Privileged Scaffolds in Drug Discovery

Bin Yu, Ning Li, Caiyun Fu

• Publisher: Academic Press
• Year: 2023
• Print ISBN: 9780443186110
• eBook ISBN: 9780443186127
• Topic: Medicine
• Subtopic: Pharmacology

Privileged Scaffolds in Drug Discovery is the most complete and up-to-date work in the area. Covering a wide range of privileged structures, it is a perfect reference for scientists involved in targeted drug development. The editors recruited epserts from several prestigious Chinese institutions to cover the areas of antiviral drugs, chalcone, pyrimidine, (benz)imidazoles, natural product-derived privileged scaffolds, N-Sulfonyl carboxamides, kinase inhibitors, antitumor molecules, antineurodegenerative drugs, triazoles, oxazolidinone, indole and indoline scaffolds, tigliane diterpenoids, peptide and peptide-based drugs, quassinoids, and others including pseudonatural products, macrocycles, stable peptides and peptidomimetics. The book also explores scaffolds in drug molecules approved in recent years. Privileged Scaffolds in Drug Discovery is a complete reference for researchers in drug discovery and organic synthesis, in academic and corporate settings, who are investigating privileged structures upon which to base new drugs. Researchers in medicinal chemistry and chemical biology will also find the contents of this book valuable. - Provides wide coverage of privileged scaffolds in new drug discovery - Includes complex and diverse natural product scaffolds - Covers applications to peptides and peptide-based drugs

Table of contents

• Title of Book
• Cover image
• Title page
• Table of Contents
• Copyright
• List of contributors
• Preface
• Introduction
• Chapter 1 Thiazole, a privileged scaffold in drug discovery
• Chapter 2 Chalcones: Diverse biological activities and structure–activity relationships
• Chapter 3 Privileged chalcone scaffolds in drug discovery
• Chapter 4 The N-sulfonyl carboxamide moiety as a privileged structure in approved drugs
• Chapter 5 Scaffolds in cytotoxic drugs and novel antitumor molecules interacting with nucleic acids
• Chapter 6 Triazoles: a privileged scaffold in drug design and novel drug discovery
• Chapter 7 Oxazolidinone scaffolds in drug discovery and development
• Chapter 8 Indole and indoline scaffolds in drug discovery
• Chapter 9 Cyanopyridine as a privileged scaffold in drug discovery
• Chapter 10 Indazole as a privileged scaffold in drug discovery
• Chapter 11 (Benz)imidazoles: privileged scaffolds in medicinal chemistry
• Chapter 12 Tranylcypromine (TCP): a privileged scaffold for designing histone lysine demethylase 1 inhibitors
• Chapter 13 Applications of piperazine scaffold in drug design
• Chapter 14 Thiols as a privileged scaffold against metallo-β-lactamases
• Chapter 15 Tetrahydro-β-carboline scaffold in drug discovery
• Chapter 16 Benzoxaborole: a privileged scaffold for drug discovery
• Chapter 17 Privileged scaffolds in anti-diabetic drug discovery
• Chapter 18 Authentic HIV-1 integrase inhibitors for the treatment of HIV-1/AIDS
• Chapter 19 2-Aminopyrimidine: a privileged scaffold in kinase drug discovery
• Chapter 20 Alzheimer's disease therapeutics: current strategies and future directions
• Chapter 21 Sulfonyl fluorides as warheads in drug discovery
• Chapter 22 α,β-Bifunctionalized carbonyl compounds as privileged motifs in drug discovery and their synthetic protocols
• Chapter 23 Diarylpyrimidines and related analogs as antiviral agents
• Chapter 24 Organic synthetic methodology-based new scaffolds in drug discovery
• Chapter 25 Natural resource of anti–human immunodeficiency virus leading compounds: tigliane diterpenoids
• Chapter 26 Biological phenethyl glycosides from plants
• Chapter 27 Triterpenoids and saponins in drug discovery
• Chapter 28 Casbene-derived diterpenoids
• Chapter 29 Quassinoids: phytochemistry and antitumor prospect
• Chapter 30 Structural diversity, biosynthesis, and biological functions of meroterpenoids from microbial metabolites
• Chapter 31 Glucocorticoid compounds in drug discovery by targeting glucocorticoid receptor protein
• Chapter 32 Peptide and peptide-based drugs
• Chapter 33 Stapled peptides for new drug discovery
• Chapter 34 Current status and trends in research and development of polypeptide drugs
• Chapter 35 Unique opportunities of metal scaffolds in drug design
• Chapter 36 N-Heterocyclic carbene as privileged scaffold in medicinal inorganic chemistry
• Chapter 37 Selenium-containing heterocycles
• Chapter 38 Computational methods for scaffold hopping
• Index