Molecular Recognition in Pharmacology
eBook - ePub

Molecular Recognition in Pharmacology

  1. 188 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

Molecular Recognition in Pharmacology

About this book

This unique volume traces the behavior of the drug substance, starting from the initial pre-contact stage, and ending with the formation of the complex. Molecular recognition lies in the foundation of every life form and includes many mysteries. Currently, studies on this topic in pharmacology are limited to determining the properties of complexes of medicinal substances (drugs) with specific (complementary) biomolecules: receptors, enzymes, ion channels etc. The results present the mechanisms preventing drugs from such non-specific binding. This direction is very fruitful, although the phenomenon of molecular recognition is far wider.

Features

  • Presents the basics of thermodynamics and kinetics of complex formation between ligands and receptors
  • Selected novel therapeutic concepts are tested and validated
  • Provides a review of the pharmacophore approach and drug design methods
  • By its nature, pharmacology is a multi-disciplinary science, hence, disciplinary areas include chemistry, biology and neuroscience
  • Discusses hot topics including 3D structure determination techniques and in silico methods and neural networks

The main theme of the book is the consideration of mechanisms created by nature to protect physiologically active substances from being stuck on nonspecific acceptors in the body. The book describes the materials that aid in the development of new medicinal substances. It is intended for researchers, as well as upper-level undergraduate and graduate students interested in the problems of molecular pharmacology and drug design.

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Yes, you can access Molecular Recognition in Pharmacology by Mikhail Darkhovskiy in PDF and/or ePUB format, as well as other popular books in Medicine & Biophysics. We have over one million books available in our catalogue for you to explore.

Information

Publisher
CRC Press
Year
2023
Print ISBN
9781032431086
eBook ISBN
9781000999242
Edition
1
Topic
Medicine
Subtopic
Biophysics

Table of contents

  1. Cover
  2. Half-Title Page
  3. Series Page
  4. Title Page
  5. Copyright Page
  6. Table of Contents
  7. Preface
  8. Introduction: Molecular recognition and new drug development: Extracts from conducted studies
  9. 1 Energy of Interactions in Drugā€“Receptor Complex Formation
  10. 2 Methods for Studying Drug-Receptor Binding
  11. 3 Methods for Drug Discovery Research
  12. 4 Thermodynamics of Drugā€“Receptor Complex Formation
  13. 5 Effect of Conformational Entropy on Affinity of Specific Ligands
  14. 6 Kinetics of Drugā€“Receptor Complex Formation
  15. 7 Distant and Contact Interaction of Drugs and Receptors
  16. 8 Bound Water Effects on the Interaction of Chemical Groups
  17. 9 Information Required for Receptor Recognition
  18. 10 Agonists and Antagonists
  19. 11 Nonselective Drugs
  20. 12 Search Paths for Novel Therapeutic Drugs
  21. Index