Critical in the elimination of drugs and other xenobiotics from the body, cytochrome P450 has strong bearing on scientific assessments of genetic polymorphism in metabolism, possible drug-drug interactions, and bioavailability of candidate drugs. This text systematizes findings on P450 and similar enzymes--as well as parallel issues shaping the pharmaceutical industry--to promote the next generation of safer, more effective drugs. Topics include dioxygen activation, the identification and characterization of metabolites, bioactivation, P450 in lab animal species, enzyme kinetics, reaction phenotyping, drug-drug interactions, pharmacogenetics, hepatic clearance, and the role of UGTs.
eBook - PDF
Drug Metabolizing Enzymes
Cytochrome P450 and Other Enzymes in Drug Discovery and Development
- 609 pages
- English
- PDF
- Available on iOS & Android
eBook - PDF
Drug Metabolizing Enzymes
Cytochrome P450 and Other Enzymes in Drug Discovery and Development
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Information
Topic
MedizinSubtopic
PharmakologieTable of contents
- Front Cover
- Contents
- Editor's Preface
- Foreword
- 1. Dioxygen Activation by Cytochromes P450: A Role for Multiple Oxidants in the Oxidation of Substrates
- 2. Application of LC/MS, LC/NMR, NMR and Stable Isotopes in Identifying and Characterizing Metabolites
- 3. Bioactivation
- 4. Chemically Reactive Metabolites in Drug Discovery and Development
- 5. Cytochrome P450 and its Place in Drug Discovery and Development
- 6. Cytochrome P450 in Laboratory Animal Species
- 7. Typical and Atypical Enzyme Kinetics
- 8. Cytochrome P450 Reaction Phenotyping
- 9. Drug-Drug Interactions and the Cytochromes P450
- 10. CYP Gene Induction by Xenobiotics and Drugs
- 11. Cytochrome P450 Pharmacogenetics
- 12. Role of Intestinal Cytochromes P450 in Drug Disposition
- 13. Prediction of Hepatic Clearance in Humans from Experimental Animals and In Vitro Data
- 14. Non-P450 Mediated Oxidative Metabolism of Xenobiotics
- 15. The Role of Sulfotransferases (SULTs) and UDP-GlucuronosyItransferases (UGTs) in Human Drug Clearance and Bioactivation
- Index
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Yes, you can access Drug Metabolizing Enzymes by Jae Lee, R. Scott Obach, Michael B. Fisher, Jae Lee,R. Scott Obach,Michael B. Fisher in PDF and/or ePUB format, as well as other popular books in Medizin & Pharmakologie. We have over 1.5 million books available in our catalogue for you to explore.