Vitamin D

A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, USA, May 28–June 2, 1994

Anthony W. Norman, Roger Bouillon, Monique Thomasset, Anthony W. Norman, Roger Bouillon, Monique Thomasset

• Publisher: De Gruyter
• Year: 2020
• Print ISBN:
  9783110141573
• eBook ISBN:
  9783110882513
• Topic: Biological Sciences
• Subtopic: Biochemistry
• Index: Biological Sciences

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Table of contents

• FOREWORD
• Official Sponsors and Donors
• YOUNG INVESTIGATOR AWARDEES NINTH WORKSHOP ON VITAMIN D
• Vitamin D Workshop. Career Recognition Awardees
• Contents
• Chemistry of Vitamin D
• Shape and Conformation of Vitamin D. 11-Fluoro-1a-Hydroxyvitamin D₃: The Quest for Experimental Evidence of the Folded Vitamin D Conformation
• Conformation and Related Topological Features of Vitamin D: Structure-Function Relationships
• Chemical Conversion of Vitamin D₃ to Calcitriol Lactone
• Design, Synthesis, and SAR of Some 1-Substituted A-Ring Analogs of Calcitriol
• A General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from D-Pentoses
• Retiferols. Design and Synthesis of the New Class of Vitamin D Analogs
• Introduction of 1a-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions
• Synthesis and Determination of the Configurations of the 23-Hydroxylated Metabolites of Calcipotriol (MC 903) and their Epimers
• Syntheses of Potential Inhibitors of 25-Hydroxyvitamin D₃-1a-Hydroxylase: A-Ring Analogs
• Metallic Complexes of Hydroxylated Derivatives of Vitamin D₃
• A New Route to the Lythgoe-Roche's A-Ring Precursor of 1a,25-Dihydroxyvitamin D₃
• Structure-Activity Studies of Fluorinated Vitamin D Analogs
• An In Vitro Model of Previtamin D Photosynthesis as Possible Monitor of Ozone Depletion
• Synthesis of 24-Hydroxy-Vitamin D Analogues
• Chromatographic Isolation and Spectroscopic Characterization of the Photoisomers of 1a,25-Dihydroxy-Provitamin D₃
• A New Route to the Vitamin D Triene System
• Studies on the Synthesis of 19-Norprevitamin D₃ Analogues
• Structure/Function Studies of Vitamin D Steroids
• The Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications
• Future Prospects for Vitamin D Analogs
• Chemistry and Biology of 22,23-yne Analogs of Calcitriol
• Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity
• Activity of Vitamin D Analogs in Co-Transfected COS-7 Cells
• Synthesis and Biological Character of 1β-Hydroxylated Vitamin D₃ Analogs
• Biological Activity and Conformational Analysis of 1β,25-Dihydroxyvitamin D₃ and its Analogues
• Topological Mimics of the 6-s-cis-Conformer of 1a,25-Dihydroxyvitamin D₃ Based on the Provitamin D Skeleton
• Chemistry and Biology of Highly Active 22-oxy Analogs of 20-epi Calcitriol with Very Low Binding Affinity to the Vitamin D Recepto
• New Discoveries in Vitamin D Related Compounds
• Modelling of Previtamin D Photosynthesis in View of its Conformational Flexibility
• Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region
• Synthesis and Biological Activity of 23-oxa Vitamin D Analogues
• Synthesis and Biological Activity of 20-Hydroxylated Vitamin D Analogues
