Transition Metal-Catalyzed Carbene Transformations

Jianbo Wang, Chi-Ming Che, Michael P. Doyle, Jianbo Wang, Chi-Ming Che, Michael P. Doyle

• Publisher: Wiley-VCH
• Year: 2021
• Print ISBN: 9783527347995
• eBook ISBN: 9783527829156
• Edition: 1
• Topic: Physical Sciences
• Subtopic: Organic Chemistry

Presents an up-to-date overview of the rapidly growing field of carbene transformations

Carbene transformations have had an enormous impact on catalysis and organometallic chemistry. With the growth of transition metal-catalyzed carbene transformations in recent decades, carbene transformations are today an important compound class in organic synthesis as well as in the pharmaceutical and agrochemical industries. Edited by leading experts in the field, Transition Metal-Catalyzed Carbene Transformations is a thorough summary of the most recent advances in the rapidly expanding research area.

This authoritative volume covers different reaction types such as ring forming reactions and rearrangement reactions, details their conditions and properties, and provides readers with accurate information on a wide range of carbene reactions. Twelve in-depth chapters address topics including carbene C-H bond insertion in alkane functionalization, the application of engineered enzymes in asymmetric carbene transfer, progress in transition-metal-catalyzed cross-coupling using carbene precursors, and more. Throughout the text, the authors highlight novel catalytic systems, transformations, and applications of transition-metal-catalyzed carbene transfer.

• Highlights the dynamic nature of the field of transition-metal-catalyzed carbene transformations
• Summarizes the catalytic radical approach for selective carbene cyclopropanation, high enantioselectivity in X-H insertions, and bio-inspired carbene transformations
• Introduces chiral N,N'-dioxide and chiral guanidine-based catalysts and different transformations with gold catalysis
• Discusses approaches in cycloaddition reactions with metal carbenes and polymerization with carbene transformations
• Outlines multicomponent reactions through gem-difunctionalization and transition-metal-catalyzed cross-coupling using carbene precursors

Transition Metal-Catalyzed Carbene Transformations is essential reading for all chemists involved in organometallics, including organic and inorganic chemists, catalytic chemists, and chemists working in industry.

Table of contents

• Cover
• Table of Contents
• Title Page
• Copyright
• Preface
• 1 Alkane Functionalization by Metal‐Catalyzed Carbene Insertion from Diazo Reagents
• 2 Catalytic Radical Approach for Selective Carbene Transfers via Cobalt(II)‐Based Metalloradical Catalysis
• 3 Catalytic Enantioselective Carbene Insertions into Heteroatom–Hydrogen Bonds
• 4 Engineering Enzymes for New‐to‐Nature Carbene Chemistry
• 5 Metal Carbene Cycloaddition Reactions
• 6 Metal‐Catalyzed Decarbenations by Retro‐Cyclopropanation
• 7 Gold‐Catalyzed Oxidation of Alkynes by N‐Oxides or Sulfoxides
• 8 Transition‐Metal‐Catalyzed Carbene Transformations for Polymer Syntheses
• 9 Metal‐Catalyzed Quinoid Carbene (QC) Transfer Reactions
• 10 Asymmetric Rearrangement and Insertion Reactions with Metal–Carbenoids Promoted by Chiral N,N′‐Dioxide or Guanidine‐Based Catalysts
• 11 Multi‐Component Reaction via gem‐Difunctionalization of Metal Carbene
• 12 Transition‐Metal‐Catalyzed Cross‐Coupling with Carbene Precursors
• Index
• End User License Agreement