The Regulatory Genome in Adaptation, Evolution, Development, and Disease
eBook - ePub

The Regulatory Genome in Adaptation, Evolution, Development, and Disease

  1. 418 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

The Regulatory Genome in Adaptation, Evolution, Development, and Disease

About this book

The Regulatory Genome in Adaptation, Evolution, Development, and Disease synthesizes insights from recent genomic and gene expression studies across organisms, from humans to plants, animals, and single cell life, exploring common roles gene regulation plays in adaptive evolution, developmental biology and susceptibility to disease. The book sheds light on gene regulation across evolutionary timelines, illuminating new areas of focus and future research. Chapters consider key elements in gene expression regulation, fundamentals of genomic alterations over time, and in response to environmental and local conditions, epigenetics in adaptive evolution, and adaptive gene regulation in healthy processes and developmental biology, and in disease biology. Throughout the book, a comparative approach is adopted across organisms to highlight common evolutionary themes and genome diversity revealed by recent sequencing and GWAS studies, as well as how this informs our understanding of human adaptive evolution. The book finishes by detailing how we can use this knowledge to impact disease outcomes and healthy human metabolism, development, and physiology. - Reviews key elements in the regulation of gene expression and modes of studying gene regulation across evolutionary timelines - Adopts a cross-species view, synthesizing recent sequencing and GWAS studies across organisms to draw out fresh meaning and highlight pathways for future research - Considers altered gene expression associated with developmental defects and disease, as well as healthy biology and physiology, and our adaptive response to disease influence

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Yes, you can access The Regulatory Genome in Adaptation, Evolution, Development, and Disease by Moyra Smith in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Genetics & Genomics. We have over one million books available in our catalogue for you to explore.

Table of contents

  1. Cover
  2. Front Matter
  3. Table of Contents
  4. Copyright
  5. Dedication
  6. Preface
  7. Acknowledgments
  8. Epigraph
  9. List of Illustrations
  10. List of Tables
  11. Chapter 1 : Gene regulation in physiological processes
  12. Chapter 2 : Epigenetics, the nonprotein coding genome, and human accelerated sequences
  13. Chapter 3 : Gene expression and regulation relative to specific tissues and functions
  14. Chapter 4 : Evo-Devo and morphological diversity
  15. Chapter 5 : Adaptation and evolution
  16. Chapter 6 : Adaptations metabolic and genomic to environmental changes
  17. Chapter 7 : Regulatory elements relevant to brain, connectome, and neurodevelopmental disorders
  18. Chapter 8 : Altered gene expression associated with developmental defects and disease
  19. Chapter 9 : Metabolic, epigenetic functions and correlations with phenotype
  20. Chapter 10 : Aging, genomic mitochondrial, and regulatory changes
  21. Chapter 11 : The regulatory genome and defects in monogenic diseases
  22. Chapter 12 : Epigenetics and human disease
  23. Chapter 13 : Connecting developmental defects and evolutionary findings
  24. Chapter 14 : The regulatory genome and complex common diseases
  25. Index
  26. A