- 457 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
eBook - ePub
The Immunoglobulin FactsBook
About this book
The FactsBook series has established itself as the best source of easily accessible and accurate facts about protein groups. Books in the series use an easy-to-follow format and are meticulously researched and compiled by experts in the field.The Immunoglobulin FactsBook is the first published reference for all 203 human functional and ORF immunoglobulin genes. It is complete and standardized and employs nomenclature approved by the HUGO Nomenclature Committee.
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Yes, you can access The Immunoglobulin FactsBook by Marie-Paule Lefranc,Gerard Lefranc in PDF and/or ePUB format, as well as other popular books in Medicine & Immunology. We have over one million books available in our catalogue for you to explore.
Information
Section II
The Human Immunoglobulin IGH Genes
Part 1 IGHC
Part 2 IGHD
Part 3 IGHJ
Part 4 IGHV
Part 1
IGHC
IGHA1
Nomenclature
IGHAl: Immunoglobulin heavy constant alpha 1.
Definition and functionality
IGHAl is one of the nine functional genes of the human IGHC group which comprises 11 mapped genes.
Gene location
IGHAl is in the IGH locus on chromosome 14 at 14q32.33.
Gene structure
The IGHAl gene comprises three exons, with the hinge region being encoded at the beginning of the second exon. This organization is similar to that of the IGHA2 gene but different from the IGHD and IGHG genes which have separate hinge exons.
Nucleotide and amino acid sequences for human IGHAl
The nucleotide between parentheses at the beginning of exons comes from a DONOR_SPLICE (n from ngt). The first nucleotide from an INT_DONOR_SPLICE is underlined (n from ngt).
The Cysteines involved in the CHI, CH2 and CH3 intrachain disulphide bridges are shown with their number and letter C in bold. The Cysteines involved in the H-L or H-H interchain disulphide bridges are shown with only the letter C in bold. References are shown in square brackets.
(s) Transcript of a secreted chain.
Genome database accession numbers
| GDB:119332 | LocusLink: 3493 | OMIM: 146900 |
IGHA2
Nomenclature
IGHA2: Immunoglobulin heavy constant alpha 2.
Definition and functionality
IGHA2 is one of the nine functional genes of the human IGHC group which comprises 11 mapped genes.
Gene location
IGHA2 is in the IGH locus on chromosome 14 at 14q32.33.
Gene structure
The IGHA2 gene comprises three exons, with the hinge region being encoded at the beginning of the second exon. This organization is similar to that of the IGHA2 gene but different from the IGHD and IGHG genes which have separate hinge exons.
Nucleotide and amino acid sequences for human IGHA2
The nucleotide between parentheses at the beginning of exons comes from a DONOR_SPLICE (n from ngt). The first nucleotide from an INT_DONOR_SPLICE is underlined (n from ngt).
The Cysteines involved in the CHI, CH2 and CH3 intrachain disulphide bridges are shown with their number and letter C in bold. The Cysteines involved in the H-L or H-H interchain disulphide bridges are shown with only the letter C in bold.
...
Table of contents
- Cover Image
- Other books in the FactsBook Series
- Table of Contents
- Title
- Preface
- Aide-Mmoire
- Copyright
- Section I The Introdructory chapters
- Section II The Human Immunoglobulin IGH Genes
- Section III The Human Immunoglobulin IGK Genes
- Section IV The Human Immunoglobulin IGL Genes
- Abbreviations
- IMGT standardized labels used in this book
- Index