Progress in Tryptophan and Serotonin Research

Proceedings. Fourth Meeting of the International Study Group for Tryptophan Research ISTRY, Martinsried, Federal Republic of Germany, April 19-22, 1983

H. G. Schlossberger, H. Steinhart, W. Kochen, B. Linzen, International Study Group for Tryptophan Research, H. G. Schlossberger, H. Steinhart, W. Kochen, B. Linzen, International Study Group for Tryptophan Research

• Publisher: De Gruyter
• Year: 2019
• Print ISBN: 9783110097603
• eBook ISBN: 9783111641546
• Edition: 1
• Topic: Biological Sciences
• Subtopic: Chemistry
• Index: Biological Sciences

Table of contents

• Preface
• CONTENTS
• OPENING SESSION
• Adolf Butenandt's Work on the Metabolism of Tryptophan
• Tryptophan, the Heart of the Toxic Peptides from Amanita Mushrooms
• Forty Years of Trypto-Fun
• Indoleamine Dioxygenase - a Possible Biological Function
• QUALITATIVE AND QUANTITATIVE ANALYSIS OF TRYPTOPHAN AND ITS METABOLITES
• Liquid Chromatography/Electrochemistry Determination of Biogenic Amines: Improved Performance Using Low Dead Volume Multiple Electrode Transducers
• GLC and HPLC Analysis of Tryptophan, Kynurenine and Related Metabolites
• Monitoring of Tryptophan Levels in Biological Fluids by HPLC: An Improved Method
• Rapid Determination of Tryptophan and its Metabolitesalong the Kynurenine Pathway by HPLC
• HPLC-Analysis of Xanthurenic Acid and its 8-Methyl-Ether
• Free and Total Tryptophan Microdetermination by an Automated Fluorometric Method
• Comparison of HPLC and GC-MS Methods for the Determination of Tryptophan and its Indole Metabolites in Biological Samples
• Pineal Indoles: Their Determination by High Performance Liquid Chromatography and the Influence of Diurnal Variation and Tryptophan Administration on their Level in the Rat
• Higher-Order Derivative Spectrophotometry for the Quantitative Determination of Tryptophan, Tyrosine and Phenylalanine in Two- and Three-Component Mixtures, Peptides and Proteins
• The Application of a Spectrofluorometer-Optical- Multichannel Analyzer System to the Determination of Tryptophan
• Picomole Determination of Tryptophan by Derivatization to 9-Hydroxymethyl-ß-Carboline
• Determination of Tryptophan in Food after Alkaline Hydrolysis: An Evaluation
• Colorimetric Determination of Tryptophan in Corn-Cob Mix (CCM)
• Comparison of Tryptophan Assays for Food Proteins
• WORKSHOP: ANALYSIS OF TRYPTOPHAN
• Discussion at the Workshop on "Analysis of Tryptophan"
• TRYPTOPHAN AND SEROTONIN: NEUROBIOLOGY
• Tryptophan Transport to the Brain: Newer Findings and Older Ones Reconsidered
• Tryptophan Availability and Serotonin Synthesis in Rat Brain: Effects of Experimental Diabetes
• Anatomy and Function of Central Serotoninergic Neurons
• Serotonin Receptor Binding Sites: Localization and Role in the Brain and Peripheral Tissues
• Involvement of 5-HT₂(S₂)- Receptor Sites in the Serotonin-Induced Activation of Cat Platelets
• The Regulation of 5-Hydroxytryptamine Release from Superfused Synaptosomes by Tryptophan
• Selective Increases in High Affinity Tryptophan Transport in Synaptosomes from Different Brain Areas Incubated in Sodium-Free Media
• Formation and Function of Tetrahydro-ß-Carbolines with Special Reference to their Action on [3H] - Tryptamine Binding Sites
• Regulations of Serotonergic Neurons Innervating the Basal Ganglia: In vivo Release Studies
• Blood Platelets as Models for Neurons: Similarities of the 5-Hydroxytryptamine Systems
• In vivo Metabolism of ¹⁴C-5-HT, ¹⁴C-5.6-DHT and ¹⁴C-5.7-DHT by MAO/COMT/Aldehyde Dehydrogenase in Rat Brain
• Tryptophan Metabolism in the Pineal Gland
• Some Physiological Responses and Effects of the Pineal Indoleamine Melatonin
• Pharmacologic Regulation of Serum N-Acetylserotonin
• N-Acetyltryptophan: Biochemical and Pharmacological Studies
• Serotonin, a Major Metabolite of Tryptophan in the Rabbit Retina
• Effect of 5-Hydroxyanthranilic Acid on Arachidonate Metabolites Function in Platelet Aggregation System
• WORKSHOP: CLINICAL AND BEHAVIOURAL EFFECTS OF TRYPTOPHAN
• Introduction to Workshop
• Tryptophan and Human Sleep: An Analysis of 43 Studies
• L-Tryptophan in Chronic Insomnia
• Tryptophan (500 mg) Decreases Subjectively Perceived Sleep Latency and Increases Sleep Depth in Man
