Physico-Chemical Aspects of Drug Action
eBook - PDF

Physico-Chemical Aspects of Drug Action

Proceedings of the Third International Pharmacological Meeting

  1. 397 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Physico-Chemical Aspects of Drug Action

Proceedings of the Third International Pharmacological Meeting

About this book

Physico-Chemical Aspects of Drug Action, Volume 7 covers topics on drug kinetics and the overall physicochemical properties of the drug in relation therewith, and the physicochemical aspects of the drug-receptor interaction, putting emphasis on receptor mechanisms and specific properties required for certain types of drugs in this respect. The book starts with some contributions dealing with various general aspects of drug kinetics followed by some contributions dealing with the relationship between certain physicochemical properties of drug molecules and their action. The text describes the pharmacokinetics and dose-concentration relationships; the time course of the biological response to drugs; and the empirical equations for correlating biological efficiency of organic compounds. The text also describes molecular basis for the action of chemotherapeutic drugs; the structure-activity studies on sulphonamides; and the water extrusion hypothesis. The mathematical treatment of two-point attachment between drug and receptor; the molecular properties and biological activity of catecholamines and certain related compounds; and the structure-activity relationships of diarylcarbinolethers are also considered. The book further tackles quantum mechanically-derived electronic distributions in the conformers of 2-pam; and the molecular basis for the action of certain drugs in the central nervous system. Pharmacologists and chemists will find the book invaluable.

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Information

Publisher
Pergamon
Year
2017
Print ISBN
9780080032658
eBook ISBN
9781483152691
Topic
Medicine
Subtopic
Pharmacology

Table of contents

  1. Front Cover
  2. Physico-Chemical Aspects of Drug Action
  3. Copyright Page
  4. Table of Contents
  5. LIST OF AUTHORS AND PARTICIPANTS
  6. CHAPTER 1. INTRODUCTORY REMARKS
  7. CHAPTER 2. PHARMACOKINETICS AS A BASIC MEDICAL PROBLEM
  8. CHAPTER 3. KINETICS AND IMPLICATIONS OF DISSOLUTION RATE. LIMITED GASTROINTESTINAL ABSORPTION OF DRUGS
  9. CHAPTER 4. PHARMACOKINETICS AND DOSE-CONCENTRATION RELATIONSHIPS
  10. CHAPTER 5. THE TIME COURSE OF THE BIOLOGICAL RESPONSE TO DRUGS :A MATHEMATICAL TREATMENT
  11. CHAPTER 6. MPIRICAL EQUATIONS FOR CORRELATING BIOLOGICAL EFFICIENCY OF ORGANIC COMPOUNDS
  12. CHAPTER 7. THE USE OF SUBSTITUENT CONSTANTS IN STRUCTURE-ACTIVITY STUDIES
  13. CHAPTER 8. MOLECULAR BASIS FOR THE ACTIO N OF CHEMOTHERAPEUTIC DRUG STRUCTURE-ACTIVITY STUDIES ON SULFONAMIDES
  14. CHAPTER 9. THE STUDY OF DRUG BINDING SITES BY NUCLEAR MAGNETIC RELAXATION
  15. CHAPTER 10. PATTERNS OF LIGAND-INDUCED CHANGES ON A RECEPTOR SURFACE : THE WATE EXTRUSION HYPOTHESIS
  16. CAPTER 11. BIOLOGICAL DRUG PARAMETERS FOR STUDIES OF THE RELATIONSHIP BETWEEN STRUCTURE AND ACTIVITY.
  17. CHAPTER 12. MATHEMATICAL TREATMENT OF TWO - POINT ATTACHMENT BETWEEN DRUG AND RECEPTOR
  18. CHAPTER 13. CHEMICAL STRUCTURE AND BIOLOGICAL ACTIVITY. SOME GENERAL PRINCIPLES
  19. CHAPTER 14. MOLECULAR PROPERTIES AND BIOLOGICAL ACTIVITY OF CATECHOLAMINES AND CERTAIN RELATED COMPOUNDS
  20. CHAPTER 15. SOMEEL ECTRONIC ASPECTS OF PHARMACOLOGY
  21. CHAPTER 16. DIARYLCARBINOL ETHERS: STRUCTURE ACTIVITY RELATIONSHIPS. A PHYSICO- CHEMICAL APPROACH
  22. CHAPTER 17. QUANTUM MECHANICALLY DERIVED ELECTRONIC DISTRIBUTIONS IN THE CONFORMERS OF 2-PAM
  23. CHAPTER 18. A MOLECULAR BASIS FOR THE ACTION OF CERTAIN DRUGS IN THE CENTRAL NERVOUS SYSTEM1
  24. INDEX

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Yes, you can access Physico-Chemical Aspects of Drug Action by E. J. Ariëns in PDF and/or ePUB format, as well as other popular books in Medicine & Pharmacology. We have over 1.5 million books available in our catalogue for you to explore.