Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Volume 12

M. A. Hayat

• Publisher: Academic Press
• Year: 2017
• Print ISBN: 9780128121467
• eBook ISBN: 9780128121474
• Topic: Medicine
• Subtopic: Immunology

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 12 discusses and details almost all aspects of the autophagy machinery in the context of health, cancer and other pathologies. Autophagy is more widely accepted as beneficial given its role in eliminating 'toxic assets' and promoting cell viability, hence, it has emerged as a new and potent modulator of disease progression that is both scientifically intriguing and clinically relevant. As the latest release in the Autophagy book series, users will find a detailed explanation of the role of molecular mechanisms.- Presents the most advanced information regarding the role of the autophagic system in life and death- States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities- Summarizes the most up-to-date findings on how autophagy is executed and regulated at the molecular level and how its disruption can lead to disease- Authored by global leaders in the field, bringing the broadest, most expert coverage available

Autophagy: Volume 1—Contributions

Mechanisms of Regulation of p62 in Autophagy and Implications for Health and Diseases

Molecular Mechanisms Underlying the Role of Autophagy in Neurodegenerative Diseases

Roles of Multiple Types of Autophagy in Neurodegenerative Diseases

Autophagy and Crohn’s Disease: Towards New Therapeutic Connections

The Role of Autophagy in Atherosclerosis

Treatment of Diabetic Cardiomyopathy through Upregulating Autophagy by Stimulating Amp-Activated Protein Kinase

Hyperglycemia-Associated Stress Induces Autophagy: Involvement of the Ros-ERK/JNK-P53 Pathway

Role of Autophagy in the Cellular Defense Against Inflammation

Mytophagy Plays a Protective Role in Fibroblasts from Patients with Coenzyme Q10 Deficiency

Presence of Dioxin Kidney Cells Induces Cell Death with Autophagy

Molecular Mechanisms Underlying the Activation of Autophagy Pathways by Reactive Oxygen Species and their Relevance in Cancer Progression and Therapy

Induction of Autophagic Cell Death by Anticancer Agents

Immunogenicity of Dying Cancer Cells—The Inflammasome Connection

Autophagic Death Arrives to the Scene

Selenite-Mediated Cellular Stress, Apoptosis, and Autophagy in Colon Cancer Cells

Enhancement of Cell Death in High Grade Glioma Cells: Role of N-(4-Hydroxyphenyl) Retinamide-Induced Autophagy

Cisplatin Exposure of Squamous Cell Carcinoma Cells Leads to the Modulation of Autophagic Pathway

Autophagy, Stem Cells, and Tumor Dormancy

Death-Associated Protein Kinase 1 Suppresses Tumor Growth and Metastasis via Autophagy and Apoptosis

TRIM13, Novel Tumor Suppressor: Regulator of Autophagy and Cell Death

Hypoxia-Induced Autophagy Promotes Tumor Cell Survival

Autophagy: Volume 2—Contributions

Selective Autophagy: Role of Interaction Between the Atg8 Family

Mammalian Autophagy can Occur through an Atg5/Atg7-Independent Pathway

Selective Autophagy: Role of Ubiquitin and Ubiquitin-Like Protein in Targeting Protein Aggregates, Organelles, and Pathogen

Ubiquitin and p62 in Selective Autophagy in Mammalian Cells

Role of the Golgi Complex and Autophagosome Biogenesis in Unconventional Protein Secretion

Induction of Autophagy in HIV-1-Unifected Cells: Role of Fusogenic Activity of GP41

Non-Lipidated LC3 Is Essential for Mouse Hepatitis Virus Infection

Suppression of Innate Antiviral Immunity after Hepatitis C Virus Infection: Role of the Unfolded Protein Response and Autophagy

Mycobacterial Survival in Alveolar Machophages as a Result of Coronin-1A Inhibition of Autophagosome Formation

