- 38 pages
- English
- PDF
- Available on iOS & Android
eBook - PDF
Therapeutic Targeting of RAS Mutant Cancers
About this book
The KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS. Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms.
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Information
Table of contents
- Cover
- Title page
- Copyright page
- Therapeutic Targeting of RAS Mutant Cancers
- References
- Acknowledgments
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Yes, you can access Therapeutic Targeting of RAS Mutant Cancers by Edward C. Stites,Kendra Paskvan,Shumei Kato in PDF and/or ePUB format, as well as other popular books in Medicine & Oncology. We have over 1.5 million books available in our catalogue for you to explore.