In this book, the effect of nanofluids as the coolant on solid and annular fuels for a typical VVER-1000 core is analysed. The considered nanofluids are various mixture composed of water and particles of Al2O3, TiO2, and CuO. By using the nanofluids, the central fuel temperature is reduced and the temperature of the coolant is increased. In addition, by increasing the heated surfaces in annular fuel, the heat flux on these surfaces is reduced, the minimum departure from nucleate boiling ratio (MDNBR) margin is increased, and therefore the critical heat flux can be increased. Finally, it is concluded the use of the annular fuel instead of solid fuel and also the use of the nanofluids as coolant in the core of the reactor, thus security and efficiency of the nuclear power plant will be increased.