• 20-Methyl Vitamin D Analogues
• 2β-Substituted Calcitriols and Other A-Ring Substituted Analogues - Synthesis and Biological Results
• Syntheses and Biological Activity of 1ß-Substituted Active Vitamin D₃ Analogs
• Vitamin D Binding Protein
• Probing the Vitamin D-Sterol Binding Domain of Human Vitamin D-Binding Protein: Chemical Modification of Specific Amino Acid Residues
• Crystallization and Preliminary X-Ray Investigation of Vitamin D-Binding Protein from Human Serum
• Effects of Vitamin D-Binding Proteins on Biological Functions of 1 a,25-Dihydroxyvitamin D₃ Analogues
• Vitamin D Hydroxylases: Biochemistry and Regulation
• Differences of the Regulation of 24-Hydroxylase Gene Expression in the Kidney and Intestine
• Regulation of the Ferredoxin Component of Renal Hydroxylases at the Transcriptional and Postradiational Level and of the Protein Inhibitor of Cyclic AMP-Dependent Kinase
• Site and Rate of Hydroxylation of 1a-OH-D₃ Analogs by CYP27 Not Altered by Increasing Length or Changing Orientation of Vitamin D₃ Side Chain
• Protein Kinase C Up-Regulates 1 a,25-Dihydroxyvitamin D₃-Induced Expression of 24-Hydroxylase Gene
• IGF-I Restores the Age-Related Defect in Renal 1,25(OH)₂D₃ Biosynthesis in Response to Dietary Phosphorus Restriction in Rats
• In Vitro Production of 1,25-Dihydroxyvitamin D₃ by Cultured Mouse Kidney Cells and its Regulation by Extracellular Phosphate and IGF-1
• The Cytochromes P450 Catalyzing 25-Hydroxylation of Vitamin D and la-Hydroxy lation of 25-Hydroxyvitamin D₃ in Pig Liver
• Evidence that 1a - and 27-Hydroxylation of 25-Hydroxyvitamin D₃ are Catalyzed by CYP27 in Pig Kidney Mitochondria
• The Kinetics of Monocyte la-Hydroxy läse in Uremia. Modulation by Calcitriol and 25(OH)D₃ Therapy
• Eicosanoid Inhibitor and Cytokine Regulation of 1,25(OH)₂D₃ Synthesis in Synovial Fluid Macrophages from Patients with Inflammatory Arthritis
• 25-Hydroxyvitamin D-la-Hydroxy läse is Responsible for the Synthesis of 1.25-Dihydroxyvitamin D₃ by Peritoneal Macrophages of CAPD Treated Uremic Patients
• Influence of Extracellular Calcium in the Kinetic Behaviour of 1-Hydroxylase (1-OHase) and 24-Hydroxylase (24-OHase) in Walker Carcinosarcoma 256 Cells (WS) and in the Renal Proximal Tube Phenotype Cells (LLC-PK1)
• Insulin and Calcitonin Decrease the Expression of the Renal 25(OH)D-24- Hydroxylase Cytochrome P450 in Diabetic Rats
• Continuous Activation of 25-Hydroxyvitamin D₃-24-Hydroxylase mRNA Expression by 1a,25-Dihydroxyvitamin D₃-3ß-Bromoacetate
• Regulation of 24-Hydroxylase mRNA Expression by 1a,25(OH)₂D₃ and its Fluorinated Analogues
• Comparative Effects of 1,25-Dihydroxyvitamin D₃ and EB 1089 on Murine 25-Hydroxyvitamin D₃-24-Hydroxylase
• Vitamin D Metabolism and Catabolism
• Target Cell Metabolism of Vitamin D and its Analogs
• In Vivo Regulation of Rat Intestinal 24-Hydroxylase (I-24-OHase): Potential New Role of Calcitonin
• Metabolism of 1a,25-Dihydroxyvitamin D₃ and One of its A-Ring Diastereomer 1a,25-Dihydroxy-3-Epivitamin D₃ in Neonatal Human Keratinocytes
• Vitamin D Metabolism in Human Colon Adenocarcinoma-Derived Caco-2 Cells
