta-amyloid and tau. In earlier years, to make the diagnosis, one had to perform an autopsy on someone with dementia symptoms in order to see the beta-amyloid plaques and the tau tangles imbedded in certain parts of the brain. In more recent years, brain-imaging devices have been developed that can detect the buildup of these products while a person is still alive. This process has been found to begin more than twenty years prior to any symptoms.

We also know there is more to Alzheimer’s than genes. A report in the medical journal Experimental Gerontology stated that Alzheimer’s is a chronic degeneration process in which less than 5 percent of all cases are solely due to genetics. If you had asked Mrs. Dell, she would have said Alzheimer’s is caused by a person’s genes. She would have been partially right, because a gene that is passed on in families can affect a person early on, usually between the ages of thirty and sixty. This type of Alzheimer’s is called familial Alzheimer’s disease. Very few people who develop Alzheimer’s have this early-onset type. It accounts for less than 5 percent of overall cases.

What is more common is called sporadic Alzheimer’s disease, and this usually occurs later in life, after the age of sixty. A gene called APOe4 makes a person more vulnerable to this type of Alzheimer’s disease. About 20 percent of Americans have this gene, but not everyone with it will end up with Alzheimer’s, and some people without the gene develop Alzheimer’s. The gene doesn’t cause the disease, but it can increase the risk.

The bottom line is this: you can’t change your inheritance, but you can make lifestyle changes to lower your risk of developing such a dreaded disease.

It wasn’t well known back in the day when Mrs. Dell was living a “normal” life, but now the Alzheimer’s Association says that about half of all people over the age of eighty-five have Alzheimer’s. If Mrs. Dell had known, perhaps she would have taken steps at a younger age to help prevent it or at least postpone the symptoms. She did not realize there were things she could do to slow or stop the progression even after she began showing symptoms.

Mrs. Dell had no idea what was happening between and within the cells of her brain. It would be twenty years before the initial symptoms would show themselves. Her life looked completely normal. She was happily married, had one married daughter, and embraced life to the fullest. Her days were fairly routine. She awoke early, fixed her husband’s breakfast, then turned to her favorite hobby, the colorful, blooming flower garden completely covering the front yard.

Every afternoon Mrs. Dell drove to the grocery store to pick up what she needed for dinner. It was a small store, and she knew the owners by name. She charged everything each day and paid her invoice once a month. The one item she replenished on a daily basis was ice cream. Strawberry was her favorite. On Saturdays she would buy extra for the weekend because the store was closed on Sundays.

Every night for dessert she had her pint of ice cream. But that wasn’t her only addiction. Mr. Dell brought home boxes of ice cream bars. There were six in a box, and her habit was one mid-morning and another in the middle of the afternoon.

Other than ice cream, she ate fairly normally for someone living in the South. She didn’t like fish but would eat anything else—beef, pork, a lot of hamburgers, anything fried, even fried green tomatoes.

Her blood pressure was “a little high,” as she liked to say with a laugh. But to her, “a little high” rather than “really high” meant that if she missed taking her blood pressure medicine now and then, it didn’t make that much difference.

Mrs. Dell had no clue what beta-amyloid was nor that it was beginning to build up in her brain. Neither did she realize that Alzheimer’s disease was one of the most dreaded diseases there is. That was not something anyone talked much about back then, even though Mrs. Dell’s mother had died with Alzheimer’s. She didn’t know about certain genes that would make her more vulnerable to Alzheimer’s, nor did she have any idea that certain genes would cause the disease early in life rather than late. All she knew was that her mother had developed it in her later years, and she was thankful that she had no such symptoms at her age. Mrs. Dell believed there was nothing that could be done to prevent Alzheimer’s, delay its onset, or slow its progression. She accepted it as just a part of aging.

Vascular Dementia

The second most common form of dementia is caused by disease in the arteries leading to the brain and within the brain. This is called vascular dementia. The symptoms of Alzheimer’s dementia and vascular dementia are practically indistinguishable, but pathological findings within the brain tissues reveal which type of problem is causing the symptoms of dementia.

If you were to do autopsy studies on the brains of people who have such symptoms, you would find certain specific abnormalities in the brain. If you were to look under a microscope at a thin slice of a particular area of the brain of someone who had the symptoms of forgetfulness or problems with their thinking process, you may see some unusual-looking protein plaques surrounding an area of brain cells that had died. If you looked closer inside those cells and saw a special type of protein called tau and saw these strands of tau protein were all tangled up, you would have the combination of findings for the diagnosis of Alzheimer’s dementia.

