Scientific and Engineering Principles

Proceedings of the Sixth International Fermentation Symposium Held in London, Canada, July 20-25, 1980

Murray Moo-Young, Campbell W. Robinson, Claude Vezina

• Publisher: Pergamon
• Year: 2013
• Print ISBN:
  9780080253831
• eBook ISBN:
  9781483148458
• Topic: Technology & Engineering
• Subtopic: Industrial & Technical Chemistry
• Index: Technology & Engineering

Advances in Biotechnology, Volume I: Scientific and Engineering Principles is the first of a series of three volumes and is based on the proceedings of the Sixth International Fermentation Symposium (IFS-6) held in London, Ontario, Canada, 20-25 July 1980. This volume is organized into 13 sections and contains 111 papers which represent about 80% of the total submitted. Section I contains papers on microbial cultures. Section II presents studies on recombinant DNA and microbial genetics. The papers in Section III deal with plant and animal cell and tissue culture. Section IV examines the microbial oxidation of hydrocarbons. Sections V and VI focus on continuous cultures and free-cell fermentation, respectively. Section VII examines process dynamics and control. Section VIII takes up computer applications in biotechnology, while Section IX covers process instrumentation and analytical methods. Section X contains papers on transport phenomena, mixing and scale-up. Section XI examines the design and operation of unconventional bioreactors. Sections XII covers fixed-, fluidized- and semi-fluidized bed bioreactors, while Section XIII presents studies on immobilization bioreactors. The volume also includes invited keynote addresses of Nobel Laureate, Professor Joshua Lederberg, and Professor Elmer L. Gaden, Jr. Abstracts of the round-table discussion on Technology Transfer and Economics, and on Biotechnology Training Programs are presented as appendices.

Table of contents

• Front Cover
• Scientific and Engineering Principles
• Copyright Page
• Table of Contents
• Editorial Board
• PREFACE
• GUEST EDITORIAL I. IBIOCHEMICAL ENGINEERING: WHERE HAS IT BEEN AND WHERE IS IT GOING?
• GUEST EDITORIAL II. GENETICS AND INDUSTRIAL MICROBIOLOGY: STILL FURTHER HORIZONS
• Section I:Microbial Cultures: Screening,Improvement, Patents
• Chapter 2. NEW ORGANISMS OF ECONOMIC IMPORTANCE: THE CASE OF FRANKIA
• Chapter 3. MIXED CULTURES IN INDUSTRIAL PROCESSES D.E.F. Harrison
• Chapter 4. CULTURES AND PATENTS Roman Saliwanchik
• Chapter 5. PRODUCTION OF PHARMACOLOGICALLY ACTIVE AGENTS FROM MICROBIAL ORIGIN
• Chapter 6. SCREENING OF BASIDIOMYCETES FOR THE PRODUCTION
• Chapter 7. SCREENING OF BACTERIAL ISOLATES FOR ANTIGONOCOCCAL ACTIVITIES
• Chapter 8. ISOLATION OF CARBOXYL PROTEINASES OF MICROBIAL ORIGIN ON PEPSTATIN-SEPHAROSE RESIN
• Chaptre 9. RAPID STRAIN SELECTION FOR CITRIC ACID PRODUCTION
• Chapter 10. USE OF CERULENIN IN SELECTING IMPROVED MUTANTS OF A DAUNORUBICIN-PRODUCING STREPTOMYCETE
• Chapter 11. IMPROVEMENT OF THE DAUNORUBICIN FERMENTATION REALIZED AT 10,000 LITER FERMENTOR SCALE
• Chapter 12. STUDIES ON THE AVERMECTIN FERMENTATION
