Sudden Unexpected Death in Epilepsy

Mechanisms and New Methods for Analyzing Risks

Claire M. Lathers, Paul L. Schraeder, Jan E. Leestma, Braxton B. Wannamaker, Richard L. Verrier, F.A.C.C., Ph.D., Steven C. Schachter, MD, Claire M. Lathers, Paul L. Schraeder, Jan E. Leestma, Braxton B. Wannamaker, Richard L. Verrier F.A.C.C. Ph.D., Steven C. Schachter MD, Claire M. Lathers, Paul L. Schraeder, Jan E. Leestma, Braxton B. Wannamaker, Richard L. Verrier F.A.C.C. Ph.D., Steven C. Schachter MD

• Publisher: CRC Press
• Year: 2015
• Print ISBN:
  9781482223859
• Edition: 1
• eBook ISBN:
  9781482223880
• Topic: Law
• Subtopic: Forensic Science
• Index: Law

Sudden Unexpected Death in Epilepsy: Mechanisms and New Methods for Analyzing Risks builds on earlier works focusing on the clinical problem of sudden unexpected death in epilepsy (SUDEP). This book presents a methodology for identifying and classifying clusters of risks that lead to SUDEP. Developed over the last two years, the SUDEP Classificatio

Table of contents

• Front Cover
• Contents
• Foreword by Michael W. Bungo
• Foreword by Steven A. Koehler
• Foreword by Steven C. Schachter
• Preface
• Acknowledgments
• Editors
• Contributors
• Chapter 1: Mechanistic Mystery : Risk Factors in SUDEP
• Chapter 2: SUDEP : A Syndrome with Several If Not Many Potential Underlying Mechanisms
• Chapter 3: Unraveling the Global Mystery of SUDEP
• Chapter 4: Decision Analysis and Classification Methods for SUDEP Risk Factor Identification
• Chapter 5: Forensic SUDEP Cluster Risk Factor Identifier Method
• Chapter 6: Forensic Cases Classified as SUDEP Cluster Risk Factor Identifiers
• Chapter 7: How to and How Not to Use Cluster ID Method
• Chapter 8: Clinical Cases Classified as SUDEP Cluster Risk Factor Identifiers
• Chapter 9: SUDEP : Continued Forensic Challenges
• Chapter 10: A South Carolina Cohort of Epilepsy Patients
• Chapter 11: Measuring the Incidence of SUDEP Using Forensic and National Data
• Chapter 12: Risk Predictor : Individual SUDEP Risk Factor Cluster IDs
• Chapter 13: Intracranial Pressure, Cerebral Edema, and Obstructive Sleep Apnea : A Risk Factor Cluster for SUDEP?
• Chapter 14: Neurocardiac Interactions in Sudden Unexpected Death in Epilepsy : Can Ambulatory Electrocardiogram-Based Assessment of Autonomic Function and T-Wave Alternans Help to Evaluate Risk?
• Chapter 15: Patient Management Using Cluster Risk Factor Identifiers
• Chapter 16: Future Clinical and Animal Studies
• Chapter 17: Animal Model Cluster IDs : Mechanisms and Risk Factors for SUDEP
• Chapter 18: Sudden Death Animal Models to Study Nervous System Sites of Action for Disease and Pharmacological Intervention
• Chapter 19: A Characterization of the Lockstep Phenomenon in Phenobarbital-Pretreated Cats
• Chapter 20: Relationship of the Lockstep Phenomenon and Precipitous Changes in Blood Pressure
• Chapter 21: Interspike Interval Histogram Characterization of Synchronized Cardiac Sympathetic Neural Discharge and Epileptogenic Activity in the Electrocorticogram of the Cat
• Chapter 22: Abnormal Brain Activity Triggers Long-Term Potentiation in Sympathetic Ganglia : Implication for Sudden Death
• Chapter 23: β 1-Adrenergic Blockade Prevents Cardiac Dysfunction and Increased Susceptibility to Experimental Arrhythmias Following Status Epilepticus in Rats
• Chapter 24: Cardiac Myocyte Damage, Electrocardiographic Dysfunction, and Ion Channel Remodeling in Rodent Models of Seizure Disorders
• Chapter 25: A Rat Model for Exploring the Contributions of Ventricular Arrhythmias to Sudden Death in Epilepsy
• Chapter 26: Neurotransmitters Implicated in Control of Sudden Unexpected Death in Epilepsy in Animal Models
• Chapter 27: Omega-3 Fatty Acids and Sudden Unexpected Death in Epilepsy : A Translational Approach
• Chapter 28: Sudden Death in Epilepsy : Relationship to the Sleep–Wake Circadian Cycle and Fractal Physiology
• Chapter 29: Lockstep in Humans : Bridging the Gap
• Chapter 30: Postictal Generalized EEG Suppression and Sudden Unexpected Death in Epilepsy
• Chapter 31: Mechanisms of SUDEP : Lessons from Cases Occurring in the Epilepsy Monitoring Unit
• Chapter 32: Compliance with Antiepileptic Drug Treatment and the Risk of SUDEP
• Chapter 33: Providing Information about SUDEP : The Benefits and Challenges
• Chapter 34: Mechanistic SUDEP Risk Factor Studies for Animals and Humans
• Back Cover