Progress in Understanding Cystic Fibrosis

Dinesh Sriramulu

• Publisher: IntechOpen
• Year: 2017
• Print ISBN:
  9789535132912
• eBook ISBN:
  9789535147367
• Topic: Medicine
• Subtopic: Genetics in Medicine

Congenital defects in humans are of greater concern, and in that line, cystic fibrosis (CF) has been one of the most complex diseases posing treatment challenge till date. Though it is a chronic condition, CF is closely associated with dysfunction of various organ systems of the human body, which in turn results in secondary infections by microbes. Decades of research by scientists worldwide has narrowed down the cause of CF to a single target gene. But the complexity of the disease is the prime impediment to finding a single-shot cure. Fortunately, the multidisciplinary approach toward understanding and management of the CF condition has certainly increased the level of life expectancy among CF patients. In particular, the "omics" and the "systems biology" approach have greatly widened the focal area for better understanding of the disease. This book includes a collection of interesting chapters contributed by eminent scientists around the world who have been striving to improve the life of those affected by CF.

Table of contents

• Progress in Understanding Cystic Fibrosis
• Contents
• Preface
• Chapter 1 CFTR Involvement in Cell Migration and Epithelial Restitution
• Chapter 2 Cystic Fibrosis–Related Diabetes
• Chapter 3 The Cystic Fibrosis Airway Microbiome and Pathogens
• Chapter 4 Burkholderia cepacia Complex Infections Among Cystic Fibrosis Patients: Perspectives and Challenges
• Chapter 5 Pseudomonas aeruginosa Extracellular Secreted Molecules Have a Dominant Role in Biofilm Development and Bacterial Virulence in Cystic Fibrosis Lung Infections
• Chapter 6 Structure‐Function Relationships of Rhamnolipid and Exopolysacharide Biosurfactants of Pseudomonas aeruginosa as Therapeutic Targets in Cystic Fibrosis Lung Infections
• Chapter 7 Anti‐PcrV Immunization for Pseudomonas aeruginosa Pneumonia in Cystic Fibrosis