Transcription and Translation in Health and Disease provides a detailed overview of the regulators underlying transcription and translation in relation to a variety of human diseases and disorders. Beginning with an introduction into the current perspectives relating to these processes in human disease, the book expands to focus on specific mechanisms underlying conditions such as arthritis, cancer, neurological disorders, diabetes and cardiovascular disease. This book considers RNA processing and related mechanisms in eukaryotes including RNA splicing, RNA binding proteins, RNA interference, microRNAs, RNA editing, transcription factors, RNAi screening, CRISPR activation, CRISPR-Cas9 interference, and post-translational modifications. It provides a structured and detailed overview of the various regulators underlying molecular processes and their impact on health and disease, equipping readers with the necessary knowledge for further investigation in the areas of treatment and therapeutic intervention. - Discusses the role played by transcription and translational regulation in various diseases, including cancer, diabetes, cardiovascular disease and neurological disease - Considers a range of post-transcriptional regulators, including RNA-binding proteins, non-coding RNAs, epigenetic modifiers, alternative splicing and telomerase-binding proteins - Covers the topic from fundamental knowledge to the latest developments in clinical application - Includes a section dedicated to therapeutic applications

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Yes, you can access Transcription and Translation in Health and Disease by Manoj Garg, Gautam Sethi, Amit Kumar Pandey, Manoj Garg,Gautam Sethi,Amit Kumar Pandey in PDF and/or ePUB format, as well as other popular books in Sciences biologiques & Biologie moléculaire. We have over one million books available in our catalogue for you to explore.

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Cover
Front Matter
Table of Contents
Copyright
Contributors
About the editors
Preface
List of Illustrations
List of Tables
Chapter 1 : Current perspective of transcriptional regulators in human health and diseases
Chapter 2 : Role of alternative splicing in health and diseases
Chapter 3 : Role of transcriptional and posttranscriptional regulation of sphingolipid genes in molecular heterogeneity of breast cancer
Chapter 4 : Who dictates and when: Genetic and epigenetic dictatorships in breast cancer response and resistance to therapy
Chapter 5 : Cross-talk between NF-κB and telomerase in cancer: Implications in therapy
Chapter 6 : Genome editing and regulation of transcription and translational using CRISPR-Cas9 system
Chapter 7 : Regulation of posttranscriptional events by RNA-binding proteins
Chapter 8 : The language of posttranslational modifications and deciphering it from proteomics data
Chapter 9 : Noncoding RNAs in human health and diseases
Chapter 10 : MiRNAs as epigenetic regulators for gut microbiome
Chapter 11 : Crosstalk between microRNAs and epigenetics during brain development and neurological diseases
Chapter 12 : Implications of miRNA in autoimmune and inflammatory skin diseases
Chapter 13 : Micro-RNA contribution to angiogenesis in cancer
Chapter 14 : Emerging role of mRNA and RNA binding proteins in Diabetes
Chapter 15 : Caenorhabditis elegans: An interesting host for aging-related studies
Chapter 16 : The role of LncRNA and micro-RNA targeting GLI transcription factors in human cancers
Chapter 17 : Inhibitors targeting epigenetic modifications in cancer
Chapter 18 : Modulation of epigenetic methylation enzymes by synthetic and natural agents
Chapter 19 : Transcriptional regulatory network associated with multiple sclerosis pathogenesis
Chapter 20 : Role of adipokines in the pathophysiology of coronary artery disease
Index
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About this book

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Table of contents