Virulent Mycobacteria Upregulate Interleukin-6 (IL-6) Production to Combat Innate Immunity

Autophagy in Parasitic Protists

Cell Surface Pathogen Receptor Cd46 Induces Autophagy

Helicobacter Pylori Infection and Autophagy: A Paradigm for Host-Microbe Interactions

Autophagy Is Required during Monocyte-Macrophage Differentiation

Role of Autophagy Gene Atg5 in T Lymphocyte Survival and Proliferation

Sepsis Induced Autophagy Is a Protective Mechanism against Cell Death

Blockage of Lysosomal Degradation Is Detrimental to Cancer Cells Survival: Role of Autophagy Activation

Autophagy as a Sensitization Target in Cancer Therapy

Pathogenesis of Bile Duct Lesions in Primary Biliary Cirrhosis: Role of Autophagy Followed by Cellular Senescence

Autophagy and NADPH Oxidase Activity Tends to Regulate Angiogenesis in Pulmonary Artery Endothelial Cells with Pulmonary Hypertension

Role of Autophagy in Heart Disease

Regulation of Autophagy in Obesity-Induced Cardiac Dysfunction

Cytochrome P4502E1, Oxidative Stress, JNK, and Autophagy in Acute Alcohol-Induced Fatty Liver

Autophagy-Independent Tumor Suppression: Role of UVRAG

Chaperone-Mediated Autophagy and Degradation of Mutant Huntingtin Protein

The Role of Atg8 Homologue in Lewy Disease

Autophagy: Volume 3—Contributions

Autophagic Flux, Fusion Dynamics, and Cell Death

Architecture of the ATG12-ATG5-ATG16 Complex and its Molecular Role in Autophagy

The Molecular Mechanisms Underlying Autophagosome Formation in Yeast

Role of Autophagy in Cell Survival in Liver Injury

Polymorphisms in Autophagy-Related Genes in Crohn’s Disease: Impact on Intracellular Bacteria Persistence and Inflammatory Response

Functional Relevance of Autophagins in Life and Disease

Strategies to Block Autophagy in Tumour Cells

Autophagic Dysfunction in Gaucher Disease and its Rescue by Cathepsin B and D Proteases

Cargo Recognition Failure Underlies Macroautophagy Defects in Huntington’s Disease

Hepatitis C Virus Infection, Autophagy, and Innate Immune Response

Geranylgeranoic Acid Induces Incomplete Autophagy but Leads to the Accumulation of Autophagosomes in Human Hepatoma Cells

Defense Against Proteotoxic Stress in the Heart: Role of p62, Autophagy, and Ubiquitin-Proteasome System Elimination of Intracellular Bacteria by Autophagy

Protein Phosphatase 2A Has Positive and Negative Roles in Autophagy

Erufosine Induces Autophagy and Apoptosis in Oral Squamous Cell Carcinoma: Role of the Akt-mTOR Signaling Pathway

Emerging Role of Hypoxia-Induced Autophagy in Cancer Immunotherapy

Involvement of Autophagy and Apoptosis in Studies of Anticancer Drugs

Autophagy-Based Protein Biomarkers for In Vivo Detection of Cardiotoxicity in the Context of Cancer Therapy

Inhibition of mTOR Pathway and Induction of Autophagy Block Lymphoma Cell Growth: Role of Ampk Activation

Autophagy Regulates Osteoarthritis-Like Gene Expression Changes: Role of Apoptosis and Reactive Oxygen Species

The Key Role of Autophagy and its Relationship with Apoptosis in Lepidopteran Larval Midgut Remodeling

Interferon Regulatory Factor 1 Regulates both Autophagy and Apoptosis in Splenocytes During Sepsis

The Interplay Between Autophagy and Apoptosis

Autophagy: Volume 4—Contributions

Molecular Process and Physiological Significance of Mitophagy

Principles of Mitophagy and Beyond

Quality Control in Mitochondria

Mitophagy: An Overview

Mitophagy Induction and Curcumin-Mediated Sonodynam...