• Studies on Vitamin D Metabolism by a Human Small Cell Lung Cancer (SCLC) Cell Line, NCI-H82
• The In Vitro Metabolism of Calcipotriol, 1,24(OH)₂D₃ and 1,25(OH)₂D₃
• Regulation of Tissue Inhibitor of Metalloproteinases (TIMP) by 1,25- and 24,25- Dihydroxyvitamin D₃ in the Rat Growth Plate
• The Effect of Parathyroid Hormone on Renal 24-Hydroxylase Activity in the Isolated Perfused Rat Kidney
• Steroidal Hormones as Modulators of Vitamin D Metabolism in Human Keratinocytes
• Potentialisation of Vitamin D (Analogs) by Cytochrome P-450 Enzyme Inhibitors is Analog- and Cell-type Specific
• Novel Cleavage of Vitamin D₂ Side Chain During Catabolism by Keratinocyte Cell Line
• 22-Oxacalcitriol is Metabolized to C₂₁ Side-Chain-Cleaved Products in Both Liver and Target Cells
• Metabolism of the 1a,25(OH)₂D₃ Analog 1a,25(OH)₂-16-ene-23-yne-D₃ in BALB/c Leukemic Mice and WEHI-3 Myeloid Leukemia Cells
• Microtubules Mediate Cellular 25(OH)D₃ Traffic and the Response to 1,25(OH)₂D₃ in Human Monocytes
• Study of the Metabolism of 1,25-Dihydroxy-16-ene-Vitamin D₃ in Rat Kidney Using On-line HPLC-Electrospray Tandem Mass Spectrometry
• Human Placental Explants: An Efficient In Vitro Model for Comparative Metabolism of 1,25(OH)₂D₃ and its Synthetic Analogs
• 24,25(OH)₂D₃ Modulates 1,25(OH)₂D₃ Metabolism in Human Osteoblasts
• Metabolism of 25 Hydroxy Vitamin D₃: Kinetics of 23 and 24 Hydroxylases in Human Term Placenta
• Comparative Study in Vitamin D Metabolism from the View-Point of Ontogeny and Phylogeny
• Receptors for 1a,25(OH)₂D₃
• Receptor Mediated Genomic Actions of 1,25(OH)₂D₃: Modulation by Phosphorylation
• Modulation of Vitamin D₃ Target Gene Selectivity by Receptor Dimerization
• The Molecular Basis for the Genomic Actions of the Vitamin D₃ Hormone
• Expression of RXRa in Human Leukemic Cells During Differentiation Induced by All-Trans Retinoic Acid and 1a,25-Dihydroxyvitamin D
• Differential Activation of the Vitamin D Receptor (VDR) by 1,25(OH)2- Vitamin D₃ and its 20-Epimers
• Dopamine Activates Vitamin D Receptor But Not Retinoid Receptor Mediated Transcription
• Ordered Binding of Human Vitamin D and Retinoid-X Receptor Complexes to Asymmetric Vitamin D-Responsive Elements
• Immunohistochemical Localization of 1,25-Dihydroxy vitamin D₃ [1,25(OH)₂D₃] Receptors (VDR) in Human and Rat Pancreas
• Structure-Function Relationship of Human Parathyroid Hormone on Vitamin D Receptor Regulation in Osteoblast-Like Cells (ROS 17/2.8)
• Insulin-Like Growth Factor I Up-Regulates Intestinal 1,25(OH)₂D₃ Receptor in Phosphorus Restricted Rats
• A Peptide C-Terminal to the Second Zn-Finger of Human Vitamin D Receptor is Able to Specify Nuclear Localization
• Molecular Cloning and Sequencing of a Novel cDNA Related to the Steroid/Thyroid/Vitamin Family of Nuclear Receptors from a Vitamin DDeficient Chick Intestinal cDNA Library
• Isolation and Analysis of cDNA Encoding a Naturally-Occurring Truncated Form of the Human Vitamin D Receptor
• EB 1089, a Vitamin D Analogue, Induces the Vitamin D Receptor to Form Selective Receptor Complexes Depending on Cell Type
• Gene Regulation
• 1,25(OH)₂D₃ Response Elements: Is There an Order?
