Protein-Protein Interactions

Computational and Experimental Tools

Weibo Cai, Hao Hong, Weibo Cai, Hao Hong

• Publisher: IntechOpen
• Year: 2012
• Print ISBN: 9789535103974
• eBook ISBN: 9789535143123
• Topic: Biological Sciences
• Subtopic: Biochemistry
• Index: Biological Sciences

Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.

Table of contents

• Protein-Protein Interactions - Computational and Experimental Tools
• Contents
• Preface
• Part 1 Computational Approaches
• Part 2 Experimental Approaches
• Part 3 Others Chapter 19 Computational Tools and Databases for the Study and Characterization of Protein Interactions