The Medicinal Chemist's Guide to Solving ADMET Challenges summarizes a series of design strategies and tactics that have been successfully employed across pharmaceutical and academic laboratories to solve common ADMET issues. These are exemplified with a curated collection of concrete examples displayed in a highly visual "table-of-contents" style format, allowing readers to rapidly identify the most promising approaches applicable to their own challenges. Each ADMET parameter is introduced in a concise yet comprehensive manner and includes background, relevance and screening strategies. Medicinal chemistry knowledge of how best to modify molecular structure to solve ADMET issues is challenging to retrieve from the literature, public databases and even corporate data warehouses. The Medicinal Chemist's Guide to Solving ADMET Challenges addresses this gap by presenting state-of-the-art design strategies put together by a global group of experienced medicinal chemists and ADMET experts across academia and the pharmaceutical industry.
- 518 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
eBook - ePub
The Medicinal Chemist's Guide to Solving ADMET Challenges
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Table of contents
- Cover
- Half Title
- Drug Discovery Series
- Title
- Copyright
- Preface
- Contents
- Chapter 1 Overview of Strategies for Solving ADMET Challenges
- Chapter 2 Tactics to Improve Solubility
- Chapter 3 Optimisation of Passive Permeability for Oral Absorption
- Chapter 4 Targeting Gastrointestinal Uptake Transporters
- Chapter 5 Drug Efflux Transporters: P-gp and BCRP
- Chapter 6 OATs and OCTs: The SLC22 Family of Organic Anion and Cation Transporters
- Chapter 7 OATPs: The SLCO Family of Organic Anion Transporting Polypeptide Transporters
- Chapter 8 Bile Salt Export Pump (BSEP) Inhibition
- Chapter 9 Cytochrome P450 Metabolism
- Chapter 10 Cytochrome P450 Induction
- Chapter 11 Strategies to Mitigate CYP450 Inhibition
- Chapter 12 Aldehyde and Xanthine Oxidase Metabolism
- Chapter 13 Glucuronidation
- Chapter 14 Sulfation
- Chapter 15 Reactive Metabolites
- Chapter 16 Genotoxicity
- Chapter 17 Drug-induced Photosensitivity
- Chapter 18 Drug-induced Phospholipidosis
- Chapter 19 Cardiac Ion Channel Inhibition
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Yes, you can access The Medicinal Chemist's Guide to Solving ADMET Challenges by Patrick Schnider in PDF and/or ePUB format, as well as other popular books in Physical Sciences & Biochemistry. We have over 1.5 million books available in our catalogue for you to explore.