Bone Cancer

Progression and Therapeutic Approaches

Dominique Heymann

• Publisher: Academic Press
• Year: 2009
• Print ISBN: 9780123748959
• eBook ISBN: 9780080953885
• Topic: Medicine
• Subtopic: Endocrinology & Metabolism

The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches.Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on a patient's quality of life and are a main cause of patient mortality. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for the medical and cancer research communities. This book provides, all in one resource, the most recent data on bone cancer development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Feature- Presents a comprehensive, translational source for all aspects of bone cancer in one reference work- Bone cancer experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches.- Clear presentation by bone biologists of the cellular and molecular mechanisms underlying bone tumors and bone cancer metastasis as well as the genomic and proteomic assays used in detecting cancer within given organ systems-- Clear presentation by oncologists and radiologists of how histopathology, imaging, and pain monitoring can lead to new therapeutic approaches Benefit- Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone cancer issues, as opposed to searching through thousands of journal articles.- Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system- Correct diagnosis (and therefore correct treatment) of cancer depends on a strong understanding of the molecular basis for the disease – both oncologists and radiologists will benefit- Bone biologists will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays

Table of contents

• Cover image
• Table of Contents
• Copyright
• Foreword
• Preface
• List of Contributors
• Chapter 1. Epidemiology of Primary Bone Tumors and Economical Aspects of Bone Metastases
• Chapter 2. Tumor-Bone Cell Interactions in Bone Metastases
• Grant Support
• I. Introduction
• II. Mechanisms of Osteolytic Metastases from Solid Tumors
• III. Skeletal Complications of Multiple Myeloma
• IV. Osteoblastic Bone Metastases
• Chapter 3. Early Bone Metastasis-Associated Molecular and Cellular Events
• Chapter 4. Regulation of Osteoblast Differentiation and Bone Cancers by Wnt and PTH Signaling Pathways
• Chapter 5. Osteoclast Differentiation and Function
• Chapter 6. Immunoregulation of Osteoclast Differentiation in Multiple Myeloma Bone Disease
• Chapter 7. Facts and Hypothesis on Osteolytic Lesions Related to Normal and Tumoral Epithelial Dental Cell Differentiation
• Chapter 8. The Role of the Interleukin-6 Family of Cytokines in Bone Remodeling and Bone Cancer
• Chapter 9. Proteases and Therapeutic Approaches of Bone Tumors
• Chapter 10. Bone Remodeling Markers and Bone Cancer
• Chapter 11. Cytogenetic and Molecular Genetic Alterations in Bone Tumors
• Chapter 12. Cytogenetics of Bone Tumors
• Chapter 13. Genetic Aspects of Bone Tumors
• Chapter 14. Proteomics of Bone Cancer
• Chapter 15. Genomic and Proteomic Profiling of Osteosarcoma
• Chapter 16. Molecular Pathology of Osteosarcoma
• Chapter 17. Technical Aspects
• Chapter 18. Osteoclast-rich Lesions of Bone
• Chapter 19. Recent Advances in the Biology of Bone Tumors and New Diagnostic Tools
• Chapter 20. Ewing’s Sarcoma Family of Tumors
• Chapter 21. The Histopathology of Skeletal Metastases
• Chapter 22. Interventional Radiologic Techniques and their Contribution to the Management of Bone Tumors
• Chapter 23. Imaging of Bone Metastases
• Chapter 24. Diagnosis of Skeletal Metastases in Malignant Extraskeletal Cancers
• Chapter 25. Pain Control with Palliative Radiotherapy in Bone Metastases
• Chapter 26. Mechanisms and Management of Bone Cancer Pain
• Chapter 27. Malignant Skeletal Pain
• Chapter 28. Animal Models of Malignant Primary Bone Tumors and Novel Therapeutic Approaches
• Chapter 29. In vivo Models Used in Studies of Bone Metastases
• Chapter 30. Cytokine Gene Therapy in Bone Remodeling
• Chapter 31. Non-surgical Treatment of Chondrosarcoma
• Chapter 32. Mechanistic Role of RANKL in Cancer-induced Bone Diseases and Development of a Targeted Therapy to Inhibit this Pathway
• Chapter 33. Chondrosarcoma of Bone
• Chapter 34. Current Status of Immunotherapy for Osteosarcoma and its Future Trends
• Chapter 35. Bisphosphonates, Bone Health and the Clinical Biology of Bone Metastases from Breast Cancer
• Chapter 36. A Multi-targeted Approach to Treating Bone Metastases
• Chapter 37. Bone Metastases of Prostatic Cancer
• Chapter 38. Apoptosis and Drug Resistance in Malignant Bone Tumors
• Index