The Medicinal Chemist's Guide to Solving ADMET Challenges
eBook - ePub

The Medicinal Chemist's Guide to Solving ADMET Challenges

  1. 518 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

The Medicinal Chemist's Guide to Solving ADMET Challenges

About this book

The Medicinal Chemist's Guide to Solving ADMET Challenges summarizes a series of design strategies and tactics that have been successfully employed across pharmaceutical and academic laboratories to solve common ADMET issues. These are exemplified with a curated collection of concrete examples displayed in a highly visual "table-of-contents" style format, allowing readers to rapidly identify the most promising approaches applicable to their own challenges. Each ADMET parameter is introduced in a concise yet comprehensive manner and includes background, relevance and screening strategies. Medicinal chemistry knowledge of how best to modify molecular structure to solve ADMET issues is challenging to retrieve from the literature, public databases and even corporate data warehouses. The Medicinal Chemist's Guide to Solving ADMET Challenges addresses this gap by presenting state-of-the-art design strategies put together by a global group of experienced medicinal chemists and ADMET experts across academia and the pharmaceutical industry.

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Yes, you can access The Medicinal Chemist's Guide to Solving ADMET Challenges by Patrick Schnider in PDF and/or ePUB format, as well as other popular books in Physical Sciences & Biochemistry. We have over one million books available in our catalogue for you to explore.

Information

Publisher
Royal Society of Chemistry
Year
2021
Print ISBN
9781788012270
eBook ISBN
9781839160493
Edition
1
Topic
Physical Sciences
Subtopic
Biochemistry

Table of contents

  1. Cover
  2. Half Title
  3. Drug Discovery Series
  4. Title
  5. Copyright
  6. Preface
  7. Contents
  8. Chapter 1 Overview of Strategies for Solving ADMET Challenges
  9. Chapter 2 Tactics to Improve Solubility
  10. Chapter 3 Optimisation of Passive Permeability for Oral Absorption
  11. Chapter 4 Targeting Gastrointestinal Uptake Transporters
  12. Chapter 5 Drug Efflux Transporters: P-gp and BCRP
  13. Chapter 6 OATs and OCTs: The SLC22 Family of Organic Anion and Cation Transporters
  14. Chapter 7 OATPs: The SLCO Family of Organic Anion Transporting Polypeptide Transporters
  15. Chapter 8 Bile Salt Export Pump (BSEP) Inhibition
  16. Chapter 9 Cytochrome P450 Metabolism
  17. Chapter 10 Cytochrome P450 Induction
  18. Chapter 11 Strategies to Mitigate CYP450 Inhibition
  19. Chapter 12 Aldehyde and Xanthine Oxidase Metabolism
  20. Chapter 13 Glucuronidation
  21. Chapter 14 Sulfation
  22. Chapter 15 Reactive Metabolites
  23. Chapter 16 Genotoxicity
  24. Chapter 17 Drug-induced Photosensitivity
  25. Chapter 18 Drug-induced Phospholipidosis
  26. Chapter 19 Cardiac Ion Channel Inhibition