Therapeutic Targets in Airway Inflammation

N. Tony Eissa, David P. Huston, N. Tony Eissa, David P. Huston

• Publisher: CRC Press
• Year: 2003
• eBook ISBN:
  9781135532369
• Topic: Medicine
• Subtopic: Clinical Medicine

This reference examines the cellular, molecular, and genetic mechanisms involved in airway inflammation, as well as the pathophysiology, epidemiology, and aetiology of asthma. It explores strategies to prevent cellular injury and oxidative tissue damage, inhibit key inflammatory pathways and identify disease-specific targets to reduce the induction

Table of contents

• Cover Page
• Title Page
• Lung Biology In Health And Disease
• Introduction
• Preface
• Contributors
• Table of Contents
• 1 Pathophysiology of Airway Inflammation in Asthma
• 2 Primary Human Lung Cells in the Evaluation of Airway Inflammation
• 3 Airway pH Homeostasis in Asthma and Other Inflammatory Lung Diseases
• 4 Monitoring of Exhaled Breath to Assess Airway Inflammation in Asthma
• 5 The Modulatory Effects of Carbon Monoxide on the Inflammatory Response
• 6 Reactive Nitrogen Species and Tyrosine Nitration in Airway Inflammation
• 7 S-Nitrosothiols in Lung Inflammation
• 8 Contribution of Nitric Oxide Synthase Isoforms to Allergen-Induced Airway Hyperresponsivenessand Inflammation
• 9 Molecular Mechanisms of Increased Nitric Oxide in Airway Inflammation
• 10 Regulation of Nitric Oxide Synthesis by Inducible Nitric Oxide Synthase
• 11 Novel Strategies for Selective Inhibition of Inducible Nitric Oxide Synthase
• 12 Leukocyte Recruitment in Allergic Pulmonary Inflammation
• 13 Neutrophil Emigration in the Lungs
• 14 Dendritic Cells
• 15 Roles of Mast Cells in Airway Hyperreactivity, Inflammation and Remodeling,and Immunoregulation in Asthma
• 16 Mast Cell Exocytosis in Airway Inflammation
• 17 Mast Cell Proteases
• 18 Peroxidases and Asthma
• 19 Chemokines in Allergic Airway Inflammation
• 20 Role of the Eotaxin Subfamily of Chemokines in Allergic Eosinophilic Inflammation
• 21 Interleukin-4 and Interleukin-13 in Human and Experimental Asthma
• 22 Interleukin-5 and Eosinophils as Therapeutic Targets for the Treatment of Asthma
• 23 Modulating the Interleukin-5 Response in Asthma
• 24 The Role of Interleukin-9 in Allergic Inflammation of Asthma
• 25 Epithelial Production of IL-12 p80 During Viral Infection and Asthma Supports an Altered Paradigmfor Airway Inflammation
• 26 Interleukin-16 and Airway Hyperresponsiveness in Asthma
• 27 Modulation of the Allergic Response
• 28 Inhibition of Cytokine Signaling
• 29 Eicosanoids as Mediators and Therapeutic Targets in Airway Inflammation
• 30 Nitric Oxide, Reactive Nitrogen Species, and Lipid Mediator Generation in the Lung
• 31 Adenosine Signaling and Lung Inflammation
• 32 Complement Factor 5 in Asthma
• 33 Complement Anaphylatoxin Receptors in Asthma
• 34 Inflammatory and Structural Changes in Airway Remodeling of Asthma
• 35 The Role of Proteases in Airway Remodeling
• 36 Airway Smooth Muscle
• 37 Cellular Trafficking of ß2-Adrenergic Receptors
• 38 Genetic Targets in Asthma
• 39 Application of Pharmacogenetics to the Therapeutics of Asthma
• 40 DNA-Based Immunotherapy for Asthma
• 41 Allergen Immunotherapy
• 42 Peptide-Based Therapy for Asthma
• 43 Reducing IgE Levels as a Strategy for the Treatment of Asthma
• 44 Strategies to Reduce Excessive Mucus Secretion in Airway Inflammation
• Index