Regulatory Proteolytic Enzymes and Their Inhibitors

11th Meeting Copenhagen 1977

Staffan Magnusson, Martin Ottesen, Bent Foltmann, Staffan Magnusson, Martin Ottesen, Bent Foltmann

• Publisher: Pergamon
• Year: 2014
• Print ISBN: 9780080226286
• eBook ISBN: 9781483153896
• Topic: Biological Sciences
• Subtopic: Biology
• Index: Biological Sciences

Regulatory Proteolytic Enzymes and Their Inhibitors consists of contributed papers from the 11th Meeting of the Federation of European Biochemical Societies in Copenhagen in 1977. This collection describes the role of proteases in the physiological regulation, a matter of the activation and de-activation of enzymes. The text also discusses the activation mechanism of pepsinogen and other acid protease zymogens. One paper reviews a discovery — that of a separate and distinct class of precursors, the pre-secretary proteins, and then discusses other studies on preproinsulin. The text then discusses the primary structures and presumed functions of immunoglobulin precursors. Another paper continues with the work of Reich and co-workers who found that transformation of cultured fibroblasts from different species by oncogenic viruses is related to the production and release of proteases that are responsible in activating the proenzyme plasminogen into plasmin. Another paper discusses plasminogen activation as having some relationship with pathological processes. The book also reviews the plasminogen activator secretion by normal and neoplastic human tissues. The text discusses the results when primary cultures established from biopsies of normal kidneys secreted plasminogen activators in amounts over those secreted by actual malignant tissues. The book then notes the role of neutral and acid proteinases in male reproduction and the role of plasminogen activators in female ovulation. This collection can be useful for micro-biologists, research biologists, molecular scientists, and students of molecular biology.

Table of contents

• Front Cover
• Regulatory Proteolytic Enzymes and Their Inhibitors
• Copyright Page
• Table of Contents
• GENERAL INTRODUCTION TO THE PROCEEDINGS
• Chapter 1. THE ROLE OF PROTEASES IN PHYSIOLOGICAL REGULATION: AN OVERVIEW
• Chapter 2. ACTIVATION, ACTION AND INHIBITION OF TRYPSIN AS DEDUCED FROM THE THREEDIMENSIONAL STRUCTURES OF TRYPSINOGEN, TRYPSIN AND THEIR COMPLEXES WITH THE BASIC PANCREATIC TRYPSIN INHIBITOR
• Chapter 3. THE ACTIVATION MECHANISM OF PEPSINOGEN AND OTHER ACID PROTEASE ZYMOGENS
• Chapter 4. CONFORMATION DEPENDENT FUNCTION OF CARBOXYPEPTIDASE A
• Chapter 5. BIOSYNTHESIS OF POLYPEPTIDE HORMONES IN INTACT AND CELL-FREE SYSTEMS
• Chapter 6. THE BIOSYNTHESIS OF MELITTIN: FROM THE PRIMARY PRODUCT OF TRANSLATION TO THE LYTIC PEPTIDE
• Chapter 7. ROLE OF PROTEASES IN THE SECRETION OF LYSOZYME, OVOMUCOID, CONALBUMIN AND OVALBUMIN FROM THE CHICK OVIDUCT
• Chapter 8. COMPLETE PRIMARY STRUCTURES AND PRESUMED FUNCTIONS OF IMMUNOGLOBULIN PRECURSORS
• Chapter 9. PROTEASES FROM CULTURED MALIGNANT CELLS
• Chapter 10. THE TISSUE ACTIVATOR OF PLASMINOGEN
• Chapter 11. EFFECTS OF THROMBIN, OTHER PROTEASES AND MALIGNANT TRANSFORMATION ON THE MAJOR CELL SURFACE-ASSOCIATED GLYCOPROTEIN, FIBRONECTIN
• Chapter 12. CELL SURFACE PROTEOLYSIS AND THE TRANSFORMED PHENOTYPE
• Chapter 13. PLASMINOGEN ACTIVATOR SECRETION BY NORMAL AND NEOPLASTIC HUMAN TISSUES CULTURED IN VITRO.
• Chapter 14. THE STRUCTURES OF FIBRINOGEN AND FIBRIN
• Chapter 15. SPERM PROTEINASES AND THEIR INHIBITORS
• Chapter 16. STUDIES ON THE ROLE OF PLASMINOGEN ACTIVATOR IN OVULATION AND EARLY EMBRYOGENESIS
• Chapter 17. GRANULOCYTE PROTEASES, THEIR RELEASE AND INHIBITION IN THE BODY
• Chapter 18. EVOLUTION OF AVIAN OVOMUCOIDS
• Chapter 19. STRUCTURE-FUNCTION RELATIONSHIPS OF SOYBEAN DOUBLE-HEADED PROTEINASE INHIBITORS
• Chapter 20. FUNCTION AND STRUCTURE OF HUMAN PLASMA a,-ANTITRYPSIN
• Chapter 21. LIBERATION OF KUNITZ-TYPE INHIBITORS FROM THE INTER-ALPHA-TRYPSIN-INHIBITOR BY LIMITED PROTEOLYSIS
• INDEX