Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS-CoV2 Infection

Revolutionary Strategies to Combat Pandemics

Arpana Parihar, Raju Khan, Ashok Kumar, Ajeet Kumar Kaushik, Hardik Gohel, Hardik A. Gohel

• Publisher: Academic Press
• Year: 2022
• Print ISBN:
  9780323911726
• eBook ISBN:
  9780323998000
• Topic: Medicine
• Subtopic: Pharmacology

Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS-CoV2 Infection: Revolutionary Strategies to Combat Pandemics compiles information about various computational bioinformatic approaches that can help combat viral infection. The book includes working knowledge of various molecular docking and molecular dynamic simulation approaches that have been exploited for drug repurposing and drug designing purpose. In addition, it sheds light on reverse vaccinomics and immunoinformatic approaches for vaccine designing against SARS-CoV2 infection. This book is an essential resource for researchers, bioinformaticians, computational biologists, computational chemists and pharmaceutical companies who are working on the development of effective and specific therapeutic interventions and point-of-care diagnostic devices using various computational approaches. - Covers computational based approaches for designing and repurposing drugs - Discusses immunoinformatic and reverse vaccinomic approaches for effective vaccine design - Categorizes information about artificial intelligence-based drug screening and diagnostic tools

Table of contents

• Cover
• Title page
• Table of Contents
• Copyright
• Contents
• List of contributors
• Preface
• Acknowledgments
• List of Illustrations
• List of Tables
• Chapter 1 : Overview of coronavirus pandemic
• Chapter 2 : Epidemiology, transmission and pathogenesis of SARS-CoV-2
• Chapter 3 : The global impact of pandemics on world economy and public health response
• Chapter 4 : Genomic, proteomic and metabolomic profiling of severe acute respiratory syndrome-Coronavirus-2
• Chapter 5 : Currently available drugs for the treatment of Coronavirus-2
• Chapter 6 : Holistic strategies to mitigate the economic, societal, and health burden of the Coronavirus disease-2019 pandemic
• Chapter 7 : Natural products as a therapy to combat against SARS-CoV-2 virus infection
• Chapter 8 : Advanced high-throughput biosensor-based diagnostic approaches for detection of severe acute respiratory syndrome-coronavirus-2
• Chapter 9 : Pharmacophore mapping and modeling approaches for drug development
• Chapter 10 : Quantitative structure–activity relationship-based computational approaches
• Chapter 11 : Molecular docking and molecular dynamic simulation approaches for drug development and repurposing of drugs for severe acute respiratory syndrome-Coronavirus-2
• Chapter 12 : Computational approaches for drug repositioning and repurposing to combat SARS-CoV-2 infection
• Chapter 13 : System and network biology-based computational approaches for drug repositioning
• Chapter 14 : Databases, DrugBank, and virtual screening platforms for therapeutic development
• Chapter 15 : Absorption, distribution, metabolism, excretion, and toxicity assessment of drugs using computational tools
• Chapter 16 : Immunoinformatics and reverse vaccinomic approaches for effective design
• Chapter 17 : Artificial intelligence-based drug screening and drug repositioning tools and their application in the present scenario
• Chapter 18 : Machine Learning and Deep Learning based AI Tools for Development of Diagnostic Tools
• Chapter 19 : Present therapeutic and diagnostic approaches for SARS-CoV-2 infection
• Chapter 20 : Clinically available/under trial drugs and vaccines for treatment of SARS-COV-2
• Chapter 21 : Present and future challenges in therapeutic designing using computational approaches
• Chapter 22 : Digital healthcare data management using blockchain technology in genomics and COVID-19
• Chapter 23 : Prediction of drug–target interaction —a helping hand in drug repurposing
• Chapter 24 : Artificial intelligence methods to repurpose and discover new drugs to fight the Coronavirus disease-2019 pandemic
• Chapter 25 : Severe acute respiratory syndrome coronavirus-2: An era of struggle and discovery leading to the emergency use authorization of treatment and prevention measures based on computational analysis
• Index
• A