Autoimmunity

Pathogenesis, Clinical Aspects and Therapy of Specific Autoimmune Diseases

Katerina Chatzidionysiou

• Publisher: IntechOpen
• Year: 2015
• Print ISBN:
  9789535121343
• eBook ISBN:
  9789535172413
• Topic: Medicine
• Subtopic: Immunology

Autoimmunity is defined as an immune response against a self-antigen. This abnormal immune response can lead to tissue damage and to the development of autoimmune disease. From organ-specific autoimmune diseases, such as myasthenia gravis, to non-organ-specific, such as systemic lupus erythematosus, autoimmune diseases represent a heterogeneous group of disorders which affect approximately 6% of the population. The pathogenesis of many autoimmune diseases is complex and remains not completely understood. The aim of this book is to present current knowledge regarding pathogenic mechanisms of autoimmune diseases, clinical aspects of specific autoimmune diseases, like vitiligo, celiac disease and autoimmune liver disease, as well as insights regarding specific therapies.

Table of contents

• Autoimmunity - Pathogenesis, Clinical Aspects and Therapy of Specific Autoimmune Diseases
• Contents
• Preface
• Chapter 1 Crosstalk Between Oxidative Stress, Autophagy and Cell Death — Pathogenesis of Autoimmune Disease
• Chapter 2 Role of C1q in Efferocytosis and Self-Tolerance — Links With Autoimmunity
• Chapter 3 Implication of Regional Activation of Toll-Like Receptor 3/ Interferon-β Signaling in Human Mesangial Cells — Possible Involvement in the Pathogenesis of Lupus Nephritis
• Chapter 4 Autoimmunity in Children with Primary Immunodeficiency – Diagnosis, Management and Therapy
• Chapter 5 A Concise Review of Autoimmune Liver Diseases
• Chapter 6 Celiac Disease and Other Autoimmune Disorders
• Chapter 7 Vitiligo – A Complex Autoimmune Skin Depigmenting Disease
• Chapter 8 Will Understanding Methotrexate Modes of Action Teach us About Rheumatoid Arthritis?