Principles of Tumors

A Translational Approach to Foundations

Leon P. Bignold

• Publisher: Academic Press
• Year: 2019
• Print ISBN:
  9780128169209
• Edition: 2
• eBook ISBN:
  9780128173299
• Topic: Biological Sciences
• Subtopic: Oncology
• Index: Biological Sciences

Principles of Tumors: A Translational Approach to Foundations, Second Edition, provides a concise summary of translational/interdisciplinary topics on the various aspects of tumors, especially abnormalities in their cells, their causes and effects on patients. Topics discussed include how genomic abnormalities in tumors may result from the actions of carcinogens and how genomic changes determine the cell biological/morphological abnormalities in tumor cell populations. In addition, the relationships between tumor cell genomics and therapeutic outcomes are described. There are also supporting appendices on general bioscience, including the principles of histology (the cells and tissues of the body), genetics, pathology, radiology and pharmacology. This book gives a thorough, detailed, yet concise account of the main bioscience, clinical and therapeutic aspects of tumors. It emphasizes the translational aspects of research into tumors with extensive discussions of interdisciplinary issues. The content in this book will be invaluable for researchers and clinicians involved in collaborative projects where it is necessary to understand fundamental issues in other branches of biomedicine. - Presents content that has been totally updated with the most recent developments of the field, including new chapters on tumor imaging exams, new surgical techniques, immunotherapy, gene therapy, and several novel therapies using natural and synthetic compounds - Presents translational approaches for every topic to improve conceptual insights for new research projects - Covers a broad range of subjects, making it easier for the reader to understand related fields - Includes diagrams for complex topics to aid in understanding for non-specialists

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• Preface to the second edition
• Chapter 1. Introduction
• Chapter 2. Theories and definitions of tumors
• Chapter 3. Etiopathogenesis of tumors
• Chapter 4. Growth of cells, growth factors, and oncogenes
• Chapter 5. Hereditary predispositions to tumors, tumor suppressor genes, and their clinico-genomic complexities
• Chapter 6. The tumor types: The complexities in the combinations and variabilities of their traits
• Chapter 7. Epidemiology of tumors
• Chapter 8. Prevention of tumors
• Chapter 9. Clinical features of tumors
• Chapter 10. Typing, grading, and staging of cases of tumor
• Chapter 11. Endoscopic visualization and imaging assessments of cases of tumor
• Chapter 12. Principles of surgery for tumors
• Chapter 13. Principles of nonsurgical therapies
• Chapter 14. Aspects of radiation therapy
• Chapter 15. Specific aspects of cytotoxic and hormonal drug therapies
• Chapter 16. Immunotherapies
• Chapter 17. Gene therapies not related to immunological therapies
• Chapter 18. Less common and controversial therapies
• Chapter 19. Care after primary therapy
• Chapter 20. Costs, ethics, and malpractice litigation
• Appendix 1. Principles of normal embryology, histology, and related cell biology
• Appendix 2. Aspects of the normal genome
• Appendix 3. Fixed genomic events and possible mechanisms of their causation by etiological agents
• Appendix 4. Genomic instabilities: kind, effects, and roles in the immortality of tumor cell populations
• Appendix 5. Methods in histologic and molecular assessments of tumors
• Appendix 6. “Biomarkers” in molecular pathology and oncology
• Appendix 7. Sublethal injuries and deaths of cells and tissues
• Appendix 8. “Pretarget,” “target,” and recovery capacity defenses of cells against carcinogens and cytotoxic agents
• Appendix 9. Developing and testing new therapies: clinical trials
• Index