Entwicklung einer variationsfähigen Synthese für das Antibiotikum (+)-Thiolactomycin und für verwandte Thiotetronsäuren
eBook - PDF

Entwicklung einer variationsfähigen Synthese für das Antibiotikum (+)-Thiolactomycin und für verwandte Thiotetronsäuren

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  1. 386 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Entwicklung einer variationsfähigen Synthese für das Antibiotikum (+)-Thiolactomycin und für verwandte Thiotetronsäuren

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About this book

Thiolactomycin, ein Thiotetronsäure-Naturstoff, der vom Aktinomycetenstamm Nocardia sp. produziert wird, stellt ein interessantes Syntheseziel dar. Zum einen seiner Wirkung halber, da Thiolactomycin Wirkung gegenüber Mycobacterium tuberculosis sowie dem Malaria-Erreger Plasmodium falciparum zeigt. Dabei beeinflusst Thiolactomycin die bakterielle, aber deutlich weniger die menschliche Fettsäuresynthese. Zum anderen seiner Struktur halber, da Thiolactomycin neben seiner Thiotetronsäure-Einheit mit dem quartären Schwefel-haltigen Stereozentrum sowie der Dien-Kette interessante Strukturelemente beinhaltet. Die Schlüsselschritte der hier beschriebenen Synthese sind die katalytische asymmetrische Sharpless Epoxidierung von 2, 4-Pentadien-1-olen sowie eine speziell entwickelte syn-selektive SN'-Thiolyse der resultierenden allylischen Epoxide.

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Yes, you can access Entwicklung einer variationsfähigen Synthese für das Antibiotikum (+)-Thiolactomycin und für verwandte Thiotetronsäuren by in PDF and/or ePUB format. We have over one million books available in our catalogue for you to explore.

Information

Publisher
Cuvillier Verlag
Year
2007
Print ISBN
9783867272919
eBook ISBN
9783736922914
Edition
1

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