Gene Environment Interactions

Nature and Nurture in the Twenty-first Century

Moyra Smith

• Publisher: Academic Press
• Year: 2020
• Print ISBN:
  9780128196137
• eBook ISBN:
  9780128197974
• Topic: Medizin
• Subtopic: Genetik in der Medizin

Gene Environment Interactions: Nature and Nurture in the Twenty-first Century offers a rare, synergistic view of ongoing revelations in gene environment interaction studies, drawing together key themes from epigenetics, microbiomics, disease etiology, and toxicology to illuminate pathways for clinical translation and the paradigm shift towards precision medicine. Across eleven chapters, Dr. Smith discusses interactions with the environment, human adaptations to environmental stimuli, pathogen encounters across the centuries, epigenetic modulation of gene expression, transgenerational inheritance, the microbiome's intrinsic effects on human health, and the gene-environment etiology of cardiovascular, metabolic, psychiatric, behavioral and monogenic disorders. Later chapters illuminate how our new understanding of gene environment interactions are driving advances in precision medicine and novel treatments. In addition, the book's author shares strategies to support clinical translation of these scientific findings to improve heath literacy among the general population. - Offers a thorough, interdisciplinary discussion on recent revelations from gene environment interaction studies - Illuminates environmental factors affecting disease-gene etiology and treatment - Supports the clinical translation of gene environment interaction findings into novel therapeutics and precision medicine

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• Acknowledgments
• Epigraph
• 1: Interacting with the environment receiving and interpreting signals
• 2: Environment as provider
• 3: Evolution
• 4: Gene and environment interactions and phenotypes
• 5: Signals, epigenetics, regulation of gene expression
• 6: Maintaining homeostasis and mitigating effects of harmful factors in the intrinsic or extrinsic environment
• 7: Microorganisms and microbiome
• 8: Genomic changes and environmental factors in causation of birth defects and neurodevelopmental disorders
• 9A: Personalized precision medicine—Part A: Concepts and relevance in Mendelian disorders
• 9B: Personalized medicine. Precision medicine: PART B multifactorial diseases, genes, environments, interactions
• 10: Integrating genetic, epigenetic and environmental information to improve health and well-being
• 11: Environments, resources, and health
• 12: Summary chapter epilogue
• Index