• Further Evidence of the Hypnotic Properties of Tryptophan
• The Therapeutic Action of Tryptophan in Depression, Mania, and Aggression
• The Effects of Dietary Tryptophan on Chronic Maxillofacial Pain Tolerance
• PATHOLOGY, CLINICAL ASPECTS
• Modulation of Serotonin Receptors by L-Valine in Hepatic Encephalopathy
• Effect of a B-Vitamin on Tryptophan Metabolism in South African Bantu with Pellagra
• Studies on the Urinary Excretion of Xanthurenic Acid in Diabetics
• Urinary Excretion of Xanthurenic Acid and Zinc in Diabetes
• Studies of the Clinical Importance and Molecular Defect of Hereditary Vitamin B₆ Dependent Xanthurenic Aciduria
• Tryptophan - Nicotinic Acid Pathway in Cardiovascular Diseases
• The Dependence of Stress Induced Increases in Functional 5HT Activity on Increased Tryptophan Availability: Evidence that in vivo Electrochemistry Monitors 5-Hydroxyindole Release
• Increased Availability of Tryptophan to the Brain in Stress is not Mediated via Changes in Competing Amino Acids
• Free and Bound Plasma Tryptophan Levels in Psychiatric Disorders
• Cerebrospinal Fluid 5HIAA and Tryptophan in Depression and Suicide
• The Influence of L5-Hydroxytryptophan (L5-HTP) on Clinical and Biochemical Parameters in Depressive Patients
• Plasma Tryptophan Levels and 5-Hydroxytryptamine Synthesis in the Brain and the Spinal Cord in "Arthritic" Rats
• Effects of Antirheumatic Drugs and Tricyclic Antidepressants on Total and Free Serum Tryptophan Levels in Arthritic Rats
• Tryptophan, Serotonin and 5-Hydroxyindoleacetic Acid Levels in Human CSF in Relation to Pain
• Dynamics of Plasma Tryptophan Following Antimigraine Drugs
• Comparison of Morphine and Meptazinol Effects on Rat Tryptophan Disposition and Metabolism
• Decreased Concentrations of Tryptophan and Serotonin in the Brain of Developing Hyperphenylalaninemic Rats - A Contribution to the Understanding of the Metabolic Effects in Phenylketonuria
• Cofactor Dependency of Serotonin and Catecholamine Biosynthesis in Patients with Atypical Phenylketonuria and Endogenous Depression
• Tryptophan, 5-Hydroxytryptophan and Dopa Metabolism in the Rat with Experimental Phenylketonuria
• The Role of Tryptophan Oxidation in Ocular Tissue Damage
• Tryptophan and Kynurenine in Senile Cataract
• Urinary 5-Hydroxyindoleacetic Acid and Serum Phénobarbital of Children Suffering from Epilepsy
• Anticonvulsant Drugs Produce Different Effects on Plasma Tryptophan Concentrations in Epileptic Patients
• The Role of Metabolism in 3-Methylindole-Induced Acute Lung Injury
• Beta-Carboline Levels in Blood of Smokers and Non-Smokers
• The Relationship between Tryptophan, Tryptophan Metabolites and Bladder Cancer
• Role of Indoleamine 2,3-Dioxygenase in the Defence Mechanism against Tumor Growth
• The Relationship between Plasma Kynurenine and Indoleamine 2,3-Dioxygenase Activity in the Extrahepatic Tissues
• L-Tryptophan Metabolism along the Kynurenine Pathway in Human Malignant Melanoma
• NUTRITIONAL ASPECTS
• Content and Stability of Tryptophan in Foods
• Increased Aromatic Amine (Kynurenine) in Dried Fish Meat under Sunlight
• Tryptophan Requirement of Farm Animals
• Pattern of Radioactivity from Endogenous 3H-Tryptophan Excreted in the Urine of Fasted or Rats Fed Diets Containing Different Levels of Casein
• Protein/Carbohydrate Selection in Rats Following Administration of Tryptophan, Glucose or a Mixture of Amino Acids
• Influence of Tryptophan on Gastric Mucosal Protein Synthesis
• Tryptophan and Intestinal Secretion
• Tryptophan Metabolism in Undernourished Developing Rat Brain
• Effect of Tryptophan on Protein Utilization and Energy Intake of Pigs
• A High Carbohydrate, Protein-Free Meal, either at Breakfast or in the Evening Does not Alter Plasma Tryptophan to Large Neutral Amino Acid Ratios in Healthy Men
• Effects of Large Neutral Amino Acids on Tryptophan Transport into the Brain during Development
• Contribution of Exegenous N¹⁵-Tryptophan to Plasma and Red Blood Cell Tryptophan and Kynurenine in Healthy Humans
• Carbohydrate Meal Increases Brain 5-Hydroxytryptamine Synthesis in the Adult Rat only after Prolonged Fasting
• Exogenous Tryptophan: A Study of its Effects on the Levels of Aromatic Amine(s) in Cerebral and Hepatic Tissues in Mice
