Drug Transporters

Molecular Characterization and Role in Drug Disposition

Guofeng You, Marilyn E. Morris, Guofeng You, Marilyn E. Morris, Binghe Wang

• Publisher: Wiley
• Year: 2022
• Print ISBN: 9781119737551
• eBook ISBN: 9781119739876
• Edition: 3
• Topic: Medicine
• Subtopic: Pharmacology

DRUG TRANSPORTERS

Drug transporter fundamentals and relevant principles and techniques, featuring new and expanded chapters

Drug Transporters: Molecular Characterization and Role in Drug Disposition provides in-depth analysis of the conceptual evolution and technical development for studying drug transporters. Contributions by an international panel of leading researchers address advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. Divided into two parts, the book first provides a thorough overview of relevant drug transporters before detailing the principles of drug transport and associated techniques.

The updated and expanded third edition includes new chapters on in vitro-in vivo scale-up of drug transport activities, the ontogeny of drug transporters, the application of physiologically-based pharmacokinetic and pharmacodynamic modeling, and the use of transporters as therapeutic targets for diseases.

• Reflects the current state of the field and offers perspectives on future directions
• Covers basic knowledge, clinical outcomes, and emerging discoveries in transporter science
• Provides up-to-date information on drug transporter families, mechanisms, and clinical implications
• Includes extensive references and numerous figures and tables throughout

Understandable for novices while offering sufficient depth for more experienced researchers, Drug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition is an excellent textbook for pharmacological or physiological science courses in drug/membrane transport, and an invaluable reference for academic or industrial scientists working in the transporter field and related areas of drug metabolism, pharmacokinetics, and pharmacodynamics.

INDEX

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• ABCB1, 199, 259, 362–364, 380–382
• ABCB4, 199, 259
• ABCB11, 192–193, 259
• ABCC1, 225, 260
• ABCC2, 224, 225, 259
• ABCC3, 225, 260
• ABCC4, 225–226, 260
• ABCC5, 226, 260
• ABCC6, 224, 226, 260
• ABCC10, 226
• ABCC11, 224–226
• ABCC/MRP proteins
  • drug resistance profiles of, 221–223
  • drug transporter, 217, 223
  • efflux transporters, 217
  • expression and localization of, 215, 217–221
  • genetic variants, 213, 214, 223–226
  • human cancer, 215, 217–221
  • interindividual variability of, 215, 217
  • molecular characterization, 215
  • nomenclature, 215
  • substrate specificity of, 221–223
  • susceptibility to complex disease, 225–226
  • topology of, 216
• ABCCs, 366
• ABCG2, 259, 364–366, 382see also breast cancer resistance protein (BCRP)
  • cancer, 244–246
  • discovery and nomenclature, 235
  • drug resistance, 244–246
  • expression, 236–237, 242–244
  • gene, 236
  • genetic polymorphisms, 246–248
  • Jr(a) phenotype, 242
  • structural characterization of, 239
  • substrates and inhibitors of, 242
  • urate and gout, 241–242
• ABCP gene, 235
• ABC transporters see ATP‐binding cassette (ABC) transporters
• abiraterone, 100
• absorption, distribution, clearance, and elimination (ADCE), 444, 445
• absorption, distribution...

Table of contents

• Cover
• Table of Contents
• Series Page
• Title Page
• Copyright Page
• Dedication Page
• LIST OF CONTRIBUTORS
• PREFACE
• 1OVERVIEW OF DRUG TRANSPORTER FAMILIES
• 2ORGANIC CATION AND ZWITTERION TRANSPORTERS
• 3MULTIDRUG AND TOXIN EXTRUSION PROTEINS
• 4ORGANIC ANION TRANSPORTERS (OATs)
• 5ORGANIC ANION TRANSPORTING POLYPEPTIDES OATP
• 6MAMMALIAN OLIGOPEPTIDE TRANSPORTERS
• 7MONOCARBOXYLIC ACID TRANSPORTERS
• 8 THE NUCLEOSIDE TRANSPORTERS CNTs AND ENTs
• 9BILE ACID TRANSPORTERS
• 10THE P‐GLYCOPROTEIN MULTIDRUG TRANSPORTER
• 11MULTIDRUG RESISTANCE PROTEINS OF THE ABCC SUBFAMILY
• 12ABCG2, THE BREAST CANCER RESISTANCE PROTEIN (BCRP)
• 13DRUG TRANSPORT IN THE LIVER
• 14DRUG TRANSPORT IN THE BRAIN
• 15DRUG TRANSPORT IN THE KIDNEY
• 16DRUG TRANSPORTERS IN THE HUMAN INTESTINE
• 17DRUG TRANSPORT IN THE PLACENTA
• 18POLYMORPHISMS OF DRUG TRANSPORTERS AND CLINICAL RELEVANCE
• 19ONTOGENY OF DRUG TRANSPORTERS
• 20EXPERIMENTAL APPROACHES FOR STUDYING DRUG TRANSPORTERS
• 21TRANSPORTERS‐MEDIATED DRUG DISPOSITION—PHYSIOCHEMISTRY AND IN SILICO APPROACHES
• 22IN VITRO–IN VIVOSCALE‐UP OF DRUG TRANSPORT ACTIVITIES
• 23 APPLICATION OF PHYSIOLOGICALLY BASED PHARMACOKINETIC AND PHARMACODYNAMIC (PBPK/PD) MODELING COMPRISING TRANSPORTERS
• 24TRANSPORTERS AS THERAPEUTIC TARGETS IN HUMAN DISEASES
• 25DIET/NUTRIENT INTERACTIONS WITH DRUG TRANSPORTERS
• INDEX
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