Neurotoxicology

G. Jean Harry, Hugh A. Tilson

• Publisher: CRC Press
• Year: 2016
• Print ISBN:
  9781420054873
• eBook ISBN:
  9781040172742
• Topic: Medicine
• Subtopic: Toxicology

This new edition presents an integrated approach to neurotoxicology, the study of organisms' responses to changes in their environment and how interruption of the flow of information by chemical exposure causes a wide range of effects – from learning deficits, sensory disturbances in the extremities, and muscle weakness to seizures and signs similar to neurodegenerative disorders such as Parkinson's or Alzheimer's disease. It is an essential resource for understanding the sites and mechanisms of neurotoxicity, for formulating testable hypotheses about the effects of neurotoxicants, and for improving the risk assessment process.

Table of contents

• Cover
• Half Title
• Series Page
• Title Page
• Copyright Page
• Preface
• Table of Contents
• Contributors
• 1 Molecular Approaches to Identify Specific Modes of Action for Neurotoxicity In Vitro Ram Ramabhadran and Steven O. Simmons Genetic and Cellular Toxicology Branch, Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, U.S.A. William R. Mundy Systems Biology Branch, Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, U.S.A.
• 2 Bioinformatic and Computational Approaches for Analysis of Genomics Data in Neurotoxicology Research Julia M. Gohlke Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, U.S.A. Willard M. Freeman and Kent E. Vrana Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania, U.S.A.
• 3 Neurotoxicology of Barriers in the Developing Brain Norman R. Saunders, Mark D. Habgood, and Katarzyna M. Dziegielewska Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia
• 4 Thyroid Hormones—Impact on the Developing Brain: Possible Mechanisms of Neurotoxicity Mary E. Gilbert Neurotoxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, and Department of Psychology, University of North Carolina, Chapel Hill, North Carolina, U.S.A. R. T. Zoeller Department of Biology, University of Massachusetts, Amherst, Massachusetts, U.S.A.
• 5 Dopaminergic Nerves as Targets for Neurotoxins Richard M. Kostrzewa Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, U.S.A. Lucyna Antkiewicz-Michaluk Department of Neurochemistry, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland Francisco Fornai Department of Human Morphology and Applied Biology, University of Pisa, Pisa, and Laboratory of Neurobiology of Movement Disorders Irccs, Inm Neuromed Pozzilli, Isernia, Italy
• 6 Endocrine Disruption and Senescence: Consequences for Reproductive Endocrine and Neuroendocrine Systems, Behavioral Responses, and Immune Function Mary Ann Ottinger, Emma T. Lavoie, Karen Dean, and Brandon D. Sitzmann Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, U.S.A. Michael J. Quinn, Jr. U.S. Army Center for Health Promotion and Preventive Medicine, Directorate of Toxicology, Health Effects Research Program, Aberdeen Proving Ground, Maryland, U.S.A.
• 7 White Fat Tissue, Obesity, and Possible Role in Neurodegeneration Palaniyandi Ravanan* and Rana Awada Laboratoire de Biochimie et Génétique Moléculaire, Groupe d’Etude sur l’Inflammation Chronique et l’Obésité (Geico), Faculté des Sciences, Université de La Réunion, France G. Jean Harry Neurotoxicology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, U.S.A. Christian Lefebvre d’Hellencourt Laboratoire de Biochimie et Génétique Moléculaire, Groupe d’Etude sur l’Inflammation Chronique et l’Obésité (Geico), Faculté des Sciences, Université de La Réunion, France
• 8 Microglia: Neuroprotective and Neurodestructive Properties G. Jean Harry Neurotoxicology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, U.S.A.
• 9 The Slice Culture Model: Considerations for Neurotoxicity Assessment Andrew D. Kraft Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, U.S.A.
• 10 Design-Based Stereology and Video Densitometry for Assessment of Neurotoxicological Damage Peter R. Mouton Byrd Alzheimer Center and Research Institute, University of South Florida College of Medicine, Tampa, Florida, and Stereology Resource Centers, Chester, Maryland, U.S.A. Marcia N. Gordon Byrd Alzheimer Institute and Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, University of South Florida College of Medicine, Tampa, Florida, U.S.A.
• 11 Effect of Neurotoxins on Brain Tissue and Function Revealed Through In Vivo Mr Imaging and Spectroscopy Margaret J. Rosenbloom Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, and Neuroscience Program, Sri International, Menlo Park, California, U.S.A. Edith V. Sullivan Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, U.S.A. Adolf Pfefferbaum Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, and Neuroscience Program, Sri International, Menlo Park, California, U.S.A.
• 12 Principles of Behavioral Phenotyping of Neonatal and Adult Mice Susan H. Brunssen Division of Family Health, School of Nursing, and Neurodevelopmental Disorders Research Center, University of North Carolina, Chapel Hill, North Carolina, U.S.A. Sheryl S. Moy Neurodevelopmental Disorders Research Center and Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, U.S.A. Grace E. Kissling National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, U.S.A.
• Index