• Vitamin D Regulation of Osteocalcin Gene Transcription: A Model for Defining Molecular Mechanisms of 1,25(OH)₂D₃ Control of Osteoblast Growth and Differentiation
• Regulation of Integrin Expression by 1,25 Dihydroxyvitamin D₃
• Identification of a Chicken Intestinal DNA Binding Activity Not Related to the Vitamin D Receptor, but Capable of Specific Binding to Vitamin D Response Elements
• Transcriptional Regulation of the Avian Mitochondrial Genome by Altered Dietary Vitamin D₃ Status: A Comparison of Intestinal and Kidney Responses
• A Novel Vitamin D Response Element in the Murine c-fos Promoter
• 1,25(OH)₂-Vitamin D3 (D3) Interactions with 3,5,3'-Triiodothyronine (T3) Signaling in 3 Osteosarcoma Cell Lines
• 1,25(OH)₂-Vitamin D₃ (D₃) Signaling in HT-29 Cells: Interactions with 9-eis Retinoic Acid (9-eis RA)
• Protein Inhibitor of Cyclic AMP-Dependent Protein Kinase: Genomic Cloning of a 1,25(OH)₂D₃ Down-Regulated Protein
• Lack of 9-eis Retinoic Acid Effect on Renal 24-Hydroxylase mRNA Expression by 1,25-Dihydroxyvitamin D₃ In Vivo
• Regulation of Osteopontin Expression by Calcitriol in Mouse Epidermal JB6 Cells
• Dissociation between Regulation of Growth and C-myc Oncogen Expression by Vitamin D in Caco-2 Cells
• TGF-ßl Inhibits the Induction of Osteocalcin Gene by 1,25(OH)₂D₃ at the Level of Transcription
• Mechanism of Action of 1,25-Dihydroxyvitamin D Differs in Kidney, Intestine, and Bone Cell Lines
• mRNA Levels of the Inhibitor Protein of cAMP-Dependent Protein Kinase are Regulated by 1,25(OH)₂D₃ and Forskolin
• Vitamin D Receptor (VDR) Interactions with Vitamin D₃ Response Elements (VDRE) in the Parathyroid Hormone (PTH) and Osteocalcin Genes are Different
• Coordinate Regulation of Rat Parathyroid Gland Function by Calcium and 1,25- Dihydroxyvitamin D₃
• Phosphorylation Pathways Affect Binding of AP-1 and Vitamin D Receptor to their Combined Response Element in the Promoter Region of Human Osteocalcin Gene
• Rapid Actions of Vitamin D Steroids
• Transmembrane Signal Pathways Induced by Calcitriol, Estradiol, Testosterone and Progesterone in Osteoblasts
• Non-Nuclear Actions of 1a,25(OH)₂D₃ and 24R,25(OH)₂D₃ in Mediating Intestinal Calcium Transport: The Use of Analogs to Study Membrane Receptors for Vitamin D Metabolites and to Determine Receptor Ligand Conformational Preferences
• Nongenomic Effects of Vitamin D
• Binding of the Occupied Vitamin D Receptor (VDR) to Extra-Nuclear Sites: A Potential Mechanism of Nongenomic Actions of 1a,25(OH)₂D₃
• A Common Mechanism for the Vitamin D Reeeptor Activation and for the Nongenomic Actions of Calcitriol
• The Calciotropic Hormone 1,25(OH)₂-Vitamin D₃ Stimulates Phospholipase D Activity in Cultured Muscle Cells
• Rapid Non-Genomic Effect of 1a,25-Dihydroxyvitamin D₃ on Osteoblast Nuclei
• 1a,25-Dìhydroxyvitamin D₃ Induces a Rapid and Sustained Increase in Cytosolic Calcium in Cultured Human Keratinocytes
• Aged-Related Changes in the Non-Genomic Response of Intestinal Mammalian Cells to 1,25-Dihydroxy-Vitamin D₃
• Video Imaging of Intracellular Calcium in Insulinoma Cells: Effects of 1,25(OH)₂D₃
• Cellular Signalling Responses Mediated by 1,25(OH)₂-Vitamin D₃ in Rat and Chick Myoblasts
• Involvement of Adenylate Cyclase System in 1,25-Dihydroxyvitamin D₃ Rapid Stimulation of Ca^{2 +} Uptake by Heart Cells
• Specific Binding of 1,25-Dihydroxyvitamin D₃ to Rat Colonocyte Basolateral Membranes
• Protein Kinase C Participates in the Signal Transduction Pathway Triggered by 1,25-Dihydroxyvitamin D₃ in Myocytes
• Calbindins D—Function and Gene Regulation: Calcium Transport
• Mechanistic Studies on Intestinal Ca^{2 +} Transport
• Vitamin D, the Intestinal Plasma Membrane Calcium Pump Gene Expression and the Calbindins
• Tissue Specific Calbindin-D_9K Gene Regulation by Calcitriol and Sexual Hormones
• Proteins that Bind to the Calbindin-D_9K Promoter: Known Factors and a New Intestinal Factor
• Studies of the Human Calbindin-D_9K Gene
• Calbindins Revisited in the Rat Dental Pulp
• In Situ Hybridization of Calbindins mRNAs in Rat Ameloblasts
• Immunoreactive Calbindins-D_28K and _9K Mineralization of Rat Epiphyseal Chondrocytes in Culture
• Regulation of Calbindin-D_28K by Parathyroid Hormone in MDBK Cells
• Phosphorylation and Modulation of Calbindin D_28K by Activation of Protein Kinase C (PKC)
• Caco-2 Cells: A Human Intestinal Cell Line for Studying the Biologic Activity of Vitamin D Analogs
• EGF Down Regulates Both Calbindin D_28K and the VDR in MDBK Cells
• Does Calbindin-D_28K Buffer Intracellular Free Calcium?
