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Allosteric Interactions in P2X Receptor Subunits
Allosteric Interactions in P2X Receptor Subunits
📖 eBook - PDF

Allosteric Interactions in P2X Receptor Subunits

Photolabeling and Fluorescence Technologies to study P2X receptors

Yogesh Bhargava

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📖 eBook - PDF

Allosteric Interactions in P2X Receptor Subunits

Photolabeling and Fluorescence Technologies to study P2X receptors

Yogesh Bhargava

About This Book

P2X receptors represent the third superfamily of ligand gated ion channels with ATP as their natural ligand. In spite of them being an attractive drug target, their potential as a drug target is limited by the lack of basic understanding of the structure-function relationship of these receptors. In this work, I have investigated the behaviour of homomeric P2X receptor subunits with the help of photolabeling and fluorescence techniques coupled with electrophysiological measurements using Xenopus laevis oocytes heterologous expression system. Photolabeling system offered real time labelling of P2X receptors and concurrent measurement of current from the same set of receptors. Also, this study for the first time describes the agonist potency of Alexa-ATP (a fluorescent ATP analogue) on P2X1 receptors. Using these technologies, it was found that the receptor subunits are not independent but interacting with each other in a cooperative manner. This work has attempted to answer few intriguing questions in the field of P2X receptor research and I think that the answers provide many avenues to the basic understanding of the functioning of P2X receptors.

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Citation styles for Allosteric Interactions in P2X Receptor SubunitsHow to cite Allosteric Interactions in P2X Receptor Subunits for your reference list or bibliography: select your referencing style from the list below and hit 'copy' to generate a citation. If your style isn't in the list, you can start a free trial to access over 20 additional styles from the Perlego eReader.
APA 6 Citation
Bhargava, Y. (2017). Allosteric Interactions in P2X Receptor Subunits (1st ed.). LAP LAMBERT Academic Publishing. Retrieved from https://www.perlego.com/book/3414451/allosteric-interactions-in-p2x-receptor-subunits-photolabeling-and-fluorescence-technologies-to-study-p2x-receptors-pdf (Original work published 2017)
Chicago Citation
Bhargava, Yogesh. (2017) 2017. Allosteric Interactions in P2X Receptor Subunits. 1st ed. LAP LAMBERT Academic Publishing. https://www.perlego.com/book/3414451/allosteric-interactions-in-p2x-receptor-subunits-photolabeling-and-fluorescence-technologies-to-study-p2x-receptors-pdf.
Harvard Citation
Bhargava, Y. (2017) Allosteric Interactions in P2X Receptor Subunits. 1st edn. LAP LAMBERT Academic Publishing. Available at: https://www.perlego.com/book/3414451/allosteric-interactions-in-p2x-receptor-subunits-photolabeling-and-fluorescence-technologies-to-study-p2x-receptors-pdf (Accessed: 15 October 2022).
MLA 7 Citation
Bhargava, Yogesh. Allosteric Interactions in P2X Receptor Subunits. 1st ed. LAP LAMBERT Academic Publishing, 2017. Web. 15 Oct. 2022.