• Chapter 13. THE INFLUENCE OF OXYGEN CONCENTRATION ON MICROBIAL INSECTICIDE PRODUCTION
• Section II Recombinant DNA and Microbial Genetics
• Chapter 15. EXPANSION OF THE HOST RANGE OF P1 AND Mu PHAGES AND GENE TRANSFER BETWEEN INTERGENERIC BACTERIA
• Chapter 16. STABILITY OF trp OPERON RECOMBINANT PLASMID IN E. c oli
• Chapter 17. GENETIC CONTROL OF DIKARYOTIC FRUITING IN THE BASIDIOMYCETE PLEUROTUS OSTREATUS
• Section III Cell and Tissue Culture -Plant and Animal
• Chapter 19. ASPECTS ON SCALE-UP AND MASS CULTIVATION OF PLANT TISSUE CULTURE
• Chapter 19. ASPECTS ON SCALE-UP AND MASS CULTIVATION OF PLANT TISSUE CULTURE
• Chapter 20. PRESENT AND FUTURE TRENDS IN PLANT TISSUE CULTURE
• Chapter 21. EFFECTS OF MEDIA CONSTITUENTS ON THE FORMATION OF SECONDARY PRODUCTS IN CELL SUSPENSION CULTURES OF CATHARANTHUS ROSEUS
• Chapter 22. HORMONAL REGULATION OF SCOPOLETIN AND SCOPOLIN PRODUCTIONS IN TOBACCO TISSUE CULTURE
• Chapter 23. ENGINEERING CHARACTERIZATION OF ANIMAL CELL AND VIRUS PRODUCTION USING CONTROLLED CHARGE MICROCARRIERS
• Section IV Microbial Oxidation of Hydrocarbons
• Chapter 24. UPTAKE AND OXIDATION OF HYDROCARBONS BY A MUTANT DERIVED FROM ITACONATE-PRODUCING YEAST
• Chapter 25. STUDY OF HYDROXYLASE AND ITS COMPONENTS IN CANDIDA TROPICALIS GROWN ON ALKANE
• Chapter 26. PLASMID INVOLVEMENT IN BACTERIAL DEGRADATION OF PHENANTHRENE
• Chapter 27. INDUCTION OF ENZYMES FOR n-ALKANE DEGRADATION IN TWO STRAINS OF Pseudomonas aeruginosa
• 28. STRUCTURAL CHANGES OF THE TOL PLASMID pWWO
• Chapter 29. UTILIZATION OF N-ALKANES BY MICROORGANISMS:BIOLOGICAL ASPECTS OF TRANSPORT
• Section V Continuous Cultures
• Chapter 31. CONTINUOUS CULTURE - SOME CONTEMPORARY PROBLEMS FROM ANOTHER VIEWPOINT
• Chapter 33. CONTINUOUS CULTURE - ITS INFLUENCE ON ENGINEERING PRACTICE
• Chapter 34. THE ENZYME ACTIVITY AS GROWTH RATE LIMITING STEP IN A CHEMOSTAT
• Chapter 35. SELECTION OF ESCHERICHIA COLI WITH INCREASED ENDOENZYME SYNTHESIS IN CONTINUOUS CULTURE
• Chapter 36. CONTINUOUS PROCESS FOR PRODUCTION OF CITRIC ACID
• Chapter 37. KINETICS OF VIRUS REPLICATION AND GLUCOAMYLASE BIOSYNTHESIS IN ASPERGILLUS NIGER REPEATED FED- BATCH CULTURE
• Chapter 38. AUTO-SELECTION OF VERY RAPIDLY GROWING MICROORGANISMS
• Chapter 39. GEL-FORMING EXOPOLYSACCHARIDE PRODUCTION BY ALCALIGENES FAECALIS GROWN IN NITROGEN-LIMITED CONTINUOUS CULTURE
• Chapter 40. NEW DEVELOPMENTS IN THE ELUCIDATION OF THE MECHANISMS OFTHE PASTEUR AND CRABTREE EFFECTS IN BACTERIA
• Chapter 41. THE CRABTREE EFFECT IN SACCHAROMYCES CEREVISIAE - PRIMARY CONTROL MACHANISM OR TRANSIENT?
• Chapter 42. REGULATORY ASPECTS IN YEAST METABOLISM
• Chapter 43. GROWTH OF HANSENULA POLYMORPHA ON MIXED SUBSTRATES AND REGULATION OF ALCOHOL OXIDASE SYNTHESIS
• Chapter 44. A QUANTITATIVE DESCRIPTION OF THE GROWTH OF SACCHAROMYCES CEREVISIAE CBS 426 IN CONTINUOUS CULTURES ON A MIXTURE OF TWO CARBON SOURCES;
• Chapter 45. CELLULAR YIELDS AND MAINTENANCE REQUIREMENTS OF Alcaligenes Eutrophus DURING HYDROGEN OXIDATION
• Chapter 46. LIGHT SUPPLY AND QUANTUM EFFICIENCIES IN A MODEL REACTOR FOR CONTINUOUS PHOTOTROPHIC GROWTH.