• Influence of Excess Leucine Intake on the Conversion of Tryptophan to NAD in Rats Fed Low Protein Diet
• The Pellagragenic Action of a Dietary Excess of Leucine: Effects of a High-Leucine Diet on Tryptophan Metabolism
• Effect of Cadmium on some Key Enzymes of Tryptophan - NAD Pathway in Rats in vivo
• The Influence of Increased Availability of Tryptophan on the Formation of Tryptamine and Serotonin during Early Ontogenesis
• TRYPTOPHAN METABOLISM IN MAMMALS
• Tryptophan Metabolism and its Control in Mammalian Liver
• Tryptophan Metabolism by the Isolated, Perfused Liver and Kidney of Rat (Quantification of the Metabolism by the Compartmental Analysis)
• Effects of Oestrogens on the Metabolism of Tryptophan Implications for the Interpretation of the Tryptophan Load Test for Vitamin B₆Nutritional Status
• The Functions and Regulation of Tryptophan Pyrrolase
• Kynurenine Aminotransferase Activity in Human and other Mammalian Tissues
• Intracellular Localization and Characterization of 3-Hydroxykynureninase in Human Liver
• Time-Course of 5-HTP Metabolism in Rabbits: Relevance of Transaminating Pathway
• Tryptophan Aminotransferase Activity in Rat Liver
• The Oxygenation of Tryptophan and Indoles with Superoxide Ion and Dioxygen in the Presence of Copper and Ruthenium Catalysts
• Serotonin- and Melatonin-Dependent Light Emission Induced by Xanthine Oxidase
• The in vivo Effect of Sodium Fluoride on the Key Enzymes of Tryptophan Metabolism
• Roles of Active Oxygen and Superoxide Dismutase in Anthranilatnide Hydroxylation and its Derived Phenoxazinone-Like Pigment Formation by Rat Liver Microsomal Monooxygenase System
• Protective Effect of Tryptophan upon the Influence of N-Methylformamide on the Development, the NAD Synthesis, and the Activity of the Adenosine Diphosphate Ribosyl Transferase of Rat Embryos
• Induction of Tyrosine Aminotransferase by Tryptophan in Rat Liver
• TRYPTOPHAN METABOLISM IN INSECTS
• Tryptophan Metabolism in Drosophila
• Roles of Active Oxygen and Catalase in the Formation of Phenoxazinone Pigments Catalysed by Manganese Ion
• Ommochrome-Potassium Urate Complex as Pigment of Red Faeces of Locusta migratoria (Insecta, Orthoptera, Acrididae)
• Changes in Fluorescence and Size of the Cytoplasmic Granules in the Malpighian Tubules of Drosophila melanogaster Linked with Tryptophan Metabolism
• Hormonal Control of Pigmentation in Manduca sexta
• Tryptophan Metabolism and Morphological Color Change in Insects
• The Structure of Papiliochrome II, the Yellow Wing Pigment of the Papilionid Butterflies
• Some Chemical Properties of Papiliochrome R
• TRYPTOPHAN METABOLISM IN PLANTS AND MICROORGANISMS
• Metabolism of Tryptophan in Pseudomonas aureofaciens
• Does Tryptophan Side Chain Oxidase from Pseudomonas ATCC 29574 Contain a Quinoprotein?
• Tryptophan Side Chain Oxidase (TSO) - Structure and Reaction Mechanism
• Characterization of three Tryptophan Aminotransferases from Candida maltosa
• Anthranilate Hydroxylase and the Short-Cut-Pathway for the Biosynthesis of Nicotinamide Nucleotides in Aspergillus niger
• Biosynthesis of Tryptophan Derived Alkaloids in Higher Plants: Enzymati Formation of the Sarpagine-Ajmaline Group
• Acridone Alkaloid Biosynthesis in Tissue Cultures of Ruta graveolens
• Isolation and Biological Activities of Diterpene Anthraniloyl and 3-Hydroxyanthraniloyl Peptide Esters from Euphorbia mi Iii
• New Biological Significance of Indole-Containing Compounds as Initiators or Tumor Promoters in Chemical Carcinogenesis
• Biosynthesis of Serotonin and Auxin in Seeds of Juglans regia
• Blepharismone: a Conjugation-Inducing Tryptophan Derivative in the Ciliate Blepharisma
• Biological Activity of Blepharismone Derivatives - An Approach Towards Biogenesis of the Hormone
• TRYPTOPHAN IN PROTEINS AND PEPTIDES
• Advances in the Chemical Modification of Tryptophan in Peptides and Proteins
• Peptide Bond Cleavage at Tryptophan with Cyanogen Bromide - Mechanism of the Reaction
• Tryptophan, a Pitfall for the Peptide Chemist
• Photochemical arid Radiochemical Reactions of Tryptophan: Modification of a Single-Strand Binding Protein from Bacteriophage T4
• X-Ray Structure Analyses of Tryptophan Derivatives as Models for Stereochemical Aspects of the Toxic Peptides from Amanita Mushrooms
• AUTHOR INDEX
• SUBJECT INDEX
• ABBREVATIONS