Chromatographic Processes

Modeling, Simulation, and Design

Roger-Marc Nicoud

• Publisher: Cambridge University Press
• Year: 2015
• Print ISBN: 9781107082366
• eBook ISBN: 9781316309940
• Topic: Technology & Engineering
• Subtopic: Chemical & Biochemical Engineering
• Index: Technology & Engineering

Addressing all aspects of the design, modeling and simulation of chromatographic processes, this result-oriented primer provides a practical guide to all the necessary approaches, methodologies and tools. Beginning with key definitions and concepts, it builds up from the most simple to the most complex situations, including multicomponent systems, non-uniform velocity profiles, bed instability, particle size distributions, and the influence of complex environments on chromatographic process design. In addition to covering classical approaches, it introduces efficient tools for investigating chromatographic processes, such as the 'Russian-Lego' approach for linear systems, phenomenological models, and specific shortcuts for deriving the key properties of industrial processes. With an emphasis on real-world problems and applications, step-by step modeling design guidelines, and detailed exercises for self-assessment, this is a must-have guide for practitioners and researchers working in chemical, biochemical, food and pharmaceutical engineering.

Table of contents

• Cover
• Half-title
• Series information
• Title page
• Copyright information
• Table of contents
• Preface and acknowledgments
• 1 Our approach to modeling chromatographic processes
• 2 Linear chromatography: the Russian Lego
• 3 Non-linear chromatography: equilibrium theory
• 4 Fluid–solid phase equilibria
• 5 Mass transfer
• 6 Hydrodynamics of chromatographic columns
• 7 Simulating chromatographic columns
• 8 Counter-current systems
• 9 Chromatographic modes and their optimization
• 10 Addressing a few industrial problems
• 11 Conclusion
• Appendix A Some important properties of the Laplace transform
• Appendix B Inlet and outlet boundary conditions
• Appendix C Equilibrium theory: single-solute chromatograms
• Appendix D Equilibrium theory: binary chromatograms
• Appendix E The influence of the porosity determination on chromatographic modeling
• Appendix F Useful physico-chemical data and orders of magnitude
• Appendix G Fick and Maxwell–Stefan approaches to diffusion
• Appendix H Non-linear LDF for multi-solute systems
• Appendix I Situations that make the use of the MC model problematic
• Appendix J Typical industrial chromatographic processes
• Notation
• Index