
- 464 pages
- English
- PDF
- Available on iOS & Android
Antigenic Variation
About this book
The topic of antigenic variation is important in both biology and medicine. It is of enormous interest, as it describes the process(es) whereby microorganisms 'shift shape', by genetic rearrangement or otherwise. In medical terms, this has a major impact on the infectious disease process, since the immune system has great difficulty in keeping up with this variation, and thus eliminating the infectious agent. Antigenic variation is a major method by which microbes evade the immune response, and persist in the body.The broad scope of the book appeals to all those working in the field of infectious disease, immunology of infection, pathogenesis, molecular biology and also to evolutionary biologists. Topics covered include not only bacterial species, and viruses such as influenza, HIV, Rotavirus, but also eukaryotic parasites - one of the most fascinating groups of organisms exhibiting this behaviour.Comprehensive coverage of antigenic variation from viruses to parasitesDiscussions devoted to molecular mechanisms of host evasionDetailed descriptions of host/pathogen interactions
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Information
Table of contents
- Contents
- Contributors
- Foreword
- Preface
- 1 Mechanisms of Antigenic Variation: an Overview
- 2 HIV Variation - a Question of Signal-to-Noise
- 3 Calicivirus
- 4 Influenza - the Chameleon Virus
- 5 Rotavirus
- 6 Haemophilus i nfluenzae
- 7 Phase Variation in Helicobacter Pylori l ipopolysaccaride
- 9 Candida albicans
- 10 The MSG Gene Family and Antigenic Variation in the Fucus Pneumocystis carinii
- 11 Trypanosome Antigenic Variation - a Heavy Investment in the Evasion of Immunity
- 12 Antigenic Variation in Anaplasma marginale and Ehrlichia (Cowdria) ruminatium
- 13 Antigenic Variation and its Significance to Babesia
- 14 Antigenic Variation in Plasmodium falciparum and Other Plasmodium Species
- 15 Antigenic Variation in Borrelia: Relapsing Fever and Lyme Borreliosis
- 16 Surface Antigenic Variation in Giardia lamblia
- 17 Free-living and Parasitic Ciliates
- 18 The Impact of Antigenic Variation on Pathogen Population Structure, Fitness and Dynamics
- Index