Excitatory Amino Acids
eBook - PDF

Excitatory Amino Acids

Clinical Results with Antagonists

  1. 156 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Excitatory Amino Acids

Clinical Results with Antagonists

About this book

Glutamate is the major excitatory neurotransmitter in the brain and dysfunction of glutamate transmission is the likely cause of a variety of diseases including neurodegeneration following cerebral ischemia, Huntington's chorea, amyotrophic lateral sclerosis, epilepsy, spasticity, emesis, chronic pain, and schizophrenia. Excitatory amino acid receptor agonists and antagonists are therefore of major interest as potential drugs for central nervous system disorders. Excitatory Amino Acids is the first book entirely dedicated to the results of human testing of modulators of excitatory amino acid neurotransmitters. - Coverage of the field of excitatory amino acids from synaptic function to preclinical and clinical pharmacology - Description of the development of NMDA (Nmethyl-d-aspartate) and non-NMDA antagonists - Reports of potential drugs in early and late clinical stages of development

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Yes, you can access Excitatory Amino Acids by Paul L. Herrling in PDF and/or ePUB format, as well as other popular books in Medizin & Pharmakologie. We have over one million books available in our catalogue for you to explore.

Information

Publisher
Academic Press
Year
1997
Print ISBN
9780125468206
eBook ISBN
9780080531342
Topic
Medizin
Subtopic
Pharmakologie

Table of contents

  1. Front Cover
  2. Excitatory Amino Acids – Clinical Results with Antagonists
  3. Copyright Page
  4. Contents
  5. Contributors
  6. Preface
  7. Acknowledgments
  8. Chapter 1. Selfotel (CGS 19755)
  9. Chapter 2. D-CPPene (SDZ EAA-494)—A Competitive NMDA Antagonist: Pharmacology and Results in Humans
  10. Chapter 3. Intrathecal Administration of a Competitive NMDA Receptor Antagonist for Pain Treatment
  11. Chapter 4. Clinical Experience with the NMDA Ion Channel Blocker, Aptiganel Hydrochloride (CERESTAT®)
  12. Chapter 5. Development of ACPC, A Partial Agonist of the Glycine Site on the NMDA Receptor
  13. Chapter 6. Ifenprodil and Eliprodil: Neuroprotective NMDA Receptor Antagonists and Calcium Channel Blockers
  14. Chapter 7. (3S,4aR,6R,8aR)-6-[2-(1(2)H-Tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic Acid (LY293558) and its Racemate (LY215490): A Selective and Competitive AMPA/Kainate Receptor Antagonist
  15. Chapter 8. The NBQX Story
  16. Chapter 9. Riluzole in Amyotrophic Lateral Sclerosis
  17. Chapter 10. Preclinical and Clinical Aspects of Remacemide Hydrochloride
  18. Glossary
  19. Summary Table of Compounds and Their Clinical Status
  20. References
  21. Index