A Historical Perspective on Evidence-Based Immunology
eBook - ePub

A Historical Perspective on Evidence-Based Immunology

  1. 394 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

A Historical Perspective on Evidence-Based Immunology

About this book

A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells. - Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles - Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology - Presents concepts such as the division of lymphocytes into functionally different populations in their historical context - Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells

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Yes, you can access A Historical Perspective on Evidence-Based Immunology by Edward J. Moticka in PDF and/or ePUB format, as well as other popular books in Medicine & Immunology. We have over one million books available in our catalogue for you to explore.

Information

Publisher
Elsevier
Year
2015
Print ISBN
9780123983817
eBook ISBN
9780123983756
Topic
Medicine
Subtopic
Immunology

Table of contents

  1. Cover image
  2. Title page
  3. Table of Contents
  4. Dedication
  5. Copyright
  6. Foreword
  7. Glossary of Historical Terms
  8. Chapter 1. Innate Host Defense Mechanisms and Adaptive Immune Responses
  9. Chapter 2. Hallmarks of the Adaptive Immune Responses
  10. Chapter 3. Two Effector Mechanisms of the Adaptive Immune Response
  11. Chapter 4. The Small Lymphocyte Is the Antigen Reactive Cell
  12. Chapter 5. Lymphocytes Transform into Plasma Cells and Produce Antibodies
  13. Chapter 6. The Clonal Selection Theory of Antibody Formation
  14. Chapter 7. Plasma Cells Produce Antibody of a Single Specificity
  15. Chapter 8. Self–Non-self Discrimination: How the Immune System Avoids Self-Destruction
  16. Chapter 9. The Thymus in Lymphocyte Maturation
  17. Chapter 10. The Bursa of Fabricius in Lymphocyte Maturation
  18. Chapter 11. Revealing the Structure of the Immunoglobulin Molecule
  19. Chapter 12. Complement
  20. Chapter 13. Antibody Production Requires Thymus-Derived and Bone Marrow (Bursa)-Derived Lymphocyte Interactions
  21. Chapter 14. Cell Collaboration in the Antibody Response: Role of Adherent Cells
  22. Chapter 15. Recognition Structures on Cells of the Innate Host Defense Mechanisms
  23. Chapter 16. The Adaptive Immune Response and Histocompatibility Genes
  24. Chapter 17. Interaction of Lymphocytes with Antigen: Identification of Antigen-Specific Receptors
  25. Chapter 18. Generation of Diversity in the Adaptive Immune Response
  26. Chapter 19. B Lymphocyte Activation
  27. Chapter 20. Activation of T Lymphocytes and MHC Restriction
  28. Chapter 21. Development of Tolerance to Self in B Lymphocytes
  29. Chapter 22. Development of Tolerance to Self in T Lymphocytes
  30. Chapter 23. T Lymphocyte Subpopulations
  31. Chapter 24. T Lymphocyte Control of the Immune Response: From TS to TREG
  32. Chapter 25. Intercellular Communication in the Immune System
  33. Chapter 26. Antibody-Mediated Effector Mechanisms
  34. Chapter 27. T-Lymphocyte-Mediated Effector Mechanisms
  35. Chapter 28. Lymphocytes that Kill: Natural Killer (NK) and Natural Killer T (NKT) Lymphocytes
  36. Chapter 29. Role of Dendritic Cells in the Adaptive Immune Response
  37. Chapter 30. The Mucosal Immune System and Secretory IgA
  38. Chapter 31. Disorders of the Innate Host Defenses
  39. Chapter 32. Defects in the Adaptive Immune Response Leading to Recurrent Infections
  40. Chapter 33. Pathologies Resulting from Aberrant Immune Responses
  41. Chapter 34. Immune Responses Directed Against Self
  42. Chapter 35. Lymphoproliferative Diseases
  43. Chapter 36. Transplantation Immunology
  44. Chapter 37. Tumor Immunology
  45. Chapter 38. Therapies That Manipulate Host Defense Mechanisms
  46. Chapter 39. Techniques to Detect and Quantify Host Defenses
  47. Chapter 40. The Future of Immunology
  48. Index