Mutagenesis
About this book
The complexity of problem understanding biochemical and molecular basis of healthy life, and eagerness to find simple solution necessitate evolution of technology like mutagenesis. The chapters of this book contain experiences of scientists working in the area of mutagenesis. It describes suitable experimental models (microorganism, plants or animals) for testing spontaneous and induced mutations which are useful for basic and translational research. It includes methods towards gene targeting, developing disease and pest resistant plants, creating temperature sensitive molecular machines, understanding mitochondrial mutagenesis, detecting anti-mutagens, improving genetic insight into impaired immunity and disease. It also describes mutagenesis induced by DNA damage. It has also provided advantage of in vitro transcription and translation to yield proteins with point mutations, deletions or insertions for studying stability, DNA-protein or protein-protein interaction. Trust, it will serve readers as valuable integrated resources emphasizing methods of mutagenesis, and understanding mechanism of variable penetrance or expressivity of mutations.
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Table of contents
- Mutagenesis
- Contents
- Preface
- Chapter 1 Mutagenesis: A Useful Tool for the Genetic Improvement of the Cultivated Peanut (Arachis hypogaea L.)
- Chapter 2 Mono-Ubiquitination of Nuclear Annexin A1 and Mutagenesis
- Chapter 3 Models for Detection of Genotoxicity in vivo: Present and Future
- Chapter 4 Mitochondrial Mutagenesis in Aging and Disease
- Chapter 5 Molecular Mechanisms of Action of Antimutagens from Sage (Salvia officinalis) and Basil (Ocimum basilicum)
- Chapter 6 Chemical Modification of Oligonucleotides: A Novel Approach Towards Gene Targeting
- Chapter 7 The Mutation of Transient Receptor Potential Vanilloid 4 (TRPV4) Cation Channel in Human Diseases
- Chapter 8 Bacterial Systems for Testing Spontaneous and Induced Mutations
- Chapter 9 ENU Mutagenesis in Mice – Genetic Insight into Impaired Immunity and Disease
- Chapter 10 Mutagenesis in Plant Breeding for Disease and Pest Resistance
- Chapter 11 Mutagenesis and Temperature-Sensitive Little Machines