Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines

Strategies, Technologies, and Applications

Aihua Zhang, Wanying Wang

• Publisher: Wiley-VCH
• Year: 2021
• Print ISBN: 9783527349913
• eBook ISBN: 9783527835737
• Edition: 1
• Topic: Physical Sciences
• Subtopic: Spectroscopy & Spectrum Analysis

Highlights the importance and benefit of mass spectrometry-based metabolomics for identifying biomarkers that accurately screen for potential biomarkers of diseases

Mass spectrometry-based metabolomics offer new opportunities for biomarker discovery in complex diseases and may provide pathological understanding of diseases beyond traditional technologies. It is the systematic analysis of low-molecular-weight metabolites in biological samples and has been applied to discovering and identifying the perturbed pathways. Currently, mass spectrometry-based metabolomics has become an important tool in clinical research and the diagnosis of human disease.

Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines comprehensively presents the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics such as metabolites analysis, biomarker discovery, technical challenges, discovery of natural product, mechanism interpretation of action, discovery of active ingredients, clinical application and precision medicine, and enhancing their biomedical value in a real world of biomedicine, shedding light on the potential for spectrometry-based metabolomics. It highlights the value of mass spectrometry-based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, especially, to link phytochemical analysis with the assessment of pharmacological effect and therapeutic potential. Each chapter has been laid out with introduction, method, up-to-date literature, identification of biomarker, and applications

• Covers the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics in the discovery of biomarker, active ingredients, natural product, etc.
• Constitutes a unique and indispensable practical guide for any phytochemistry or related laboratory, and provides hands-on description of new techniques
• Provides a guide for new practitioners of pharmacologists, pharmacological scholars, drug developers, botanist, researchers of traditional medicines.

Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines provides a landmark of mass spectrometry-based metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all biomedical science fields.

Table of contents

• Cover
• Title Page
• Copyright
• Contents
• Preface
• Chapter 1 Current State of the Art of High‐Throughput Metabolomics
• Chapter 2 Innovations in Analytical Techniques of Metabolomics
• Chapter 3 Sample Preparation Method for Mass Spectrometry‐Based Metabolomics
• Chapter 4 Multivariate Data Analysis Approach for Mass Spectrometry‐Based Metabolomics
• Chapter 5 Mass Spectrometry‐Driven Metabolomics for Metabolites and Metabolic Pathway Analysis
• Chapter 6 Metabolomics as Drivers for Biomarker Discovery and Mechanism Interpretation
• Chapter 7 Current Status of Technical Challenges in Mass Spectrometry‐Driven Metabolomics
• Chapter 8 The Application of Metabolomics in Cancer Management
• Chapter 9 Metabolomics in Coronary Heart Disease: From Biomarker Identification to Pathomechanism Insights
• Chapter 10 Metabolomics Applications in Neurological Disease
• Chapter 11 Metabolomics Toward Precision Medicine
• Chapter 12 Mass Spectrometry‐Based Metabolomics Toward Biological Function Analysis
• Chapter 13 Mass Spectrometry‐Driven Active Ingredients Discovery from Herbal Medicine
• Chapter 14 Metabolomics Application in Herbal Medicine
• Chapter 15 Mass Spectrometry‐Based Metabolomics Insights into the Mode of Action of Natural Products
• Chapter 16 Mass Spectrometry‐Driven Lipidomics for Biomarker, Molecular Mechanism, and Therapy
• Chapter 17 Potential Application of Mass Spectrometry‐Based Lipidomics for Herbal Medicine
• Index
• EULA