Etiology, Pathogenesis and Pathophysiology of Aortic Aneurysms and Aneurysm Rupture

Reinhart Grundmann

• Publisher: IntechOpen
• Year: 2011
• Print ISBN:
  9789533075235
• eBook ISBN:
  9789535164401
• Topic: Medicine
• Subtopic: Cardiology

This book considers mainly etiology, pathogenesis, and pathophysiology of aortic aneurysms (AA) and aneurysm rupture and addresses anyone engaged in treatment and prevention of AA. Multiple factors are implicated in AA pathogenesis, and are outlined here in detail by a team of specialist researchers. Initial pathological events in AA involve recruitment and infiltration of leukocytes into the aortic adventitia and media, which are associated with the production of inflammatory cytokines, chemokine, and reactive oxygen species. AA development is characterized by elastin fragmentation. As the aorta dilates due to loss of elastin and attenuation of the media, the arterial wall thickens as a result of remodeling. Collagen synthesis increases during the early stages of aneurysm formation, suggesting a repair process, but resulting in a less distensible vessel. Proteases identified in excess in AA and other aortic diseases include matrix metalloproteinases (MMPs), cathepsins, chymase and others. The elucidation of these issues will identify new targets for prophylactic and therapeutic intervention.

Table of contents

• Etiology, Pathogenesis and Pathophysiology of Aortic Aneurysms and Aneurysm Rupture
• Contents
• Preface
• Chapter 1 Etiology and Pathogenesis of Aortic Aneurysms
• Chapter 2 Matrix Metalloproteinases in Aortic Aneurysm – Executors or Executioners?
• Chapter 3 Mast Cell Density and Distribution in Human Abdominal Aortic Aneurysm
• Chapter 4 The Role of Complement in the Pathogenesis of Artery Aneurysms
• Chapter 5 Immunoglobulin G4-Related Inflammatory Aortic Aneurysm
• Chapter 6 Transcriptomic and Proteomic Profiles of Vascular Cells Involved in Human Abdominal Aortic Aneurysm
• Chapter 7 Multifaceted Role of Angiotensin II in Vascular Inflammation and Aortic Aneurysmal Disease
• Chapter 8 Aortitis and Aortic Aneurysm in Systemic Vasculitis
• Chapter 9 Drug-Induced Aortic Aneurysms, Ruptures and Dissections
• Chapter 10 Pathophysiology of Abdominal Aortic Aneurysm Rupture and Expansion: New Insight on an Old Problem
• Chapter 11 An Analysis of Blood Flow Dynamics in AAA
• Chapter 12 Numerical Simulation in Aortic Arch Aneurysm