• Calbindin-D_28K (CaBP-D_28K) in the Rat Endocrine Pancreas: In Vivo and In Vitro Immunolocalization and its Regulation by Vitamin D₃ Deficiency and 1,25- Dihydroxyvitamin D₃
• Effect of Two Antiestrogens (Tamoxifen and ICI 182780) on Calbindin-D_9K Gene Expression In Vivo in the Rat Uterus, and In Vitro in Primary Cultures of Myometrial Cells
• Identification of a 9 kDa Calcium-Binding Protein in the Chick as Calbindin-D_9K
• Effect of Antisense Sequences Against Calretinin on WiDr Cells
• Intestinal Absorption of Calcium and Strontium Demonstrate a Similar Response to Calcitriol Treatment
• Physiological Concentrations of 24,25(OH)₂ Vitamin D₃ Decrease the Intestinal Calcium Uptake in the Atlantic Cod, Gadus Morhua
• Effects of Vitamin D and DL-Buthionine-S, R-Sulfoximine on Intestinal Calcium Absorption
• 1,25-(OH)₂D₃ Stimulates Ca²⁺ -Uptake Across the Duodenal Brush Border by at Least Two Independent Mechanisms
• Effect of Heavy Metals on the Level of Calbindin D^28K and the Assimilation of Ca in Chick Duodenum
• Apparent Nephron Localization of the 1,25(OH)₂D₃-Stimulated Calmodulin Binding Proteins in the Rat Kidney
• Raised Intestinal Calcium Secretion in the Young Oophorectomised Rat
• Validation of a Simple Test Measuring Intestinal Calcium Absorption Using Strontium as a Marker
• Cell Differentiation
• In Vitro Effects of Potent Vitamin D₃ Analogs on Proliferation and Differentiation of Seven Human Breast Cancer Cell Lines
• Terminal Differentiation of Human Leukemia Cells (HL60) by a Combination of 1,25-Dihydroxyvitamin D₃ and Retinoic Acid (All Trans or 9-Cis)
• 1,25-Dihydroxyvitamin D₃ Induces Growth of Thyroid C Cells and Inhibits Calcitonin Secretion In Vitro
• Differentiation of Human Myelomonocytic Leukemia Cell Lines by Retinoic Acid and Vitamin D₃ Analogs, MC903 and EB1089: Characterization of Cooperative Effects
• Effect of Ascorbate and Calcitriol on HL-60 Promyelocytic Cell Line Proliferation and Differentiation
• Evidence for a Vitamin D Paracrine System Regulating Fetal Pneumocyte Type II Maturation: Local Synthesis of 1,25-(OH)₂D₃ by Lung Fibroblasts
• Inhibition of IEC-6 Cell Growth by 1,25(OH)₂D₃: Involvement of TGFß
• Interactions between Vitamin D Derivatives, Retinoids and Granulocyte Macrophage - Colony Stimulating Factor in Leukemic Cell Differentiation
• 1,25(OH)₂D₃ and Agents that Increase Intracellular cAMP Synergistically Inhibit the Proliferation of Mouse Fibroblasts
• 1a,25-Dihydroxyvitamin D Rapidly Triggers Inhibition of Fibroblast Contraction of Collagen Lattices
• Cancer
• Immunology
• Dermatology
• Neurosciences
• Renal Osteodystrophy
• Bone and Cartilage
• Miscellaneous Biological Actions of Vitamin D Metabolites and Analogs
• Assays for Vitamin D Steroids
• Nutrition
• Osteoporosis
• Neonatology and Pregnancy
• Gerontology
• Other Basic Science Topics
• Other Clinical Topics
• Author Index
• Subject Index
• Cell Line Index
• Zoo Index