The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep and wake, and its interaction with other wake-regulating systems. The orexin system is dissected at the cellular and molecular level to explore the diversity of the orexin-producing neurons, their projections, and their signaling pathways. Additionally, the book discusses the diseases which are associated with a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, and Alzheimer's disease, and explores the new potential therapeutic applications derived from the burst of research around this fascinating system. This publication is essential reading for neurobiologists, neurologists, psychopharmacologists, sleep researchers, and other researchers and clinical scientists interested in sleep, sleep research, insomnia, and medicine in general.

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Yes, you can access The Orexin System. Basic Science and Role in Sleep Pathology by Michel A. Steiner,Masashi Yanagisawa,Martine Clozel,M.A. Steiner,M. Yanagisawa,M. Clozel,Michel A., Steiner,Masashi, Yanagisawa,Martine, Clozel, Julien Bogousslavsky in PDF and/or ePUB format, as well as other popular books in Medicina & Neurologia. We have over one million books available in our catalogue for you to explore.

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Frontiers of Neurology andNeuroscience
The Orexin System.Basic Science and Rolein Sleep Pathology
Contents
Preface
Twenty-Three Years of Hypocretins: The “Rosetta Stone” of Sleep/Arousal Circuits
Interaction between Orexin Neurons and Monoaminergic Systems
Hypocretin/Orexin Receptor Pharmacology and Sleep Phases
Sleep, Orexin and Cognition
Subsecond Ensemble Dynamics of Orexin Neurons Link Sensation and Action
Heterogeneity of Hypocretin/Orexin Neurons
Sleep and Metabolism: Implication of Lateral Hypothalamic Neurons
Cellular Signaling Mechanisms of Hypocretin/Orexin
Sleep Problems in Narcolepsy and the Role of Hypocretin/Orexin Deficiency
The Insomnia-Addiction Positive Feedback Loop: Role of the Orexin System
Causes and Consequences of Chronic Sleep Deficiency and the Role of Orexin
Hypocretin/Orexin, Sleep and Alzheimer’s Disease
Author Index
Subject Index
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