Drug Repurposing in Cancer Therapy

Approaches and Applications

Kenneth K.W. To, William C.S. Cho

• Publisher: Academic Press
• Year: 2020
• Print ISBN:
  9780128196687
• eBook ISBN:
  9780128199039
• Topic: Biological Sciences
• Subtopic: Biology
• Index: Biological Sciences

Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. - Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research - Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences - Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types

Table of contents

• Cover
• Front Matter
• Table of Contents
• Copyright
• Contributors
• List of Illustrations
• List of Tables
• Chapter 1 : Drug repurposing for cancer therapy—an introduction
• Chapter 2 : A ligand-centric approach to identify potential drugs for repurposing: case study with aurora kinase inhibitors
• Chapter 3 : Machine learning strategies for identifying repurposed drugs for cancer therapy
• Chapter 4 : Unveiling potential anticancer drugs through in silico drug repurposing approaches
• Chapter 5 : Increasing opportunities of drug repurposing for treating breast cancer by the integration of molecular, histological, and systemic approaches
• Chapter 6 : The success story of drug repurposing in breast cancer
• Chapter 7 : A personalized medicine approach to drug repurposing for the treatment of breast cancer molecular subtypes
• Chapter 8 : Successful stories of drug repurposing for cancer therapy in hepatocellular carcinoma
• Chapter 9 : Stories of drug repurposing for pancreatic cancer treatment—Past, present, and future
• Chapter 10 : Animal models and in vivo investigations for drug repurposing in lung cancer
• Chapter 11 : Identification of chemosensitizers by drug repurposing to enhance the efficacy of cancer therapy
• Chapter 12 : Drugs repurposed to potentiate immunotherapy for cancer treatment
• Chapter 13 : Nanoparticle-based formulation for drug repurposing in cancer treatment
• Chapter 14 : Nanotechnological approaches in cancer: the role of celecoxib and disulfiram
• Chapter 15 : Clinical trials on combination of repurposed drugs and anticancer therapies
• Index
• A