Gutta-percha has been the standard obturation material used in root canal therapy since its introduction in 1914 by Callahan. The aim of this study was to compare the sealing ability of two obturating material by using different obturation techniques, cold lateral condensation technique, carrier based thermafill technique, and Resilon and epiphany sealer using lateral condensation technique. Fifty one single rooted extracted human teeth were selected and randomly divided into three groups, containing 15 in each group, setting aside six teeth as positive and negative control groups. They were obturated with gutta percha and adseal sealer using cold lateral condensation and carrier based thermafill with adseal sealer and with Resilon and epiphany sealer using lateral condensation technique. The apical leakage was measured using dye penetration methodology. The teeth filled with Gutta percha and Adseal using cold lateral compaction technique showed the least apical leakage, while the most apical leakage was displayed by Resilon. Based on the data of this study, all groups produced a satisfactory seal. However, Resilon and Epiphany sealer showed the most apical leakage.