Principles in Microbiome Engineering

Matthew W. Chang, Sang Yup Lee, Jens Nielsen, Gregory Stephanopoulos

• Publisher: Wiley-VCH
• Year: 2022
• Print ISBN: 9783527347254
• eBook ISBN: 9783527825486
• Edition: 1
• Topic: Scienze biologiche
• Subtopic: Biotecnologia

Principles in Microbiome Engineering

Provides an overview of the techniques and applications insight into the complex composition and interactions of microbiomes

Microbiomes, the communities of microorganisms that inhabit specific ecosystems or organisms, can be engineered to modify the structure of microbiota and reestablish ecological balance. In recent years, a better understanding of microbial composition and host-microbe interactions has led to the development of new applications for improving human health and increasing agricultural productivity and quality.

Principles in Microbiome Engineering introduces readers to the tools and applications involved in manipulating the composition of a microbial community to improve the function of an eco-system. Covering a range of key topics, this up-to-date volume discusses current research in areas such as microbiome-based therapeutics for human diseases, crop plant breeding, animal husbandry, soil engineering, food and beverage applications, and more. Divided into three sections, the text first describes the critical roles of systems biology, synthetic biology, computer modelling, and machine learning in microbiome engineering. Next, the volume explores various state-of-the-art applications, including cancer immunotherapy and prevention of diseases associated with the human microbiome, followed by a concluding section offering perspectives on the future of microbiome engineering and potential applications.

• Introduces a variety of applications of microbiome engineering in the fields of medicine, agriculture, and food and beverage products
• Presents current research into the complex interactions and relationships between microbiomes and biotic and abiotic elements of their environments
• Examines the use of technologies such as Artificial Intelligence (AI), Machine Learning (ML), and Big Data analytics to advance understanding of microbiomes
• Discusses the engineering of microbiomes to address human health conditions such as neuro psychiatric disorders and autoimmune and inflammatory diseases

Edited and authored by leading researchers in the rapidly evolving field, Principles in Microbiome Engineering is an essential resource for biotechnologists, biochemists, microbiologists, pharmacologists, and practitioners working in the biotechnology and pharmaceutical industries.

Table of contents

• Cover
• Table of Contents
• Title Page
• Copyright
• Preface
• 1 Diet‐Based Microbiome Modulation: You are What You Eat
• 2 Microbiome Engineering for Metabolic Disorders
• 3 Repurposing Microbes for Therapeutic Applications in Humans
• 4 Modulating Residence Time and Biogeography of Engineered Probiotics
• 5 Microbiome Engineering for Next‐Generation Precision Agriculture
• 6 Biological Sensors for Microbiome Diagnostics
• 7 Principles, Tools, and Applications of Synthetic Consortia Toward Microbiome Engineering
• 8 Fecal Microbiota Transplantation for Microbiome Modulation: A Clinical View
• 9 Maternal Microbiota as a Therapeutic Target
• 10 Transcription Factor‐Based Biosensors and Their Application in Microbiome Engineering
• Index
• Wiley End User License Agreement