Modern Avenues in Metal-Nucleic Acid Chemistry

Jens Müller, Bernhard Lippert, Jens Müller, Bernhard Lippert

• Publisher: CRC Press
• Year: 2023
• Print ISBN: 9781032218175
• eBook ISBN: 9781000847918
• Edition: 1
• Topic: Medicine
• Subtopic: Pharmacology

Volume 25, entitled Modern Avenues in Metal-Nucleic Acid Chemistry, of the series Metal Ions in Life Sciences (MILS), provides a timely overview of selected relevant developments in a field which previously had a pronounced focus on fundamental chemistry aspects such as coordination principles, structural chemistry, and consequences for biological processes and disease-related medicinal issues. More recently, also as a consequence of the advent of supramolecular chemistry, advancements in nanochemistry, and new bio-analytical methods, novel aspects of this field have emerged. MILS-25 gives a state-of-the-art account on the present state of research in this field, addressing, among others, porous materials, non-covalent interactions, stimuli-responsive bioconjugates, DNA-templated metal arrays and nanoclusters, genotyping, guanine quadruplexes, and riboswitches. It consists of 15 comprehensive chapters with over 1600 citations, 160 figures ( 90 of them in color), with key contributions from 40 international experts from Europe, Asia, and America. It is an essential resource for scientists from numerous disciplines, ranging from materials science to biochemistry, by way of classical chemistry and physics.

• It offers an update on nucleic acid – metal complex bioconjugates and their applications
• It provides an insight into coordination polymers involving nucleic acid components
• It covers a wide range of nucleic acids, from DNA duplexes, triplexes and quadruplexes to RNA

Table of contents

• Cover
• Title Page
• Copyright Page
• About the Editors
• Historical Development and Perspectives of the Series
• Preface to Volume
• Table of Contents
• Contributors to Volume
• Handbooks and Book Series Published and (Co-)edited by the SIGELs
• Chapter 1 Porous Materials Built Up from Metal-Nucleobase Materials
• Chapter 2 Cytosine and Its Derivatives as Useful Tools to Build Unusual and Fascinating Architectures
• Chapter 3 Coordination Polymers with Nucleobase Derivatives: From Electronic Nanodevices to Sensors
• Chapter 4 Heavy Coinage Metal Nucleobase, Nucleoside and (Oligo)Nucleotide Systems: Recent Developments in Self-Assembly, Opto-Electronics and DNA Integration
• Chapter 5 Interplay between Noncovalent Interactions and Metal Ions in Nucleic Acids and Their Constituents
• Chapter 6 Biological Implications of Metal-Nucleobase Complexes
• Chapter 7 Stimuli-Responsive DNA-Binding Metal Complexes
• Chapter 8 How Do Cationic Pt(II) Complexes Modify the Higher-Order Structure of DNA?
• Chapter 9 Metals in Genotyping: From SNPs to Sequencing
• Chapter 10 Nucleic Acids for the Preparation and Control of Continuous Hybrid Metallic Assemblies
• Chapter 11 Recent Advances in the Development of Metal-Responsive Functional DNAs Based on Metal-Mediated Artificial Base Pairing
• Chapter 12 Nucleic Acid-Templated Metal Nanoclusters
• Chapter 13 G-Quadruplex Nucleic Acids and the Role of Metal Ions: Insights from Quantum Chemical Bonding Analyses
• Chapter 14 Transition Metal-Binding G-Quadruplex DNA
• Chapter 15 Metabolite Regulation by Riboswitches: The Role of Metal Ions in Folding, Ligand Binding and Functionality
• Index