The book Surface Energetics of HIV interactions with drug - treated blood is a novel research work geared towards understanding the role of energy of interactions in HIV-infected blood cells (lymphocytes) systems. The surface energetics of the interactions was mathematically described using the Lifshitz theory with the concept of surface free energy and actual measurements obtained using a UV-Spectrophotometer. The spectrophotometric data collected were used in conjunction with Lifshitz formula to obtain an expression for Hamaker coefficient of the interaction process. Negative absolute combined Hamaker coefficient for each of the five antiretroviral drugs interacting with infected blood implies net negative van der Waals forces indicating a possible repulsion or blocking of the invading virus by the administered antiretroviral drugs. The coating effectiveness of antiretroviral drugs was calculated and the results obtained were used for comparative studies. Antiretroviral drugs increased the surface free energy of blood cells. A thermodynamic criterion for HIV-drug interaction prediction was suggested and found to be a valuable tool in HIV study. This may be useful in drug design.