Autophagy Dysfunction in Alzheimer's Disease and Dementia

Tadanori Hamano, Tatsuro Mutoh

• Publisher: Academic Press
• Year: 2022
• Print ISBN:
  9780323899062
• eBook ISBN:
  9780323899147
• Topic: Biological Sciences
• Subtopic: Neuroscience
• Index: Biological Sciences

Autophagy Dysfunction in Alzheimer's Disease and Dementia provides an overview for researchers and clinicians on the mechanisms involved in protein degradation in Alzheimer's. The book discusses the implication of autophagy dysfunction in these diseases and how it causes degenerated proteins, including aggregated tau and aggregated amyloid protein. Other sections explores the possibilities of potential drug development through autophagy modulation, making this a great resource on the study of how autophagy dysfunction has been linked to the accumulation of misfolded proteins that cause death of neurons in Alzheimer's and other neurodegenerative diseases. - Discusses the implication of autophagy dysfunction in neurodegenerative diseases - Highlights the mechanisms involved in protein degradation - Explores the possibilities of drug development through autophagy modulation

Table of contents

• Autophagy Dysfunction in Alzheimer's Disease and Dementia
• Chapter 1 Degradation mechanisms of cells
• Chapter 2 Lysosomes-neuronal degeneration in lysosomal storage disorders
• Chapter 3 The autophagy pathway and its key regulators
• Chapter 4 Basics of amyloid β-protein in Alzheimer’s disease
• Chapter 5 Molecular linkages among Aβ, tau, impaired mitophagy, and mitochondrial dysfunction in Alzheimer’s disease
• Chapter 6 Endocytosis in β-amyloid biology and Alzheimer’s disease
• Chapter 7 Autophagy and tau protein
• Chapter 8 BAG3 promotes tau clearance by regulating autophagy and other vacuolar-dependent degradative processes
• Chapter 9 Tau propagation and autophagy
• Chapter 10 Granulovacuolar degeneration in neurodegeneration
• Chapter 11 Autophagy dysfunction in skeletal myopathies: Inclusion body myositis and Danon disease
• Chapter 12 Autophagy in Lewy body diseases and multiple system atrophy
• Chapter 13 Autophagy and Huntington’s disease
• Chapter 14 Drug discovery in Alzheimer’s disease by regulating autophagy
• Chapter 15 Drug discovery in Alzheimer’s disease using metal chelators: Warning toward their usage
• Chapter 16 Development of autophagy enhancers for Parkinson’s disease therapy
• Index