DNA Repair in Cancer Therapy

Molecular Targets and Clinical Applications

Mark R. Kelley, Melissa L. Fishel

• Publisher: Academic Press
• Year: 2016
• Edition: 2
• eBook ISBN:
  9780128035993
• Topic: Scienze biologiche
• Subtopic: Oncologia

DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs. Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors. - Provides a comprehensive overview of the basic and translational research in DNA repair as a cancer therapeutic target - Includes timely updates from the earlier edition, including Fanconi Anemia cross-link repair, translesion DNA polymerases, chemotherapy induced peripheral neuropathy, and many other new areas within DNA repair and cancer therapy - Saves academic, medical, and pharma researchers time by allowing them to quickly access the very latest details on DNA repair and cancer therapy - Assists researchers and research clinicians in understanding the importance of the breakthroughs that are contributing to advances in disease-specific research

Table of contents

• Cover
• Front matter
• Table of Contents
• Copyright
• List of Contributors
• Preface
• Acknowledgments
• List of Illustrations
• List of Tables
• Chapter 1 : Overview of DNA repair pathways, current targets, and clinical trials bench to clinic
• Chapter 2 : MGMT—a critical DNA repair gene target for chemotherapy resistance
• Chapter 3 : Understanding the basics for translating the base excision repair pathway from benchtop to bedside in cancer treatment
• Chapter 4 : The role of PARP in DNA repair and its therapeutic exploitation
• Chapter 5 : Targeting the nucleotide excision repair pathway for therapeutic applications
• Chapter 6 : The DNA mismatch repair pathway
• Chapter 7 : Chemotherapeutic intervention by inhibiting DNA polymerases
• Chapter 8 : Targeting homologous recombination repair in cancer
• Chapter 9 : DNA double-strand repair by nonhomologous end joining and its clinical relevance
• Chapter 10 : Diversity and implication of MAPK signal transduction involved in the regulation of chemotherapy-induced DNA damage response
• Chapter 11 : Radiation DNA damage and use in cancer/therapeutics-translation of radiation modifiers
• Chapter 12 : The FANCA to FANCZ of DNA interstrand crosslink repair: Lessons from Fanconi anemia
• Chapter 13 : The role of DNA damage and repair in toxicity to postmitotic cells caused by cancer therapies
• Subject Index
• Page 429 Page 432 A