Tumor Suppressor Genes

Yue Cheng

• Publisher: IntechOpen
• Year: 2012
• Print ISBN: 9789533078793
• eBook ISBN: 9789535167440
• Topic: Medicine
• Subtopic: Oncology

Functional evidence obtained from somatic cell fusion studies indicated that a group of genes from normal cells might replace or correct a defective function of cancer cells. Tumorigenesis that could be initiated by two mutations was established by the analysis of hereditary retinoblastoma, which led to the eventual cloning of RB1 gene. The two-hit hypothesis helped isolate many tumor suppressor genes (TSG) since then. More recently, the roles of haploinsufficiency, epigenetic control, and gene dosage effects in some TSGs, such as P53, P16 and PTEN, have been studied extensively. It is now widely recognized that deregulation of growth control is one of the major hallmarks of cancer biological capabilities, and TSGs play critical roles in many cellular activities through signaling transduction networks. This book is an excellent review of current understanding of TSGs, and indicates that the accumulated TSG knowledge has opened a new frontier for cancer therapies.

Table of contents

• Tumor Suppressor Genes
• Contents
• Preface
• Chapter 1 Tumor Suppressor Gene p16/INK4A/CDKN2A and Its Role in Cell Cycle Exit, Differentiation, and Determination of Cell Fate
• Chapter 2 Susceptibility of Epithelium to PTEN-Deficient Tumorigenesis
• Chapter 3 Identification of Tumor Suppressor Genes via Cell Fusion and Chromosomal Transfer
• Chapter 4 TP53 Gene Polymorphisms in Cancer Risk: The Modulating Effect of Ageing, Ethnicity and TP53 Somatic Abnormalities
• Chapter 5 Epigenetics and Tumor Suppressor Genes
• Chapter 6 Therapeutic Targeting of p53-Mediated Apoptosis Pathway in Head and Neck Squamous Cell Carcinomas: Current Progress and Challenges
• Chapter 7 Signaling Mechanisms of Transforming Growth Factor-β (TGF-β) in Cancer: TGF-β Induces Apoptosis in Lung Cells by a Smad-Dependent Mechanism
• Chapter 8 Refining the Role of Lgl, Dlg and Scrib in Tumor Suppression and Beyond: Learning from the Old Time Classics
• Chapter 9 Epigenetic and Posttranscriptional Alterations of Tumor Suppressor Genes in Sporadic Pituitary Adenomas
• Chapter 10 Genomic and Expression Alterations of Tumor Suppressor Genes in Meningioma Development, Progression and Recurrence
• Chapter 11 Control of Retinal Development by Tumor Suppressor Genes
• Chapter 12 Properties of Human Tumor Suppressor 101F6 Protein as a Cytochrome b561 and Its Preliminary Crystallization Trials
• Chapter 13 Epigenetic Control of Tumor Suppressor Genes in Lung Cancer