• Chapter 47.PROPERTIES OF THE GREEN ALGA CHLOROGONIUM ELONGATUM DURING LIGHT-LIMITED CONTINUOUS CULTURE IN THE PHAUXOSTAT
• Section VI: Free-Cell Fermentation: Modelling, Simulation and Process Development
• Chapter 49. KINETICS OF SUBSTRATE UTILIZATION IN REPEATED FEDBATCH CULTURE AND FITTING COMPUTER SIMULATION DATA TO EXPERIMENTAL DATA OF ANTIBIOTIC BIOSYNTHESIS
• Chapter 50. A MODEL FOR THE GROWTH AND PRODUCT KINETICS OF FACULTATIVE ANAEROBES BASED ON ATP SYNTHESIS AND CONSUMPTION
• Chapter 51. AN UNSTRUCTURED MODEL OF ALGAL GROWTH IN CONTINUOUS CULTURE
• Capter 52. THE DEVELOPMENT OF A SEMI-SOLID FERMENTATION SYSTEM FOR THE PRODUCTION OF LYSINE-ENRICHED YEAST AND ETHANOL
• Chapter 53. EFFECT OF OXYGEN ON AMINO ACIDS FERMENTATION
• Chapter 54. THE INFLUENCE OF LOW DISSOLVED OXYGEN LEVELS IN FERMENTORS ON ETHANOL PRODUCTION BY CANDIDA TROPICALIS
• Chapter 55. EFFECT OF WATER ACTIVITY ON MlCROBIAL GROWTH
• Chapter 56. DEATH RATES OF BACTERIAL SPORES AT HIGH TEMPERATURE IN A CONTINUOUS STIRRED TANK REACTOR BIREN SRIMANI REINHOLD STAHL AND MARCEL LONCIN
• Section VII: Process Dynamics and Control
• Chapter 57. ANALYSIS OF BASIC PRINCIPLES OF FERMENTATION PROCESS CONTROL
• Chapter 58. PRODUCTION OF CELLULASE IN FED-BATCH CULTURE
• Chapter 59. DYNAMICS AND CONTROL OF A BIOLOGICAL PHENOL WASTEWATER TREATMENT REACTOR
• Chapter 60. THE REDOX POTENTIAL, A HITHERTO SELDOM USED PARAMETER IN FERMENTATION SYSTEMS
• Chapter 61. DETERMINATION OF KINETIC PROCESS PARAMETERS BY DYNAMIC METHODS TAKING INTO ACCOUT THE INERTIA OF MEASURING INSTRUMENT
• Chapter 62. APPLICATION OF EXPERIMENTAL METHODS TO IDENTIFY PROCESS DYNAMICS OF FERMENTATION PROCESSES
• Section VIII Computer Applications in Biotechnology
• Chapter 63. DIRECT MONITORING OF A FERMENTATION IN ACOMPUTER-MASS SPECTROMETER-FERMENTOR SYSTEM
• Chapter 64. STATE ESTIMATION FOR COMPUTER CONTROL OF BIOCHEMICAL REACTORS
• Chapter 65. AN APPROACH TO ON-LINE OPTIMIZATION OF BIOMASS PRODUCTION IN CONTINOUS PROCESSES
• Chapter 66. AUTOMATIC CONTROL OF DISSOLVED OXYGEN CONCENTRATION WITH MICROCOMPUTER
• Chapter 67. ETHANOL· AND RQ-BASED COMPUTER CONTROL IN FED BATCH CULTURE OF BAKER'S YEAST
• Chapter 68. PROGRESS WITH COMPUTER-COUPLED MAMMALIAN CELL CULTURE INVESTIGATIONS
• Section IX Process Instrumentation and Analytical Methods
• Chapter 69. A NEW SENSOR, THE "FILTRATION PROBE", TO| MONITOR AND CONTROL ANTIBIOTIC FERMENTATIONS
• Chapter 70. A POROUS MEMBRANE-CARRIER GAS MEASUREMENT SYSTEM FOR DIS-SOLVED GASES AND VOLATILES IN FERMENTATION SYSTEMS
• Chapter 71. FERMENTER MONITORING AND CONTROL BY ENZYME THERMISTORS
• Chapter 72. MEASUREMENT OF THE SOLUBILITY OF OXYGEN DURING FERMENTATIONS
• Chapter 73. DETERMINATION OF ADENOSINE NUCLEOTIDES WITH LUCIFERIN/LUCIFERASE FROM CRUDE FIREFLY LANTERN EXTRACT ON A BIOLUMINESCENCE ANALYZER
• Chapter 74. PHYSICAL TRANSPORT PHENOMENA IN BUBBLE COLUMN BIO-REACTORS- I. GAS-LIQUID MASS TRANSFER
• Chapter 75. PHYSICAL TRANSPORT PHENOMENA IN BUBBLE COLUMN BIOREACTORS - II. LIQUID-SOLID MASS TRANSFER,MIXING AND HEAT TRANSFER
• ACKNOWLEDGMENT
• Chapter 76. THE TWO-ZONE MODEL: A QUANTITATIVE DESCRIPTION OF THE OXYGEN MASS TRANSFER IN BUBBLE COLUMNS AND THREE-PHASE FLUIDIZED BEDS
