Evidence-Based Research in Ayurveda Against COVID-19 in Compliance with Standardized Protocols and Practices
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Evidence-Based Research in Ayurveda Against COVID-19 in Compliance with Standardized Protocols and Practices

Acharya Balkrishna

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eBook - ePub

Evidence-Based Research in Ayurveda Against COVID-19 in Compliance with Standardized Protocols and Practices

Acharya Balkrishna

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About This Book

This book details all the intricacies and essential knowledge involved in the research and development of the Coronil Kit – a combination of 3 ayurvedic medications for the common cold. It informs the reader about the huge potential of herbal drugs in fighting against any type of disease through evidence-based data of clinical trials and experiments. The book demonstrates how current scientific techniques can be applied to understand healing capacities of plants at their molecular level and thus utilizing their different natural product combinations to treat diseases by targeting harmful micro-organisms and simultaneously boosting the immune system. It covers methods of virtual screening and computational validation of identified phytochemicals as potential antiviral agents against the SARS-CoV-2 virus. Key features: 1. Covers the molecular etiology of COVID-19 virus, 2. Covers guidance on drug formulation, hazard assessment and clinical trials based on approved methods by regulatory organizations 3. Covers pharmacological, toxicological and technically verified chemical composition of medicinal plants 4. Includes information about in vivo experiments and analysis of Humanoid Zebrafish trials 5. Includes methods of identifying antiviral agents against SARS-CoV-2 virus 6. Includes chemical, analytical and technical studies of Coronil 7. Includes 70 informative colored figures over 7 chapters 8. Includes a bibliography and appendix The book is primarily intended as a primary resource for medical research scholars and researchers in pharmaceutical companies and as a secondary resource for B.A.M.S. students, medical postgraduate students and ayurveda enthusiasts.

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Information

Publisher
Bentham Science Publishers
Year
2001
ISBN
9789815051186
Topic
Medicine
Subtopic
Pharmacology

Formulation, Licensing, Chemical Characterization, and Validation of Ayurvedic Medicine



Acharya Balkrishna

Abstract

This chapter, besides sharing the story behind the formulation and development of Ayurvedic medications acceptable in modern medicine, provides a detailed standard operating procedure for developing Ayurvedic drugs. To fight the COVID-19 infection, caused by the SARS-CoV-2 coronavirus, Patanjali Research Institute (PRI), Haridwar, developed the Divya Swasari Coronil kit. It contains Coronil Tablet, Divya Swasari Vati, and Divya Anu Taila. Divya Pharmacy, Haridwar, India, has obtained a manufacturing license from the Ayurvedic & Unani Department of Uttarakhand, Dehradun (License No.: 13-71-72/D-431/2020-2021) for Coronil and Swasari Vati tablets. Divya Coronil tablet has been formulated from a blend of Giloy, Ashwagandha, and Tulsi, whereas Divya Swasari Vati and Divya Anu Taila were prepared according to the classical recipe mentioned in traditional Ayurvedic texts. Analytical methods have been developed to identify and quantify the active phytoconstituents present in these blends and tablets. Sophisticated techniques are used in the manufacturing of these tablets, like liquid chromatography, equipped with single quadrupole, colloisan cell and time of light (UPLC/QToF MS), high-performance liquid chromatography (HPLC) equipped with PDA detector and high-performance thin layer chromatography (HPTLC) with automatic spotting, in which developing and scanning chambers are used for the identification and quantification of herbs. The methods have been validated in-house using ICH-Q2 (R1) and pharmacopoeia guidelines to demonstrate the repeatability, reproducibility, and reliability of the data generated. There are stringent quality checks for the authentication of raw material used in the manufacturing of the tablet, along with in-process checks and the final release of the batch. The ...

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