Strategies and Tactics in Organic Synthesis

Michael Harmata

• Publisher: Academic Press
• Year: 2014
• Print ISBN: 9780124171855
• eBook ISBN: 9780124171916
• Topic: Physical Sciences
• Subtopic: Organic Chemistry

A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, we are given stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. This book series shows how synthesis is really done, and we are educated, challenged and inspired by these accounts, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world.- Presents state-of-the-art developments in organic synthesis- Provides insight and offers new perspective to problem-solving- Written by leading experts in the field

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• Dedication
• Contributors
• Preface
• Chapter 1: Substrate-Directed Heck–Matsuda Arylations: From Curiosity to a Valuable Synthetic Tool
• Chapter 2: (−)-Berkelic Acid: Lessons Learned From Our Investigations on a Scalable Total Synthesis
• Chapter 3: The Mysterious Case of the Kingianins
• Chapter 4: Total Synthesis of Chinensiolide B: An Exercise in Functional Group Selectivity with the Help of a Fortuitous Side Product and a Good Nose
• Chapter 5: Syntheses of the Bisindole Alkaloids of the Genera Borreria and Flindersia
• Chapter 6: Synthesis of (±)-Amathaspiramide F: Stereochemical Switch of a [2,3]-Stevens Rearrangement
• Chapter 7: Oxabicyclic Building Blocks as Key Intermediates in the Synthesis of the Natural Products (−)-Platensimycin and (+)-Frondosin A
• Chapter 8: Structure Inspires a New Method That Delivers the Synthesis of Natural Products and Analogs in the Pederin Family
• Chapter 9: Gliocladin C: The Development and Application of a Pyrroloindoline–Indole Radical Coupling Reaction
• Chapter 10: Studies in the Synthesis of Biaryl Natural Products: The 6,6′-Binaphthopyranones
• Chapter 11: Sleepless Nights: The Total Synthesis of the Anticancer Australian Rainforest Polyketide EBC-23
• Chapter 12: Total Synthesis of the Crinipellins
• Index