• Chapter 77. TURBINE AGITATED GAS DISPERSION: POWER, FLOODING, AND HOLD-UP
• Chapter 78. BUBBLE COALESCENCE AND BREAK-UP IN FERMENTATIONS
• Chapter 79. GAS-LIQUID CONTACTING IN HIGHLY VISCOUS LIQUIDS
• Chapter 80. POWER AND HOLD-UP IN THE MIXING OF AERATED HIGHLY VISCOUS NON-NEWTONIAN FLUIDS
• Chapter 81. GAS ABSORPTION WITH SIMULTANEOUS BIOCHEMICAL
• Chapter 82. SOME SCALE-UP CONSIDERATIONS FOR FERMENTATION MIXERS
• Chapter 83. CIRCULATION TIMES OF VARIOUS FLUIDS IN STIRRED FERMENTORS
• Chapter 84. MODELLING AND SCALE-UP OF ANAEROBIC CONVERSION
• Section XI Unconventional Bioreactors: Design and Operating Characteristics
• Chapter 85. HIGH PRODUCTIVITY ANAEROBIC FERMENTATION WITH DENSE CELL CULTURE
• Chapter 86. MASS TRANSFER AND LIQUID MIXING IN EXTERNAL-CIRCULATIONLOOP CONTACTORS
• Chapter 87. GAS-LIQUID DISPERSION CHARACTERISTICS IN AIRLIFT FERMENTORS
• Chapter 88. LIQUID VELOCITY AS AN IMPORTANT DESIGN PARAMETER FOR AIRLIFT LOOP-FERMENTORS
• Chapter 89. SINGLE AND MULTI-STAGE COUNTERCURRENT BUBBLE COLUMN LOOP REACTOR PERFORMANCES
• Chapter 90. PENICILLIN PRODUCTION IN A BUBBLE COLUMN AIR LIFT LOOP REACTOR
• Chapter 91. OXYGEN TRANSFER AND BIOLOGICAL EFFECTS IN A DEEP-TANK AERATION SYSTEM
• Chapter 92. EFFECTIVENESS OF ENERGY INTRODUCED INTO FERMENTORS
• Chapter 93. NOVEL REACTOR CONFIGURATION FOR SMALL SCALE MICROBIOLOGICAL LEACHING
• Chapter 94. ON-LINE EXTRACTION FERMENTATION PROCESSES
• Chapter 95. MODIFICATION OF NON-NEWTONIAN MYCELIAL FERMENTATION BROTH THROUGH CONFINEMENT OF GROWTH USING MICROSCOPIC BEADS
• Section XII Fixed, Fluidized, and Semi-Fluidized Bed Bioreactors
• Chapter 97. ETHANOL FERMENTATION IN A YEAST IMMOBILIZED COLUMN FERMENTOR
• Chapter 98. FLUIDIZATION PRINCIPLES AND APPLICATIONS TO BIOTECHNOLOGY
• Chapter 99. OXYGEN TRANSFER IN THREE PHASE FLUIDIZED BEDS
• Chapter 100. TAPERED FLUIDIZED BED BIOREACTORS FOR ENVIRONMENTAL CONTROL AND FUEL PRODUCTION
• Chapter 101. FLUIDIZED BED REACTOR FOR THE PRODUCTION OF METHANE FROM SUGAR CANE BAGASSE
• Chapter 102. SEMIFLUIDIZED BED BIOREACTOR
• Section XIII Immobilization Bioreactors
• Chapter 104. DEXTRAN PRODUCTION BY FREE AND IMMOBILIZED DEXTRANSUCRASE
• Chapter 105. IMMOBILIZED ß-GLUCANASE IN BREWING
• Chapter 106. THE EFFECTS OF SOLVENTS ON THE HYDROLYSIS OF LIPIDS BY FREE AND IMMOBILIZED MICROBIAL LIPASE
• Chapter 107. IMMOBILIZATION OF A Penicillium duponti PROTEOLYTIC ENZYME AND ITS APPLICATION IN SOLUBILIZATION OF SOYBEAN PROTEIN IN A SPIRAL-WOUND RECYCLE REACTOR
• Chapter 108. GLUCOAMYLASE HOLLOW-FIBER REACTORS
• Chapter 109. IMMOBILIZED LIVE CELLS
• Chapter 110. MAGNETIC IMMOBILIZED MICROORGANISMS
• Chapter 111. MACROMOLECULAR NAD -DERIVATIVE OF HIGH COENZYME ACTIVITY AND ITS APPLICATION FOR A MODEL REACTION
• Appendices
• APPENDIX IB: OVERVIEW OF TECHNOLOGY TRANSFER AND ECONOMICS II
• APPENDIX II: OVERVIEW OF TRAINING PROGRAMS IN BIOTECHNOLOGY AND BIOCHEMICAL ENGINEERING
• Contents of Other Volumes
• ADVANCES IN BIOTECHNOLOGY
• ADVANCES IN BIOTECHNOLOGY
• CONTENTS OF CURRENT DEVELOPMENTS IN YEAST RESEARCH
• Author Index
• Subject Index