Epigenetics in Organ Specific Disorders
eBook - ePub

Epigenetics in Organ Specific Disorders

,
  1. 666 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

Epigenetics in Organ Specific Disorders

,

About this book

**Selected for Doody's Core TitlesĀ® 2024 in Clinical Genetics**Epigenetics in Organ Specific Disorders, a new volume in the Translational Epigenetics series, provides a foundational overview and nuanced analysis of epigenetic gene regulation distinct to each organ type and organ specific disorders, fully elucidating the epigenetics pathways that promote and regulate disease. After a brief introduction, chapter authors compare epigenetic regulations across normal and disease conditions in different organ tissues, exploring similarities and contrasts. The role of epigenetic mechanisms in stem cells, cell-matrix interactions and cell proliferation, cell migration, cellular apoptosis, necrosis, pyknosis, tumor suppression, and immune responses across different organ types are examined in-depth.Organ specific epigenetic mechanisms and biomarkers of early use in developing drugs, which can selectively target the organ of interest, are also explored to enable new precision therapies. - Identifies unique epigenetic mechanisms that occur in normal and disease conditions in each organ, examining differences and similarities - Explores organ specific epigenetic mechanisms to enable drug discovery and development - Features chapter contributions from leading researchers in the field

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Information

Publisher
Academic Press
Year
2022
Print ISBN
9780128239315
eBook ISBN
9780128239322
Topic
Medicine
Subtopic
Genetics in Medicine

Table of contents

  1. Epigenetics in Organ Specific Disorders
  2. Chapter 1 Introductionā€”Epigenetic regulations in organ specific disorders
  3. Chapter 2 Higher-order chromatin structure and gene regulation
  4. Chapter 3 Molecular and structural interactions between epigenetic regulators
  5. Chapter 4 Epigenetic regulation of necrosis and pyknosis
  6. Chapter 5 HDAC inhibition in cancer
  7. Chapter 6 Epigenetic signatures that maintain stemness in pluripotent and mesenchymal stem cells
  8. Chapter 7 Epigenetic modifications and alternative pre-mRNA splicing in cancer
  9. Chapter 8 Epigenetics of T cell-mediated immunological responses
  10. Chapter 9 Epigenetic modifications and regulation in infection
  11. Chapter 10 Epigenetics of aging
  12. Chapter 11 Epigenetic regulation mediated by diets
  13. Chapter 12 Epigenetic regulations in neurological disorders
  14. Chapter 13 Epigenetics of Disorders Affecting the Anterior Segment of Eye
  15. Chapter 14 Epigenetic regulations in fat depots
  16. Chapter 15 Epigenetic changes in periodontal tissues
  17. Chapter 16 Epigenetics of the pathogenic myofibroblast in lung disease
  18. Chapter 17 Epigenetic mechanisms in cardiovascular diseases
  19. Chapter 18 Epigenetics of NAFLD and NASH
  20. Chapter 19 Role of histone modifications in the development of acute kidney injury
  21. Chapter 20 Epigenetic regulation of chronic kidney disease development following prenatal maternal stress
  22. Chapter 21 Epigenetic modifications and regulations in gastrointestinal diseases
  23. Chapter 22 Epigenetics of radiation-induced GI damage: Role of protein modifications
  24. Chapter 23 Epigenetic modulations in age-associated bone disorders
  25. Chapter 24 Epigenetic regulations in inflammatory diseases
  26. Chapter 25 Epigenetic drug discovery: Recent advances through structure-activity relationships and phenotypic profiling studies
  27. Index