Taxonomic study of angiosperm flora at Katakhali Pouroshova of Rajshahi district, Bangladesh was carried out from July 2013 to April 2015. A total of 163 species belonging to 143 genera under 66 families were recorded. One hundred and forty three (143) medicinal plants have been documented with their uses for the cure of more than 109 diseases, and some of these are abscess, asthma, abortion, cough, cold, chicken pox, constipation, dysentery, diarrhea, diabetes, eczema, fever, and fracture of bone, headache, heart disease, itches, jaundice, menstrual disease, paralysis, piles, skin diseases, snake-bite, sex problems, toothache, vomiting, worm, wound and others. In majority cases, leaves of the medicinal plants were found leading in terms of their use followed by whole plant, stem, bark, fruits, rhizome, seed, root and flower. For each species scientific name, family, medicinal use and part(s) used are provided.