As we already discussed, the brains of people with Alzheimer’s dementia contain beta-amyloid plaques and tau tangles. The brains of those with vascular dementia contain very few of these plaques or tangles but do contain medium-sized or smaller arteries that became diseased and closed off from an inflammatory response with bleeding or became plugged due to plaque buildup within their walls. The autopsies of such brains would reveal large areas of brain damage as a result of a stroke. In such cases, the patients most likely experienced a stroke that was obvious to themselves and everyone else. It may have affected speech or some type of motor movement. This may have been followed sooner or later by the dementia symptoms we have been discussing. This form of vascular dementia is a result of disease of the larger arteries to the brain.

There is another form of vascular dementia that is different from the kind that reveals large strokes at autopsy. In this second form, autopsies of brain tissue reveal blockages in extremely small micro-arteries, and only a very small area of brain tissue is affected. Such areas are also the result of a stroke, but the blockage was so small and the area of brain tissue affected so petite that no symptoms of a stroke occurred. The patient didn’t even know they had a light stroke. Such a stroke is called a silent stroke, and a multitude of such events can lead to vascular dementia.

This type of stroke was highlighted in an eye-opening study done by the National Alzheimer’s Coordinating Center and published in the medical journal Neurology. In an autopsy study of brains, researchers found that 79.6 percent of individuals showing evidence of a stroke upon examination of the brain did not have a history of a stroke during their lifetimes. They did not have any symptoms.

If a small stroke is a little bit larger, the patient may witness a tinge of a problem that lasts only a short time, and then they completely recover. Such a stroke is called a transient ischemic attack or TIA. The symptoms are very transient, or brief, and then they disappear and the person is back to normal.

If I were back in medical school taking notes on a lecture on vascular dementia, I would write a short summary statement like this: a significant part of preventing dementia is the health of my arteries—from my largest artery to my smallest.

The Connection between Alzheimer’s Dementia, Vascular Dementia, and Mixed Dementia

If you were to go to your doctor with memory problems or with difficulty making decisions or because you weren’t able to figure out how to do something you used to do well, they would not be able to tell you definitively whether you had Alzheimer’s or problems in your brain caused by disease of the arteries. If you presented with memory symptoms, would the cause be solely beta-amyloid plaques, solely problems with the arteries, or a combination of the two?

The answer to that question is that the majority of Alzheimer’s cases have a mixed cause. Examinations of brain structure reveal a mixture of the Alzheimer’s beta-amyloid plaques and problems with the arteries of the brain.

An article published in Biomechanical Pharmacology concerned Alzheimer’s dementia and vascular dementia. The report stated that Alzheimer’s is a mixed disease and that the idea that these entities are completely separate has vanished.

You might think it would be simple to figure out if dementia were caused either by those beta-amyloid plaques and tau tangles that make the diagnosis of Alzheimer’s dementia or by the disease of the arteries that make the diagnosis of vascular dementia. But it is not that simple.

An article in the medical journal Lancet reported that the majority of dementia in the aging population is a mixture of plaques and tangles with arterial involvement. Researchers pointed out that if they examined the brains of individuals over the age of eighty who had been diagnosed with Alzheimer’s, they would likely not find only plaques or only blocked arteries as the sole cause. This combination of beta-amyloid plaques and arterial disease is called mixed dementia. A Statement for Healthcare Professionals from the American Heart Association/American Stroke Association states that a mixed cause, including the arterial component and the Alzheimer’s component, is the most common explanation for cognitive impairment in aging. This study showed that the effects of arterial disease on the brain were found in 84 percent of Alzheimer’s patients.

Another statement from the medical literature concerning the intertwining of Alzheimer’s dementia and vascular dementia is found in the medical journal Archives of Neurology. It stated, “Although Alzheimer’s dementia and vascular dementia have traditionally been viewed as distinct disorders, it is now generally agreed that the two rarely occur in isolation.” The article pointed out that what is a risk factor for one is a risk factor for the other. With there being no medication that can prevent or cure Alzheimer’s, modifying your lifestyle to alleviate the risk factors remains the cornerstone for the prevention of Alzheimer’s.

Several studies have found that in patients with a combination of Alzheimer’s disease and arterial disease, fewer of the hallmark beta-amyloid plaques are necessary to cause dementia symptoms if there is associated arterial disease. A key reminder is that the greater the decrease in the flow of blood in the brain, the greater the decline in cognitive function. We know steps that can be taken to prevent the arterial part of the problem. The health of your arteries is a key playe...

Table of contents

• Cover
• Title Page
• Copyright Page
• Dedication
• Epigraph
• Contents
• Foreword by Senator Bill Frist
• Foreword by Franklin Graham
• Introduction
• Part 1: Understanding Dementia
• Part 2: The Aging Process and the Health of Your Arteries
• Part 3: The Risk Factors for Developing Alzheimer’s
• Part 4: Lifestyle Choices for Defeating Dementia
• The Last Leaf
• Epilogue
• Conclusion
• References
• About the Author
• Back Ads
• Back Cover