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• Dedication
• Dedication
• Knowing Autophagy
• 10 Lines of Autophagy for Volume 10
• Mitophagy and Biogenesis
• Dedication
• Autophagy and Cancer
• Some Thoughts on Autophagy and Immunity
• Autophagy: Friend or Foe?
• Autophagy: If and When
• What Happened When Autophagy Didn’t
• Sugar Isn’t Always Sweet
• Mitochondrial Mysteries
• A Photo Is Static, An Instant in Time
• Autophagy Subversion
• An Autophagy a Day
• Foreword
• Foreword
• Preface
• Contributors
• Autophagy: Volume 1—Contributions
• Autophagy: Volume 2—Contributions
• Autophagy: Volume 3—Contributions
• Autophagy: Volume 4—Contributions
• Autophagy: Volume 5—Contributions
• Autophagy: Volume 6—Contributions
• Autophagy: Volume 7—Contributions
• Autophagy: Volume 8—Contributions
• Autophagy: Volume 9—Contributions
• Autophagy: Volume 10—Contributions
• Autophagy: Volume 11—Contributions
• Chapter 1. Overview of Autophagy
• Chapter 2. The Role of Autophagy in Aging: Molecular Mechanisms
• Chapter 3. The Role of p62 in Aggregopathies
• Chapter 4. Role of Autophagy in the Transition From Monocyte to Differentiation
• Chapter 5. Cdc48 AAA ATPase Regulates Protein Dynamics and Turnover in Mitochondria
• Chapter 6. Autophagy in Plasma Cells
• Chapter 7. Loss of PINK1 or Parkin Function Results in a Progressive Loss of Mitochondrial Function
• Chapter 8. Role of the Transcription Factor Interferon Regulatory Factor-1 in Regulating Autophagy in Lipopolysaccharide-Stimulated Macrophages
• Chapter 9. Mechanistic Target of Rapamycin: The Alpha and Omega of Autophagy Regulation
• Chapter 10. ER-Phagy in Starvation, ER Stress, and Quality Control
• Chapter 11. Role of Autophagy Inhibition in Tumor Proliferative Arrest
• Chapter 12. Survival at the Brink: Chromatin Autophagy of Tumor Cells in Response to Genotoxic Challenge
• Chapter 13. Loss of Autophagy in Hypothalamic Neurons May Be Involved in the Pathogenesis of Obesity
• Chapter 14. Defective Autophagy in Mesenteric Fat Tissue Maintains Inflammation in Crohn’s Disease
• Chapter 15. Autophagy Regulates Inflammatory Responses in Antigen-Presenting Cells: Underlying Mechanisms
• Chapter 16. Autophagy Accompanies Inflammasome Activation to Moderate Inflammation by Eliminating Active Inflammasomes
• Chapter 17. Autophagy, Inflammation, and Breast Cancer Risk
• Chapter 18. AMBRA1-Mediated Regulation of C-MYC and Its Relevance to Cancer
• Chapter 19. The Delicate Balance of Autophagy in Neurodegeneration
• Chapter 20. Silibinin Protects Ultraviolet B–Irradiated Skin by Balancing Apoptosis and Autophagy in Epidermis and Dermis
• Chapter 21. Role of Autophagy Activation in Alleviating Alcohol Neurotoxicity
• Chapter 22. Lipopolysaccharide-Enhanced Bactericidal Activity is Mediated by Induction of the Autophagosomal Process
• Chapter 23. Role of Autophagy in Liver Regeneration
• Chapter 24. A Dual Role of a Soluble N-Ethylmaleimide Sensitive Factor–Attachment Protein Alpha (αSNAP) in the Regulation of Autophagy
• Chapter 25. Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Induces Autophagic Protein Cleavage in Melanoma Cells
• Abbreviations and Glossary
• Index